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Evidence-based Guidelines for Perioperative Management of Diabetes in Cardiac and Vascular Surgery

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Abstract

Background

Management of patients with hyperglycaemia undergoing vascular and cardiac surgery is important, with mounting evidence that hyperglycaemia in this setting is associated with worse outcomes. Evidence-based guidelines for the management of these patients have been limited.

Methods/Results

Our institution was aware of the lack of standardization of care in this growing population group and formed a multidisciplinary guideline development group to develop evidence-based guidelines to standardize the perioperative management of hyperglycaemia.

Conclusion

This series of articles outlines the process of developing evidence-based guidelines and the recommendations for perioperative management of patients with hyperglycaemia and diabetes undergoing cardiac and vascular surgery at our institution.

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Abbreviations

ADA:

American Diabetes Association

BSL:

Blood sugar level

CABG:

Coronary artery bypass grafting

CVVHDF:

Continuous veno-venous haemodialysis and filtration

CII:

Continuous insulin infusion

DNE:

Diabetes Nurse Educator

FBG:

Fasting blood glucose

eGFR:

Estimated glomerular filtration rate

GDG:

Guideline Development Group

GIK:

Potassium, Insulin and glucose infusion

HbA1c:

Glycosylated haemoglobin

ICU:

Intensive care unit

IFG:

Impaired fasting glucose

IGT:

Impaired glucose tolerance

NHMRC:

National Health and Medical Research Council

OGTT:

Oral glucose tolerance test

RBG:

Random blood glucose

TPN:

Total parenteral nutrition

WHO:

World Health Organisation

References

  1. World Health Organization (WHO) (2006) Global strategy on Diet, Physical Activity and Health. Diabetes. http://www.who.int/dietphysicalactivity/publications/facts/diabetes/en/. Accessed September 19, 2006

  2. Dunstan DW, Zimmet PZ, Welborn T, on behalf of the AusDiab Steering Committee et al (2001) Diabesity and associated disorders in Australia-2000. The accelerating epidemic. The Australian Diabetes, Obesity and Lifestyle Study (AusDiab). International Diabetes Institute, Melbourne

    Google Scholar 

  3. Latham R, Lancaster A, Covington J et al (2001) The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol 22(10):607–612

    Article  PubMed  CAS  Google Scholar 

  4. Lauruchskat AH (2005) Prevalence and risks of undiagnosed diabetes mellitus in patients undergoing CABG. Circulation 112(16):2397–2402

    Article  Google Scholar 

  5. Swenne CL, Lindholm C, Borowiec J et al (2005) Peri-operative glucose control and development of surgical wound infections in patients undergoing coronary artery bypass graft. J Hosp Infect 61:201–212

    Article  PubMed  CAS  Google Scholar 

  6. Dunstan DW, Zimmet PZ, Welborn TA et al (2002) The rising prevalence of diabetes and impaired glucose tolerance: the Australian Diabetes, Obesity and Lifestyle Study. Diabetes Care 25:829–834

    Article  PubMed  Google Scholar 

  7. Consortium DAGD (2005) National evidence based guidelines for the management of type 2 diabetes, 2nd edn. National Health and Medical Research Council, Canberra

  8. (1998) Standards of medical care for patients with diabetes mellitus. Diabetes Care 21(Suppl 1):23S–31S

  9. Ten facts about Diabetes. http://www.mydr.com.au/default_new.asp?article=2885. Accessed September 19, 2006

  10. Uusitupa MI, Niskanen LK, Sitonen O et al (1993) Ten year cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in Type 2 (non insulin-dependent) diabetic and non-diabetic subjects. Diabetologia 36(11):1175–1184

    Article  PubMed  CAS  Google Scholar 

  11. Hypertension in Diabetes Study Group (1995) Prevalence of hypertension in newly presenting Type 2 diabetic patients and the association of risk factors for cardiovascular and diabetic complications. J Hypertension 11:309–317

    Google Scholar 

  12. Kadoi Y, Saito S, Fujita N et al (2005) Risk factors for cognitive dysfunction after coronary artery bypass graft surgery in patients with type 2 diabetes. J Thorac Cardiovasc Surg 129(3):576–583

    Article  PubMed  Google Scholar 

  13. NBPA Committee (2004) Hypertension Management Guide for Doctors, 2004 Guideline. Heart Foundation, Sydney

    Google Scholar 

  14. Guvener M, Pasaoglu I, Demircin M et al (2002) Perioperative hyperglycaemia is a strong correlate of postoperative infection in type II diabetic patients after coronary artery bypass grafting. Endocr J 49(5):531–537

    Article  PubMed  Google Scholar 

  15. Trick WE, Scheckler WE, Tokars JI et al (2000) Modifiable risk factors associated with deep sternal site infection after coronary artery bypass grafting. J Thorac Cardiovasc Surg 119(1):108–114

    Article  PubMed  CAS  Google Scholar 

  16. Cohen O, Dankner R, Chetrit A et al (2003) Multidisciplinary intervention for control of diabetes in patients undergoing coronary artery bypass graft (CABG). Cardiovasc Surg 11(3):195–200

    Article  PubMed  Google Scholar 

  17. Salpeter SR, Greyber E, Pasternak GA et al. (2006) Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Library, CD002967

  18. DAGD Consortium (2009) National evidence based guidelines for blood glucose control in type 2 diabetes. National Health and Medical Research Council, Canberra

    Google Scholar 

  19. Gandhi GY, Nuttall GA, Abel MD et al (2007) Intensive intraoperative insulin therapy versus conventional glucose management during cardiac surgery. Ann Intern Med 146:233–243

    PubMed  Google Scholar 

  20. Ouattara A, Lecomte P, Le Manach Y et al (2005) Poor intraoperative blood glucose control is associated with a worsened hospital outcome after cardiac surgery in diabetic patients. Anesthesiology 103(4):687–694

    Article  PubMed  CAS  Google Scholar 

  21. Gandhi GY, Nuttall GA, Abel MD et al (2005) Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients. Mayo Clin Proc 80(7):862–866

    Article  PubMed  Google Scholar 

  22. Whipple AO, Frank VO (1937) Adenoma of islet cell tumours with hyperinsulinism. Am J Pathol 14:125–138

    Google Scholar 

  23. Vriesendorp TM, DeVries JH, Holleman F et al (2005) The use of two continuous glucose sensors during and after surgery. Diabetes Technol Ther 7(2):315–322

    Article  PubMed  CAS  Google Scholar 

  24. Lazar HL, Chipkin SR, Fitzgerald CA et al (2004) Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events [see comment]. Circulation 109(12):1497–1502

    Article  PubMed  CAS  Google Scholar 

  25. Gavin LA (1989) Management of diabetes mellitus during surgery. West J Med 151:1525–1529

    Google Scholar 

  26. Rady MY, Johnson DJ, Patel BM et al (2005) Influence of individual characteristics on outcome of glycaemic control in intensive care unit patients with and without diabetes mellitus. Mayo Clin Proc 80(12):1558–1567

    Article  PubMed  Google Scholar 

  27. Whitcomb BW, Pradhan EK, Pittas AG et al (2005) Impact of admission hyperglycaemia on hospital mortality in various intensive care unit populations. Crit Care Med 33(12):2772–2777

    Article  PubMed  Google Scholar 

  28. Freire AX, Bridges L, Umpierrez GE et al (2005) Admission hyperglycaemia and other risk factors as predictors of hospital mortality in a medical ICU population. Chest 128(5):3109–3116

    Article  PubMed  Google Scholar 

  29. Christiansen C, Toft P, Jorgensen HS et al (2004) Hyperglycaemia and mortality in critically ill patients: a prospective study. Intensive Care Med 30:1685–1688

    Article  PubMed  Google Scholar 

  30. Zerr KJ, Furnary AP, Grunkemeier GL et al (1997) Glucose control lowers the risk of wound infection in diabetics after open heart operations. Ann Thorac Surg 63:356–361

    Article  PubMed  CAS  Google Scholar 

  31. Carr JM, Sellke FW, Fey M et al (2005) Implementing tight glucose control after coronary bypass surgery. Ann Thorac Surg 80:902–909

    Article  PubMed  Google Scholar 

  32. Van den Berghe G, Wouters P, Weekers F et al (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345(19):1359–1367

    Article  PubMed  Google Scholar 

  33. Furnary A, Wu Y, Bookin SO (2004) Effect of hyperglycaemia and continuous intravenous insulin infusions on outcomes of cardiac surgical procedures: the Portland Diabetic Project. Endocr Pract 10(2):21–33

    PubMed  Google Scholar 

  34. NICE-SUGAR Study Investigators (2009) Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360(13):1283–1297

    Article  Google Scholar 

  35. Gore MO, McGuire DK (2009) The 10-year post-trial follow-up of the United Kingdom Prospective Diabetes Study (UKPDS): cardiovascular observations in context. Diab Vasc Dis Res 6(1):53–55

    Article  PubMed  Google Scholar 

  36. UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).[see comment]. Lancet 352(9131):837-853 [erratum: Lancet 1999 Aug 14;354(9178):602]

    Google Scholar 

  37. Nissen SE, Wolski K (2007) Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356(24):2457–2471

    Article  PubMed  CAS  Google Scholar 

  38. Genuth S, Alberti KG, Bennett P et al (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26(11):3160–3167

    Article  PubMed  Google Scholar 

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Disclosure

Dr. Wong has received honoraria from Sanofi Aventis, Novo Nordisk, and Lilly Pharmaceuticals for providing educational sessions.

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Corresponding author

Correspondence to Jennifer Wong.

Additional information

This study was conducted on behalf of the Southern Health Peri-operative Diabetes Management Guideline Group.

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Wong, J., Zoungas, S., Wright, C. et al. Evidence-based Guidelines for Perioperative Management of Diabetes in Cardiac and Vascular Surgery. World J Surg 34, 500–513 (2010). https://doi.org/10.1007/s00268-009-0380-0

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  • DOI: https://doi.org/10.1007/s00268-009-0380-0

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