Medicinal Chemistry Research

, Volume 23, Issue 8, pp 3607–3616

Recent progress and challenges in the computer-aided design of inhibitors for influenza A M2 channel proteins

Review Article

DOI: 10.1007/s00044-014-0964-6

Cite this article as:
Tran, L. & Le, L. Med Chem Res (2014) 23: 3607. doi:10.1007/s00044-014-0964-6

Abstract

The M2 channel protein has become an attractive target for the design of new drugs against influenza because it plays a crucial role in the replication cycle of influenza A virus. Several adamantane-based drugs have recently been developed to inhibit the activity of the M2 channel and overcome the drug resistance issues observed in amantadine and rimantadine. Computer-aided drug design continues to play a critical role in the drug discovery process in terms of its contribution to the identification and development of new therapeutic agents. Scientists working in this field are currently facing significant challenges with regard to creating novel platforms capable of enhancing our understanding of these proteins, with computational techniques being used to search for new potential drugs against influenza. This review provides a summary of recent progress in drug discovery toward the development therapeutic agents targeting M2 channel proteins. It is hoped that this review will stimulate the development of new strategies for overcoming drug resistance problems and encourage the design of new and improved drugs against influenza A virus.

Keywords

M2 channel proteinDrug developmentInfluenza A virusInhibition mechanismStructural characteristicsM2 inhibitor

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.School of BiotechnologyHo Chi Minh International UniversityHo Chi Minh CityVietnam
  2. 2.Life Science LaboratoryInstitute for Computational Science and TechnologyHo Chi Minh CityVietnam