Abstract
Some Mannich bases of Antineoplaston A10 which is antitumor agent under clinical investigation were synthesized and tested for cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.
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Burzynski, S. R., Biologically active peptides in human urine 1. Isolation of a group of medium-sized peptides.Physiol. Chem. Phys., 5, 437–447 (1973).
Burzynski, S. R. and Georgiades, J. Effect of urinary peptides on DNA, RNA and protein synthesis in normal and neoplastic cells.Fed. Proc., 32, 766 (1973).
Burzynski, S. R., Antineoplastons: Biochemical defense against cancer.Physiol. Chem. Phys., 8, 275–279 (1976).
Burzynski, S. R., Hendry, L. B., Mohabbat, M. O., Liau, M. C., Khalid, M. and Burzynski, B, Purification, structure determination, synthesis and animal toxicity studies of antineoplaston A10.Proc. 13th Intil. Cong. Chemother(Vienna) 17, PS 12. 4. 11−4 (1983).
Burzynski, S. R., Mohabbat, M. O. and Burzynski, B. Toxicology studies of oral formulation of antineoplaston A10 in cancer patients.Drug Exp. Clin. Res., 10, 611–619 (1984).
Burzynski, S. R. Antineoplaston AS2-1.Drugs of the future 11, 361–363 (1986a).
Burzynski, S. R., Synthetic antineoplastons and analogs.Drugs of the future, 11, 679–688 (1986b).
Burzyski, S. R., Methods for preparing 3-[N-Phenyl-acetylaminopiperidine]-2,6-dione. U.S. Patent 4,918, 193 (1990).
Burzynski, S. R., Substituted piperidnediones, substituted phenylacetic acids, and substututed phenylacetyl-glutamines for treatment of AIDS. U.S. Patent 5, 089,508 (1992a).
Burzynski, S. R., Urine peptides for the treatment of Parkinson's disease, PCT Int. Appl. WO 9204,043, 19 Mar. (1992b).
Hendry, L. B., Diamond, A. H., Diamond, B. I. and Ewing D. E., Use of 3-N-phenylacetylamino-2,6-piperidinedione for treatment of neuropsychiatric disorsers, U.S. Patent, 4,705,796 (1987).
Hendry L B., Chu, C. K. and Mahesh, V. B., Preparation of 3-phenylacetaminopiperidind-2,6-diones as cytocytic agents, PCT Int. Appl. WO 91 16,309, 31 Oct. 1991, US Appl. 508,839, 12 Apr. (1990).
Jun, C. C., Han, L. S., Cai, F. T., Toshihito, K., Toshoyuki, M and Toshiharu, N., Synthesis and antitumor properties of N1-acyloxymethyl derivatives of bis(2,6-dioxopiperazines).Chem. Pharm. Bull. 37(11) 2976–2983 (1987).
Werner, W and Fritzsche, Potentiellecytostatica durch aminomethylierung NH-acides hypnotika.Archiv der Pharmazie, 302 Bd, 188–196 (1969).
Xu Wenfang, Zhao Yulan, Yuan Yumei and Yu Yonghui, Improved preparation of antitumor agent antineoplaston A10.Pharmaceutical Industry, 19(5), 198–199 (1988).
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Choi, BG., Seo, HK., Chung, BH. et al. Synthesis of Mannich bases of Antineoplaston A10 and their antitumor activity. Arch. Pharm. Res. 17, 467–469 (1994). https://doi.org/10.1007/BF02979127
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DOI: https://doi.org/10.1007/BF02979127