Prospective study of the impact of broad-spectrum antibiotics on the yeast flora of the human gut
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- Samonis, G., Gikas, A., Toloudis, P. et al. Eur. J. Clin. Microbiol. Infect. Dis. (1994) 13: 665. doi:10.1007/BF01973996
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The effects of four antibiotics on the yeast flora of the human gut were evaluated. Forty adult cancer patients who received therapy with amoxicillin-clavulanate, ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin were studied prospectively. Quantitative stool cultures for yeasts were performed immediately before, at the end of and one week after the end of the antibiotic treatment. Amoxicillin-clavulanate caused a higher and more persistent increase in gastrointestinal colonization by yeasts compared to ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin. The present results are similar to those obtained in a mouse model of gastrointestinal colonization byCandida albicans when the same antibiotics were used.