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Studies of biochemical parameters in breast cancer with and without metastasis

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Abstract

The study includes 102 confirmed cases of carcinoma breast with and without metastasis and 25 healthy non-pregnant females. They were evaluated for blood levels of Ferritin, GSH, LDH, ALP, GGT and Hb before and 21 days after mastectomy. A significant increase (p<0.001) was observed in ferritin, LDH and GSH levels in cancer patients without metastasis in comparison to normal control subjects. Patients with metastasis had further elevated (p<0.001) levels of Ferritin, ALP and GGT as compared to non-metastatic patients. Mastectomy in both the cases i.e. with and without metastasis resulted in non-significant decrease in all the biochemical parameters suggesting that longer follow up could confirm post surgery decrease in the biochemical parameters. The results of the study suggest cost effective, usefulness of Ferritin, ALP, GGT and GSH/Hb ratio in differentiating breast cancer patients with and without metastasis which can be assayed in smaller laboratories.

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References

  1. Sharma, B.K. and Ray, A. (2000) Breast and Prostate Cancer. IJCB, 15, (Suppl.), 110–17.

    Google Scholar 

  2. Linblom, A. and Liljegreen, A. (2000) Tumor markers in malignancies. B.M.J., 320, 424–27.

    Article  Google Scholar 

  3. Burti’s, C.A. and Ashwood, E.R. (1994) Tietz textbook of clinical chemistry. Second edition, W.B. Saunders Company, Philadelphia pp. 814–15, 813, 848–49, 897–99.

    Google Scholar 

  4. Sadig, R.E.E. and Lai, L.C. (2000) Oestrogens and breast cancer. Clin. Biochemist. Rev. 21, 93–99

    Google Scholar 

  5. Beutler, E. (1971) Red cell metabolism: A manual of biochemical methods. Grune and Stration. New York, 103–5.

    Google Scholar 

  6. Worwood, M. (1986) Serum Ferritin. Clin. Sci. 70, 215–20.

    PubMed  CAS  Google Scholar 

  7. Dacie, J.V. and Lewis, S.M. (1994) Practical haematology, Churchill Livingston, Edinburgh, 8th ed., pp. 49–82.

    Google Scholar 

  8. Guner, G., Kirkali, G., Yenisey, C., Tore, I.R. (1992) Cytosol and Serum ferritin in breast carcinoma. Cancer Lett. Dec. 24, 67 (2–3), 103–12.

    Article  CAS  Google Scholar 

  9. Perquin, M., Oster, T., Maul, A., Froment, N., Untereiner, M. and Bagrel, D. (2001) The Glutathione related detoxification system is increased in human breast cancer in correlation with clinical and histopathological features. J. Can. Res. Clin. Oncol. 127(6), 368–74.

    Article  CAS  Google Scholar 

  10. Aboughalia, A.H. and Fouad, I.M. (2000) Glutathione and its metabolizing enzymes in patients with different benign and malignant diseases. Clin. Biochem. 33 (8), 657–62.

    Article  CAS  Google Scholar 

  11. Kher, A., Maghe, G. and Deshpande, A. (1997) Significance of serum ferritin and lactate dehydrogenase in benign and malignant disease of breast. Indian J. Pathol. Microbiol. 40 (3), 321–6.

    PubMed  CAS  Google Scholar 

  12. Albuquer que, K.V., Price, M.R., Badley, R.A., Jonrup, I., Pearson, D., Blamey, R.W. and Robertson, J.F. (1995) Pre-treatment serum levels of tumour markers in metastatic breast cancer: a prospective assessment of their role in predicting response to therapy and survival. Eur. J. Surg. Oncol. 21(5), 504–9.

    Article  CAS  Google Scholar 

  13. Letiagin, V.P. and Vysotskaia, I.V. (1995) Tumor marker CE A, CA 15-3, MCA, TPA, Ferritin and PTH in the diagnosis and monitoring of primary breast cancer. Vestin Ross Akad Med Nauk, 4, 10–14.

    Google Scholar 

  14. Aydiner, A., Topuz, E., Disci, R., Yasasever, V., Dincer, M., Dincol, K. and Bilge, N. (1994) Serum Tumor marker for detection of bone metastasis in breast cancer patients. Acta Oncol, 33 (2), 181–86.

    Article  PubMed  CAS  Google Scholar 

  15. Kokocinska, D., Widala, E., Donocik, J. and Nolewajka, E. (1999) The value of evaluating tumor markers: CA15-3 and ferritin in blood serum of patients grouped as “high risk” for breast cancer. Przegl Lek. 56 (10), 664–67.

    PubMed  CAS  Google Scholar 

  16. Elliott, R.L., Elliott, M.C., Wang, F. and Head, J.F. (1993) Breast carcinoma and the role of iron metabolism. A cytochemical tissue, culture, and ultrastructural study. Ann. N.Y. Acad. Sci. 698, 159–66.

    Article  PubMed  CAS  Google Scholar 

  17. Devlin, T.M. (1997) Textbook of Biochemistry with clinical correlations. Fourth ed. Wiley-Liss. New York p. 484.

    Google Scholar 

  18. Sharabasy, M.M., Dosoky, I., Horia, H. and Khalaf, A.H. (1993) Elevation of glutathione, glutathione reductase and nucleic acids in both normal tissues and tumor of breast cancer patients. Cancer Lett. 72, 11–15.

    Article  PubMed  Google Scholar 

  19. Murray, G.I., Burke, M.D. and Ewen, S.W.B. (1987) Glutathione localization in benign and malignant human breast lesions. Br. J. Cancer 55, 605–9.

    PubMed  CAS  Google Scholar 

  20. Sieger, S., Bose, C.P., Younes, H., Thies, E., Hoppenkamp, S.R. and Younes, E. (1984) Glutathione and GSH dependent enzymes in the tumours and non-tumours mucosa of the human colon and rectum. J. Cancer Res. Clin. Oncol. 107, 288–340.

    Google Scholar 

  21. Beutler, E. and Gelbart (1985). Plasma glutathione in health and in patients with malignant disease. J. Lab. Clin. Med. 105, 581–84.

    PubMed  CAS  Google Scholar 

  22. Kumaraguruparan, R., Subapriya, R., Kabalimoorthy, J. and Nagini, S. (2002) Antioxidant profile in the circulation of patients with fibroadenoma and adenocarcinoma of the breast. Clin. Biochem. 35(4), 275–79.

    Article  PubMed  CAS  Google Scholar 

  23. Vaid, P. and Sharma, D.C. (1974) a clinico biochemical study of phosphohexose isomerase, allesterase and SH group. Ind. J. Can. Dec., 448–50.

  24. Vanhoof, V.O., Vanoostrom, A.T., Lepoutre, L.G. and DeBroe, M.E. (1992) Alkaline phosphates isoenzyme patterns in malignancy disease. Clin. Chem. 38, 2546–2551.

    CAS  Google Scholar 

  25. Stieber, P., Mangal, D., Ritzke, C., Rossler, N., Kirsch, C.M. and Eiermann, W. (1992) Significance of bone alkaline phosphatase. CA15-3 and CEA in detection of bone metastasis during follow up of patients suffering from breast carcinoma. Eur. J. Clin. Chem. Clin. Biochem. 30, 809–14.

    PubMed  CAS  Google Scholar 

  26. Ramaswamy, G., Rao, V.R., Krishnamoorthy, L., Ramesh, G., Gomathy, R. and Renukadevi, D. (2000) Serum levels of bone alkaline phosphatase in breast and prostate cancer with bone metastasis. Indian J. Clin. Biochem. 15 (2), 110–13.

    Article  CAS  Google Scholar 

  27. Lamerz, R., Stieber, P. and Fateh-Moghadam, A. (1993) Serum marker combinations in human breast cancer (review).In Vivo, 7 (613), 607–13.

    PubMed  CAS  Google Scholar 

  28. Sharma, D.C., Mishra, S. and Sharma, P. (2001) Blood Glutathione level in breast cancer patients before and after surgery. J. Obst. Gyn. India. 51 (6), 150–51.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Deptt. Of Biochemistry, SMS Medical College, 302004, Jaipur

    Sandhya Mishra, D. C. Sharma & Praveen Sharma

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  1. Sandhya Mishra
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  2. D. C. Sharma
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  3. Praveen Sharma
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Correspondence to Praveen Sharma.

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Mishra, S., Sharma, D.C. & Sharma, P. Studies of biochemical parameters in breast cancer with and without metastasis. Indian J Clin Biochem 19, 71–75 (2004). https://doi.org/10.1007/BF02872394

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