European Journal of Nuclear Medicine and Molecular Imaging

, Volume 36, Issue 3, pp 347–353

Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study


    • Centre for PETAustin Hospital
    • Ludwig Institute for Cancer ResearchAustin Hospital
  • Dishan H. Gunawardana
    • Centre for PETAustin Hospital
  • Joseph Wong
    • Southern X-Ray ClinicsThe Wesley Hospital
  • Ian Kirkwood
    • Department of Nuclear Medicine and PETRoyal Adelaide Hospital
  • Rodney J. Hicks
    • Centre for Molecular ImagingPeter MacCallum Cancer Centre
  • Ivan Ho Shon
    • Department of Nuclear Medicine & PETLiverpool Hospital
  • Jayne E. Ramshaw
    • Australian and New Zealand Association of Physicians in Nuclear Medicine
  • Peter Robins
    • WA PET/Cyclotron ServiceSir Charles Gairdner Hospital
Original Article

DOI: 10.1007/s00259-008-0958-z

Cite this article as:
Scott, A.M., Gunawardana, D.H., Wong, J. et al. Eur J Nucl Med Mol Imaging (2009) 36: 347. doi:10.1007/s00259-008-0958-z



Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.


PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.


PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.


PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.


PETGalliumLow-grade lymphoma

Copyright information

© Springer-Verlag 2008