Advances in Therapy

, 19:209

Arnica montana gel in osteoarthritis of the knee: An open, multicenter clinical trial


  • Otto Knuesel
    • Department of RheumatologyValens Clinic for Rheumatism
  • Michel Weber
    • Bioforce AG
  • Andy Suter
    • Bioforce AG

DOI: 10.1007/BF02850361

Cite this article as:
Knuesel, O., Weber, M. & Suter, A. Adv Therapy (2002) 19: 209. doi:10.1007/BF02850361


This open multicenter trial investigated the safety and efficacy of anArnica montana fresh plant gel, applied twice daily, in 26 men and 53 women with mild to moderate osteoarthritis (OA) of the knee. After 3 and 6 weeks, significant decreases in median total scores on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were evident in the intention-to-treat and per-protocol populations (both P<.0001). Scores on the pain, stiffness, and function subscales also showed significant reductions at these timepoints. The overall local adverse-event rate of 7.6% included only one allergic reaction. Sixty-nine patients (87%) rated the tolerability of the gel as “good” or “fairly good,” and 76% would use it again. Topical application ofArnica montana gel for 6 weeks was a safe, well-tolerated, and effective treatment of mild to moderate OA of the knee.


arnicaclinical trialosteoarthritisWOMAC
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