Original Article

European Journal of Nuclear Medicine and Molecular Imaging

, Volume 36, Issue 3, pp 347-353

Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study

  • Andrew M. ScottAffiliated withCentre for PET, Austin HospitalLudwig Institute for Cancer Research, Austin Hospital Email author 
  • , Dishan H. GunawardanaAffiliated withCentre for PET, Austin Hospital
  • , Joseph WongAffiliated withSouthern X-Ray Clinics, The Wesley Hospital
  • , Ian KirkwoodAffiliated withDepartment of Nuclear Medicine and PET, Royal Adelaide Hospital
  • , Rodney J. HicksAffiliated withCentre for Molecular Imaging, Peter MacCallum Cancer Centre
  • , Ivan Ho ShonAffiliated withDepartment of Nuclear Medicine & PET, Liverpool Hospital
  • , Jayne E. RamshawAffiliated withAustralian and New Zealand Association of Physicians in Nuclear Medicine
  • , Peter RobinsAffiliated withWA PET/Cyclotron Service, Sir Charles Gairdner Hospital

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Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.


PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.


PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.


PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.


PET Gallium Low-grade lymphoma