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Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rat

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Abstract

Effects of low level lead (Pb) exposure on the time-dependent organ-tissue distribution of zinc (Zn), iron (Fe), copper (Cu), and calcium (Ca) were investigated in the neonatal rat. Pups were exposed to Pb acetate (50 mg/kg) via intragastric intubation at 3-d intervals from day 6 postpartum to day 18. This level of Pb exposure had no significant effect on body weight. Exposure to Pb resulted in an alteration of the normal, time-dependent organ distribution of the essential elements and significantly lower concentrations of Zn were found in brain, liver, kidney, and femur of Pb-treated animals.

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Authors and Affiliations

  1. Nutrition Program, College of Human Development, The Pennsylvania State University, University Park, 16801, Pennsylvania

    Gregory D. Miller & Ellen Koperek

  2. Center for Air Environment Studies, Fenske Laboratory, The Pennsylvania State University, University Park, 16801, Pennsylvania

    Thomas F. Massaro & Edward J. Massaro

Authors
  1. Gregory D. Miller
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  2. Thomas F. Massaro
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  3. Ellen Koperek
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  4. Edward J. Massaro
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Miller, G.D., Massaro, T.F., Koperek, E. et al. Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rat. Biol Trace Elem Res 6, 519–530 (1984). https://doi.org/10.1007/BF02987205

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  • DOI: https://doi.org/10.1007/BF02987205

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