Advances in Therapy

, Volume 19, Issue 5, pp 209-218

First online:

Arnica montana gel in osteoarthritis of the knee: An open, multicenter clinical trial

  • Otto KnueselAffiliated withDepartment of Rheumatology, Valens Clinic for Rheumatism
  • , Michel WeberAffiliated withBioforce AG
  • , Andy SuterAffiliated withBioforce AG

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This open multicenter trial investigated the safety and efficacy of anArnica montana fresh plant gel, applied twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee. After 3 and 6 weeks, significant decreases in median total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were evident in the intention-to-treat and per-protocol populations (both P<.0001). Scores on the pain, stiffness, and function subscales also showed significant reductions at these timepoints. The overall local adverse-event rate of 7.6% included only one allergic reaction. Sixty-nine patients (87%) rated the tolerability of the gel as “good” or “fairly good,” and 76% would use it again. Topical application ofArnica montana gel for 6 weeks was a safe, well-tolerated, and effective treatment of mild to moderate OA of the knee.


arnica clinical trial osteoarthritis WOMAC