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Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

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Abstract

This article deals with technical aspects of intraoperative functional magnetic resonance imaging (fMRI) for monitoring the effect of deep brain stimulation (DBS) in a patient with Parkinson's disease. Under motor activation, therapeutic high-frequency stimulation of the subthalamic nucleus was accompanied by an activation decrease in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum. Furthermore, an activation increase in the contralateral basal ganglia and insula region were detected. These findings demonstrate that fMRI constitutes a promising clinical application for investigating brain activity changes induced by DBS.

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Acknowledgement

The work was supported by the Koeln Fortune Program/Faculty of Medicine, University of Cologne.

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Authors and Affiliations

  1. Department of Radiology, University of Cologne, Joseph-Stelzmann-Strasse 9, 50924, Cologne, Germany

    Volker Hesselmann, Bettina Sorger, Ralf Girnus, Kathrin Lasek, Oliver Schulte, Barbara Krug & Klaus Lackner

  2. Department of Stereotaxy and Functional Neurosurgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50924, Cologne, Germany

    Mohammad Maarouf & Volker Sturm

  3. Department of Neurosurgery, University of Cologne, Joseph-Stelzmann-Strasse 9, 50924, Cologne, Germany

    Christoph Wedekind

  4. Philips Medical Systems, Hamburg, Germany

    Jürgen Bunke

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  1. Volker Hesselmann
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  2. Bettina Sorger
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  3. Ralf Girnus
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  4. Kathrin Lasek
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  5. Mohammad Maarouf
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  8. Oliver Schulte
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  9. Barbara Krug
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  11. Volker Sturm
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Correspondence to Volker Hesselmann.

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Hesselmann, V., Sorger, B., Girnus, R. et al. Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease. Eur Radiol 14, 686–690 (2004). https://doi.org/10.1007/s00330-003-2051-0

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  • DOI: https://doi.org/10.1007/s00330-003-2051-0

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