Summary
In a 79-year-old woman, the progression of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) to malignant lymphoma was observed within one year after diagnosis. Three biopsy specimens from lymph nodes and one tonsil, obtained at intervals of several months, showed an increasing destruction of the tissue architecture and the development of histological criteria for a lymphoid neoplasm, which at autopsy was confirmed as a malignant non-Hodgkin's lymphoma. The demonstration of a chromosomally abnormal clone in lymph node derived and the laboratory findings were in agreement with the histological changes and the sequential clinical deterioation. Initially, a symptom-free interval of eight months was achieved with prednisone therapy. However, this treatment failed after the malignant transformation had become evident.
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Castoldi, G., Scapoli, G., Grusovin, G.D. et al.: Chromosomal abnormalities in angio-immunoblastic lymphadenopathy. Ricerca Clin. Lab.6, 145 (1976)
Donhuijsen, K., Donhuijsen-Ant, R., Leder, L.D.: Evolution of angio-immunoblastic lymphadenopathy. N. Eng. J. Med.297, 840–841 (1977)
Dorfman, R.F., Warnke, R.: Lymphadenopathy simulating the malignant lymphomas. Hum. Pathol.5, 519–550 (1974)
Fisher, R.I., Jaffe, E.S., Braylan, R.C. et al.: Immunoblastic lymphadenopathy. Evolution into a malignant lymphoma with plasmacytoid features. Am. J. Med.61, 553–559 (1976)
Frizzera, G., Moran, E.M., Rappaport, H.: Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet1, 1070–1073 (1974)
Frizzera, G., Moran, E.M., Rappaport, H.: Angio-immunoblastic lymphadenopathy. Diagnosis and clinical course. Am. J. Med.59, 803–818 (1975)
Frizzera, G., Long, J.C., Berard, C.W.: Evolution of angio-immunoblastic lymphadenopathy. N. Engl. J. Med.297, 59–60 (1977)
Horne, Ch.W., Fraser, R.A., Petrie, J.C.: Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet2, 291 (1974)
Hossfeld, D.K., Höffken, K., Schmidt, C.G. et al.: Chromosome abnormalities in angio-immunoblastic lymphadenopathy. Lancet1, 198 (1976)
Howarth, C.B., Bird, C.C.: Immunoblastic sarcoma arising in child with immunoblastic lymphadenopathy. Lancet2, 747–748 (1976)
Iseman, M.D., Schwarz, M.I., Stanford, R.E.: Interstitial pneumonia in angio immunoblastic lymphadenopathy with dysproteinaemia. A case report with special histopathologic studies. Ann. Intern. Med.85, 752–755 (1976)
Kurtz, D.M.: Immunoblastic sarcoma. Am. J. Clin. Pathol.67, 227–229 (1977)
Lapes, M.J., Vivacqua, R.J., Antoniades, K.: Immunoblastic lymphadenopathy associated with phenytoin (diphenylhydantoin). Lancet1, 198 (1976)
Leder, L.D., Donhuijsen, K.: PAS-positive lymphatic cells in angio-immunoblastic lymphadenopathy. Klin. Wochenschr.56, 225–227 (1978)
Lukes, R.J., Tindle, B.H.: Immunoblastic lymphadenopathy. A hyperimmune entity resembling Hodgkin's disease. N. Engl. J. Med.292, 1–8 (1975)
Matz, L.R., Papadimitriou, J.M., Carroll, J.R. et al.: Angio-immunoblastic lymphadenopathy with dysproteinaemia. Cancer40, 2151–2160 (1977)
Moore, S.B., Harrison, E.G. Jr., Weiland, L.H.: Angio-immunoblastic lymphadenopathy. Mayo. Clin. Proc.51, 273–280 (1976)
Nathwani, B.N., Rappaport, H., Moran, E.M. et al.: Malignant lymphoma arising in angio-immunoblastic lymphadenopathy. Cancer41, 578–606 (1978)
Radaszkiewicz, T., Lennert, K.: Lymphogranulomatosis X. Klinisches Bild, Therapie und Prognose. Dtsch. Med. Wochenschr.100, 1157–1163 (1975)
Rappaport, H., Moran, E.M.: Angio-immunoblastic (immunoblastic) lymphadenopathy. N. Engl. J. Med.292, 42–43 (1975)
Rudders, R.A., Long, J.C.: Lymphadenopathy and pulmonary infiltrates in a 50-year-old man. (Case Record of the Massachusetts General Hospital No. 10-1978). N. Engl. J. Med.298, 613–620 (1978)
Schoengen, A., Feyen, H., Haferkamp, O. et al.: Immunoblastische Lymphadenopathie—maligne Neoplasie oder hyperimmunisatorische Reaktion? Klin. Wochensch.55, 265–273 (1977)
Schultz, D.R., Yunis, A.A.: Immunoblastic lymphadenopathy with mixed cryoglobulinemia. N. Engl. J. Med.292, 8–12 (1975)
Spector, J.I., Miller, S.: Immunoblastic lymphadenopathy. A report of two cases. JAMA238, 1263–1265 (1977)
Symmers, W.St.: The lymphoreticular system in systemic pathology. Symmers, W.St. (ed.), p. 702–706. Edinburgh, London, New York: Churchill Livingstone 1978
Tindle, B.H., Long, J.C.: Fever, lymphadenopathy and splenomegaly in a 60-year-old woman. (Case, Record of the Massachusetts General Hospital No. 30-1977). N. Engl. J. Med.297, 206–211 (1977)
Toth, J., Garam, T.: Immunoblastic lymphadenopathy proceeding to sarcoma. Lancet1, 102 (1977)
Twomey, J.J.: Angio-immunoblastic lymphadenopathy with dysproteinaemia. Lancet1, 1345 (1974)
Yataganas, X., Papadimitriou, C., Pangalis, G. et al.: Angio immunoblastic lymphadenopathy terminating as Hodgkin's disease. Cancer39, 2183–2189 (1977)
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Bamberg, M., Donhuijsen, K., Höher, P.G. et al. Malignant progression of angioimmunoblastic lymphadenopathy. J Cancer Res Clin Oncol 93, 255–263 (1979). https://doi.org/10.1007/BF00964581
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DOI: https://doi.org/10.1007/BF00964581