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Acetylsalicylic acid impedes human endothelial cell activation mediated by soluble products derived from a human lymphoma

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Abstract

Introduction

Acetylsalicylic acid intake has been reported to reduce the risk of development and dissemination of some tumours. To-date, the mechanism for this protective effect remains unknown.

Materials and methods

We have demonstrated, previously, that soluble products secreted by tumour cells activate human endothelial cells in a manner that is dependent on the nuclear factor-kB (NF-κB) transcription factor. Whether the protection conferred by acetylsalicylic acid is via its effect on cyclo-oxygenase or on the activation of the NF-κB, is unclear.

Results

In testing this system we observed that acetylsalicylic acid blocked the endothelial activation induced by soluble products secreted by tumour cell by: a) impeding the translocation of NF-κB; b) reducing the expresion of ICAM-1, and c) reducing the capacity of endothelial cells to adhere to the human lymphoma U937.

Conclusion

These results can explain, in part, the mechanism by which acetylsalicytic acid impedes the dissemination of malignant tumours.

Resumen

Introducción

En seres humanos, la ingestión de ácido acetilsalicílico reduce el riesgo de, desarrollo tumoral y la diseminación de algunos tumores.

Materiales y métodos

Previamente hemos demostrado que los productos solubles secretados por células tumorales activan a las células endoteliales humanas de una manera dependiente del factor de transcripción NF-κB. Actualmente, se desconoce el mecanismo de esta protección, y si está relacionada con los effectos del ácido acetilsalicílico sobre la ciclooxigenasa, o sobre la activación de NF-κB.

Resultados

Al probar el efecto del mism, o sobre este sistem a encontramos que bloquea la activación endotelial inducida por productos solubles secretados por células tumorales al: a) interferir con la translocación de NF-κB; b) reducir la expresión de ICAM-1, 1, y c) reducir la capacidad de células endoteliales de adherir al linfoma humano U937.

Conclusión

Estos resultados podrían explicar el mecanismo por el cual el ácido acetilsalicílico interfiere con la diseminación de tumores malignos.

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Authors and Affiliations

  1. Departamento de Biología Celular, Instituto de Fisiología Celular, Universidad Autónoma de México, Copilco Universidad, México, DF

    Adriana Estrada-Bernal, Marco Antonio Alcántara-Meléndez, Criselda Mendoza-Milla, José Luis Ventura-Gallegos & Alejandro Zentella-Dehesa

  2. Instituto de Investigación en Biología Experimental, Universidad de Guanajuato Gto, Gto, México

    María del Rosario Quiroz-Méndez & Myrna Sabanero-López

Authors
  1. Adriana Estrada-Bernal
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  2. Marco Antonio Alcántara-Meléndez
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  3. Criselda Mendoza-Milla
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  4. José Luis Ventura-Gallegos
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  5. María del Rosario Quiroz-Méndez
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  6. Myrna Sabanero-López
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  7. Alejandro Zentella-Dehesa
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Correspondence to Adriana Estrada-Bernal or Alejandro Zentella-Dehesa.

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Estrada-Bernal, A., Alcántara-Meléndez, M.A., Mendoza-Milla, C. et al. Acetylsalicylic acid impedes human endothelial cell activation mediated by soluble products derived from a human lymphoma. Rev Oncol 5, 458–464 (2003). https://doi.org/10.1007/BF02710369

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  • DOI: https://doi.org/10.1007/BF02710369

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