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Prospective study of the impact of broad-spectrum antibiotics on the yeast flora of the human gut

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Abstract

The effects of four antibiotics on the yeast flora of the human gut were evaluated. Forty adult cancer patients who received therapy with amoxicillin-clavulanate, ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin were studied prospectively. Quantitative stool cultures for yeasts were performed immediately before, at the end of and one week after the end of the antibiotic treatment. Amoxicillin-clavulanate caused a higher and more persistent increase in gastrointestinal colonization by yeasts compared to ciprofloxacin, sulfamethoxazole-trimethoprim or ampicillin. The present results are similar to those obtained in a mouse model of gastrointestinal colonization byCandida albicans when the same antibiotics were used.

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Authors and Affiliations

  1. Department of Medicine, The University of Crete, Heraklion, 7110, Crete, Greece

    G. Samonis, A. Gikas, P. Toloudis, G. Vrentzos & N. Tsaparas

  2. Department of Bacteriology, Parasitology, Zoonoses and Tropical Medicine, The University of Crete, Heraklion, 7110, Crete, Greece

    S. Maraki & Y. Tselentis

  3. Department of Medical Specialties, Section of Infectious Diseases, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 47, 77030, Houston, Texas, USA

    G. Bodey

Authors
  1. G. Samonis
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  2. A. Gikas
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  3. P. Toloudis
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  4. S. Maraki
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  5. G. Vrentzos
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  6. Y. Tselentis
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  7. N. Tsaparas
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  8. G. Bodey
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Samonis, G., Gikas, A., Toloudis, P. et al. Prospective study of the impact of broad-spectrum antibiotics on the yeast flora of the human gut. Eur. J. Clin. Microbiol. Infect. Dis. 13, 665–667 (1994). https://doi.org/10.1007/BF01973996

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  • DOI: https://doi.org/10.1007/BF01973996

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