European Radiology

, Volume 14, Issue 4, pp 686–690

Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

Authors

    • Department of RadiologyUniversity of Cologne
  • Bettina Sorger
    • Department of RadiologyUniversity of Cologne
  • Ralf Girnus
    • Department of RadiologyUniversity of Cologne
  • Kathrin Lasek
    • Department of RadiologyUniversity of Cologne
  • Mohammad Maarouf
    • Department of Stereotaxy and Functional NeurosurgeryUniversity of Cologne
  • Christoph Wedekind
    • Department of NeurosurgeryUniversity of Cologne
  • Jürgen Bunke
    • Philips Medical Systems
  • Oliver Schulte
    • Department of RadiologyUniversity of Cologne
  • Barbara Krug
    • Department of RadiologyUniversity of Cologne
  • Klaus Lackner
    • Department of RadiologyUniversity of Cologne
  • Volker Sturm
    • Department of Stereotaxy and Functional NeurosurgeryUniversity of Cologne
Neuro

DOI: 10.1007/s00330-003-2051-0

Cite this article as:
Hesselmann, V., Sorger, B., Girnus, R. et al. Eur Radiol (2004) 14: 686. doi:10.1007/s00330-003-2051-0

Abstract

This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.

Keywords

Parkinson's diseasefMRIStereotaxic techniquesElectric stimulation therapy

Copyright information

© Springer-Verlag 2004