Skip to main content
SpringerLink
Log in

Protein-losing gastroenteropathy: Concepts derived from lymphangiography

  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Summary

Lymphangiograms in 2 patients with protein-losing gastroenteropathy showed abnormalities of both abdominal and lower-extremity lymphatics.

With the application of lymphangiography, the generalized nature of the lymphatic dysplasia in primary protein-losing gastroenteropathy has become evident.

Striking lymphangiographic similarities between primary protein-losing gastroenteropathy and primary lymphedema suggest that both entities are part of a continuous spectrum of lymphatic dysplasias.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Albright, F., Bartter, F. C, andForbes, A. P. The fate of human serum albumin administered intravenously to a patient with idiopathic hypoalbuminemia and hypoglobulinemia.Tr. A. Am. Physicians 62:204, 1949.

    Google Scholar 

  2. Kinsell, L. W., Marcen, S., Tarver, H., Frantz, J. McB., Flanagan, E. K., Hutchin, M. D., Michaels, G. D., andMcCallie, D. P. Studies in methionine metabolism. III. The fate of intravenously administered S35 labeled methionine in normal adult males, in patients with chronic hepatic disease, “idiopathic hypoproteinemia,” and Cushing's Disease.J. Clin.Invest. 29:238, 1950.

    Google Scholar 

  3. Gitlin, D., Janeway, C. A., andFarr, L. E. Studies on the metabolism of plasma proteins in the nephrotic syndrome I albumin, and globulin and iron binding globulin.J. Clin. Invest. 35:44, 1956.

    PubMed  Google Scholar 

  4. Schwartz, M., andThomsen, B. Idiopathic or hypercatabolic hypoproteinemia.Brit. M. J. 1:14, 1957.

    Google Scholar 

  5. Steinfeld, J. L., Davidson, J. D., andGordon, R. S. A mechanism for hypoalbuminemia in patients with ulcerative colitis and regional enteritis.J. Clin. Invest. 36:931, 1957.

    Google Scholar 

  6. Citrin, Y., Sterling, K., andHalsead, J. A. The mechanism of hypoproteinemia associated with giant hypertrophy of the gastric mucosa.N. England J. Med. 257:906, 1957.

    Google Scholar 

  7. Gordon, R. S. Exadative enteropathy, abnormal permeability of the gastrointestinal tract demonstrable with labelled polyvinylpyrrolidone.Lancet 1:325, 1959.

    Article  PubMed  Google Scholar 

  8. Waldman, T. A., Steinfeld, J. L. Dutcher, T. F., Davidson, J. D., andGordon, R. S. The role of the gastrointestinal system in “idiopathic hypoproteinemia”.Gastroenterology 41:197, 1961.

    PubMed  Google Scholar 

  9. Pomerantz, M., andWaldman, T. A. Systemic lymphatic abnormalities associated with gastrointestinal protein loss secondary to intestinal lymphangiectasia.Gastroenterology 45:703, 1963.

    PubMed  Google Scholar 

  10. Mistilis, S. P., Skyring, A. P., andStephens, D. D. Intestinal lymphangiectasia mechanism of enteric loss of plasma, protein and fat.Lancet 1:77, 1965.

    Article  Google Scholar 

  11. Wallace, S., Jackson, L., Dodd, G. D., andGreening, R. R. Lymphatic dynamics in certain abnormal states.Am. J. Roentgenol. 91:1187, 1964.

    Google Scholar 

  12. Kinmonth, J. B., Taylor, G. W., Tracy, G. D., andMarsh, J. D. Primary lymphedema: Clinical and lymphangiographic studies of a series of 107 patients in which the lower limbs were affected.Brit. J. Surg. 45:1, 1957.

    PubMed  Google Scholar 

  13. Stoelinga, G. B. A., van Munster, P. J. J.. andSloof, J. P. Chylous effusions into the intestine in a patient with protein losing gastroenteropathy.Pediatrics 31:1011, 1963.

    PubMed  Google Scholar 

  14. Waldman, T. A. Gastrointestinal protein loss demonstrated by Cr51 labelled albumin.Lancet 2:121, 1961.

    Article  PubMed  Google Scholar 

  15. Pomerantz, M., Herdt, J. R. L., Rockoff, S. D. andKetcham, A. S. Evaluation of the functional anatomy of the thoracic duct by lymphangiography.J. Thoracic Cardiovasc. Surg. 46:568, 1963.

    Google Scholar 

  16. Jeffries, G. H., Chapman, A. andSleisenger, M. H. Low fat diet in intestinal lymphangiectasia.N. England J. Med. 270:761, 1964.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. From the Departments of Radiology and Internal Medicine (Gastroenterology Section), The University of Michigan Medical School and the Clinical Research Unit of the University of Michigan Hospital, Ann Arbor, Mich.

    Joseph J. Bookstein M.D., Arthur B. French M.D. & H. Marvin Pollard M.D.

Authors
  1. Joseph J. Bookstein M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arthur B. French M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Marvin Pollard M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported in part by Grants C3312 from the National Cancer Institute, AM-07120 from the National Institute of Arthritis and Metabolic Diseases, and FR-42 from the General Clinical Research Centers Branch, Division of Research Facilities and Resources, National Institutes of Health, U. S. Public Health Service.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bookstein, J.J., French, A.B. & Pollard, H.M. Protein-losing gastroenteropathy: Concepts derived from lymphangiography. Digest Dis Sci 10, 573–581 (1965). https://doi.org/10.1007/BF02237631

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02237631

Keywords

Search

Navigation