European Journal of Nuclear Medicine and Molecular Imaging

, Volume 36, Issue 3, pp 347–353

Positron emission tomography changes management, improves prognostic stratification and is superior to gallium scintigraphy in patients with low-grade lymphoma: results of a multicentre prospective study

Authors

    • Centre for PETAustin Hospital
    • Ludwig Institute for Cancer ResearchAustin Hospital
  • Dishan H. Gunawardana
    • Centre for PETAustin Hospital
  • Joseph Wong
    • Southern X-Ray ClinicsThe Wesley Hospital
  • Ian Kirkwood
    • Department of Nuclear Medicine and PETRoyal Adelaide Hospital
  • Rodney J. Hicks
    • Centre for Molecular ImagingPeter MacCallum Cancer Centre
  • Ivan Ho Shon
    • Department of Nuclear Medicine & PETLiverpool Hospital
  • Jayne E. Ramshaw
    • Australian and New Zealand Association of Physicians in Nuclear Medicine
  • Peter Robins
    • WA PET/Cyclotron ServiceSir Charles Gairdner Hospital
Original Article

DOI: 10.1007/s00259-008-0958-z

Cite this article as:
Scott, A.M., Gunawardana, D.H., Wong, J. et al. Eur J Nucl Med Mol Imaging (2009) 36: 347. doi:10.1007/s00259-008-0958-z

Abstract

Purpose

Positron emission tomography (PET) was evaluated in low-grade non-Hodgkin lymphoma (NHL) to determine its impact on staging and management and to compare PET and gallium scans.

Methods

PET resulted in management plan changes in 74 patients with untreated low-grade NHL stages I to III. Patient outcomes to 12 months were documented.

Results

PET identified additional lesions in 50% of patients, led to a change in stage in 32%, and had a significant impact on management in 34%. Inferior progression-free survival was noted in patients with additional lesions detected by PET (p=0.001) and in the 28% of patients upstaged by PET to stage III or IV (p=0.024). In a subset of 16 patients undergoing both PET and gallium scans, PET was found to be superior.

Conclusion

PET has a major role in the management of low-grade NHL in addition to its proven role in aggressive lymphoma.

Keywords

PETGalliumLow-grade lymphoma

Copyright information

© Springer-Verlag 2008