Abstract
Five distinct organic compounds with protected and unprotected phenolic hydroxyl groups were screened for their α-glucosidase inhibitory potential. Of these compounds, 2,4,6-trihydroxybenzaldehyde (THB) showed the strongest noncompetitive α-glucosidase inhibition (IC50 = 4.60 μM) and the most powerful antioxidant activity (DPPH assay) (IC50 = 71.4 μM) in vitro. In in vivo studies, THB significantly reduced blood glucose levels in normal and diabetic rats after glucose load compared to maltose load.
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This research was financially supported by the National Research Foundation of Korea.
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Sancheti, S., Sancheti, S., Bafna, M. et al. 2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats. Med Chem Res 20, 1181–1187 (2011). https://doi.org/10.1007/s00044-010-9461-8
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DOI: https://doi.org/10.1007/s00044-010-9461-8