Cellular and Molecular Life Sciences CMLS

, Volume 58, Issue 5, pp 737–747

Cytochromes P450 and metabolism of xenobiotics

  • P. Anzenbacher
  • E. Anzenbacherová

DOI: 10.1007/PL00000897

Cite this article as:
Anzenbacher, P. & Anzenbacherová, E. CMLS, Cell. Mol. Life Sci. (2001) 58: 737. doi:10.1007/PL00000897

Abstract.

Cytochromes P450 (henceforth P450s) are involved in a variety of metabolic and biosynthetic processes. The number of known P450 enzymes exceeds 1000, while the endogenous substrates of most of them remain unknown. All P450 enzymes exhibit similarity in their structure and general mechanism of action; however, there are significant differences in the detailed function of individual enzymes as well as in the structures and properties of their active sites. This review discusses the properties of the most important P450 enzymes taking part in drug metabolism in humans. P450 3A4 is of paramount importance, because it is the most abundant P450 in the human liver and is known to metabolize the majority of drugs whose biotransformation is known. Genetically dependent variabilities of individual P450 activities and levels are described, documenting the importance of pharmacogenetics aimed at explaining differences in the response of the organism to various drugs.

Key words. Cytochromes P450; CYP; drug metabolism; xenobiotic.

Copyright information

© Birkhäuser Verlag, 2001

Authors and Affiliations

  • P. Anzenbacher
    • 1
  • E. Anzenbacherová
    • 1
  1. 1. Institute of Pharmacology and Institute of Medical Chemistry and Biochemistry, Faculty of Medicine, Palacký University, Hněvotínská 3, 775 15 Olomouc (Czech Republic), e-mail: anzen@tunw.upol.czCZ