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Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94

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Somatic Cell and Molecular Genetics

Abstract

The murine tumor rejection antigen gp96 (TRA1, mapped to mouse chromosome 10) is a member of the heat shock protein family. Using a fragment of the murine gp96 cDNA as a probe, three gp96-related human genes have been isolated and structurally characterized. They have been mapped to human chromosomes 1 (p22), 12 (q24.2 → q24.3), and 15 (q25 → q26) by Southern blot hybridization and in situ hybridization of gene-specific probes. Only one of the genes, designatedTRA1 (human chromosome 12) is a coding gene; the other genes (TRA1P1 andTRAP2) appear to be independently derived, processed pseudogenes.

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Authors and Affiliations

  1. Department of Pharmacology, Mount Sinai School of Medicine of CUNY, Box 1215, 10029, New York, New York

    Robert G. Maki & Pramod K. Srivastava

  2. Department of Human Genetics, Roswell Park Memorial Institute, 14263, Buffalo, New York

    Roger L. Eddy Jr., Mary Byers & Thomas B. Shows

Authors
  1. Robert G. Maki
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  2. Roger L. Eddy Jr.
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  3. Mary Byers
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  4. Thomas B. Shows
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  5. Pramod K. Srivastava
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Maki, R.G., Eddy, R.L., Byers, M. et al. Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94. Somat Cell Mol Genet 19, 73–81 (1993). https://doi.org/10.1007/BF01233956

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  • DOI: https://doi.org/10.1007/BF01233956

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