Abstract
A combination of immunodiffusion and indirect immunoautoradiographic methods revealed a group-specific (gs-) antigen (or antigens) of a D-type virus, isolated from cells of a continuous culture of human carcinomas and having a common gs-antigen with Mason-Pfizer monkey virus, in five of seven fibroadenomas of the human breast. The results indicate integration of the genome of this or a similar virus with the genome of the fibroadenoma cells. Expression of the virus genome takes place at least as far as the level of synthesis of the virus gs-antigen. The D-type virus from continuous cultures of human carcinoma cells is associated with certain forms of human tumors, one of which is fibroadenoma of the breast.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
V. M. Zhdanov, G. N. Trushinskaya, E. V. Zorin, et al., Vopr. Onkol., No. 6, 77 (1975).
V. M. Zhdanov, I. N. Kryukova, K. V. Il'in, et al., in: Viruses of Cancer and Leukemia [in Russian], Moscow (1975), pp. 8–9
K. V. Il'in, in: Problems in Autoallergy in Medical Practice [in Russian], Tallin (1975), pp. 142–143.
K. V. Il'in, A. F. Bykovskii, and V. M. Zhdanov, Vopr. Virusol., No. 4, 494 (1972).
K. V. Il'in, A. F. Bykovskii, and Zh. Zh. Spure, Byull. Éksp. Biol. Med., No. 2, 86 (1972).
K. V. Il'in, S. Oroszlan, D. Bova, et al., Vopr. Virusol., No. 1, 26 (1976).
D. A. Él'gort and G. I. Abelev, Byull. Éksp. Biol. Med., No. 2, 118 (1971).
H. C. Chopra and M. M. Mason, Cancer Res.,30, 2081 (1970).
D. Colcher, S. Spiegelman, and J. Schlom, in: Mammary Cancer in Experimental Animals and Man, Abstracts of Ninth Meeting, Pisa (1974), No. 63.
G. Geering, L. J. Old, and E. A. Boyse, J. Exp. Med.,124, 753 (1966).
R. V. Gilden and S. Oroszlan, Proc. Nat. Acad. Sci. USA,69, 1021 (1972).
K. V. Il'in (Ilyin), I. S. Irlin, A. F. Bykovskii (bykovsky), et al., Cancer (Philadelphia),34, 532 (1974).
B. S. Kim, Nature,257, 614 (1975).
E. S. Priori, K. V. Il'in (Ilyin), et al., in: International Symposium on Comparative Leukemia Research. Seventh Program and Abstracts, Copenhagen (1975), 7–9, p. 147.
D. C. Rowe, Lancet,1, 1340 (1970).
W. F. Schafer, A. Anderer, H. Bauer, et al., Virology,38, 387 (1969).
Rights and permissions
About this article
Cite this article
Il'in, K.V. Discovery of gs-antigen of D-type virus in cells of human breast fibroadenomas. Bull Exp Biol Med 82, 1549–1551 (1976). https://doi.org/10.1007/BF00799807
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00799807