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One-Pot synthesis of dihydropyrimidinones by dodecylphosphonic acid as solid Bronsted Acid Catalyst under Solvent-Free Conditions via Biginelli condensation

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Abstract

Dodecylphosphonic acid is a solid Bronsted acid that catalyzes efficiently the preparation of dihydropyrimidinones by Biginelli condensation under solvent-free conditions. This protocol offers several advantages including high yields, short reaction times, easy work-up, and use of cheap, relatively moderate acidic and safe catalyst.

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Authors and Affiliations

  1. Department of Chemistry, Shiraz University, Shiraz, 71454, I.R. Iran

    S. Ghassamipour & A. R. Sardarian

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  1. S. Ghassamipour
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  2. A. R. Sardarian
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Correspondence to A. R. Sardarian.

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Ghassamipour, S., Sardarian, A.R. One-Pot synthesis of dihydropyrimidinones by dodecylphosphonic acid as solid Bronsted Acid Catalyst under Solvent-Free Conditions via Biginelli condensation. JICS 7, 237–242 (2010). https://doi.org/10.1007/BF03245884

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  • DOI: https://doi.org/10.1007/BF03245884

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