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Carbon paste electrode modified with copper(II) phosphate immobilized in a polyester resin for voltammetric determination of l -ascorbic acid in pharmaceutical formulations

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Abstract

A carbon paste electrode modified with copper(II) phosphate immobilized in a polyester resin (CuP-Poly) is proposed for voltammetric determination of l -ascorbic acid in pharmaceutical formulations. The modified electrode allows the detection of l -ascorbic acid at lower anodic potentials than observed at unmodified electrodes. Several parameters that can influence the voltammetric response of the proposed electrode such as carbon paste composition, pH, scan rate, and possible interference were investigated. The peak current was proportional to the concentration of ascorbic acid in the range 2.0×10−5 to 3.2×10−3 mol L−1 with a detection limit of 1.0×10−5 mol L−1. The stability and repeatability of the electrode for the determination of l -ascorbic acid are also discussed. Amperometric response was also recorded for electrocatalytic oxidation of the l -ascorbic acid. Concentrations of the vitamin C in pharmaceutical formulations (tablets) measured using the modified electrode and a titrimetric method are in agreement at the 95% confidence level and within an acceptable range of error.

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Acknowledgments

The authors are grateful for financial support from Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP (Processes 00/02997-2 and 99/03280-5).

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Authors and Affiliations

  1. Departamento de Química, Centro de Ciências Exatas e de Tecnologia, Universidade Federal de São Carlos, Caixa Postal 676, CEP 13.560-970, São Carlos, SP, Brazil

    Marcos F. S. Teixeira, Luiz A. Ramos & Orlando Fatibello-Filho

  2. Departamento de Química e Física Molecular, Instituto de Química de São Carlos—USP, São Carlos, SP, Brazil

    Éder T. G. Cavalheiro

Authors
  1. Marcos F. S. Teixeira
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  2. Luiz A. Ramos
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  3. Orlando Fatibello-Filho
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  4. Éder T. G. Cavalheiro
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Correspondence to Marcos F. S. Teixeira.

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Teixeira, M.F.S., Ramos, L.A., Fatibello-Filho, O. et al. Carbon paste electrode modified with copper(II) phosphate immobilized in a polyester resin for voltammetric determination of l -ascorbic acid in pharmaceutical formulations. Anal Bioanal Chem 376, 214–219 (2003). https://doi.org/10.1007/s00216-003-1866-5

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  • DOI: https://doi.org/10.1007/s00216-003-1866-5

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