European Radiology

, Volume 14, Issue 4, pp 686–690

Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

  • Volker Hesselmann
  • Bettina Sorger
  • Ralf Girnus
  • Kathrin Lasek
  • Mohammad Maarouf
  • Christoph Wedekind
  • Jürgen Bunke
  • Oliver Schulte
  • Barbara Krug
  • Klaus Lackner
  • Volker Sturm
Neuro

DOI: 10.1007/s00330-003-2051-0

Cite this article as:
Hesselmann, V., Sorger, B., Girnus, R. et al. Eur Radiol (2004) 14: 686. doi:10.1007/s00330-003-2051-0

Abstract

This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.

Keywords

Parkinson's diseasefMRIStereotaxic techniquesElectric stimulation therapy

Copyright information

© Springer-Verlag 2004

Authors and Affiliations

  • Volker Hesselmann
    • 1
  • Bettina Sorger
    • 1
  • Ralf Girnus
    • 1
  • Kathrin Lasek
    • 1
  • Mohammad Maarouf
    • 2
  • Christoph Wedekind
    • 3
  • Jürgen Bunke
    • 4
  • Oliver Schulte
    • 1
  • Barbara Krug
    • 1
  • Klaus Lackner
    • 1
  • Volker Sturm
    • 2
  1. 1.Department of RadiologyUniversity of CologneCologneGermany
  2. 2.Department of Stereotaxy and Functional NeurosurgeryUniversity of CologneCologneGermany
  3. 3.Department of NeurosurgeryUniversity of CologneCologneGermany
  4. 4.Philips Medical SystemsHamburgGermany