Cellular and Molecular Life Sciences

, Volume 70, Issue 22, pp 4201–4211

Regulation and dysregulation of astrocyte activation and implications in tumor formation

Review

DOI: 10.1007/s00018-013-1274-8

Cite this article as:
Yang, C., Rahimpour, S., Yu, A.C.H. et al. Cell. Mol. Life Sci. (2013) 70: 4201. doi:10.1007/s00018-013-1274-8

Abstract

Astrocytic activation is a cellular response to disturbances of the central nervous system (CNS). Recent advances in cellular and molecular biology have demonstrated the remarkable changes in molecular signaling, morphology, and metabolism that occur during astrocyte activation. Based on these studies, it has become clear that the astrocyte activation process is regulated by a variety of signaling pathways, which result in metabolic support, wound healing and scar formation. While normal astrocyte activation pathways drive homeostasis and/or repair in the CNS, dysregulation of these pathways can lead to astrocyte abnormalities, including glioma formation with similar phenotypes as reactive astrocytes. We review the principle pathways responsible for astrocytic activation, as well as their potential contribution to tumor formation in the CNS.

Keywords

Glia Astrocytoma Gliosis Brain tumor Tumorigenesis Central nervous system 

Copyright information

© Springer Basel (outside the USA) 2013

Authors and Affiliations

  1. 1.Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of HealthBethesdaUSA
  2. 2.Neuroscience Research Institute, Key Laboratory of Neuroscience (Ministry of Education), Key Laboratory for Neuroscience (Ministry of Public Health), Department of Neurobiology, School of Basic Medical Sciences, Health Science CenterPeking UniversityBeijingChina

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