Summary
The pharmacokinetics and bioavailability of suckable tablets and granules of N-acetylcysteine (NAC) have been compared after oral administration of 400 mg doses to 10 healthy volunteers. The oral bioavailability of the NAC tablets was 103%. In a multiple dosing study of the same tablets in the same subjects, a high maintenance plasma level of NAC was revealed.
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References
Sheffner AL (1963) The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent, N-acetyl-L-cysteine. Ann NY Acad Sci 106: 298–310
Sheffner AL, Medler EM, Jacobs LW, Sarett HP (1964) The in vitro reduction in viscosity of human tracheobronchial secretions by acetylcysteine. Am Rev Respir Dis 90: 721–729
Lemy-Debois N, Frigerio G, Lualdi P (1978) Oral acetylcysteine in bronchopulmonary disease, comparative clinical trial with bromhexine. Acta Therapeut 4: 125–132
Brocard H, Charpin J, Germouty J (1980) Étude multi-centrique en double aveugle avec acéthylcystéine orale vs. placébo. Eur J Respir Dis 61 [Suppl 111]: 65–69
Moldéus P, Cotgreave IA, Berggren M (1986) Lung protection by a thiol-containing antioxidant: N-Acetylcysteine. Respiration 50: 31–42
Bonanomi L, Gazzaniga A (1980) Toxicological, pharmacokinetic and metabolic studies on acetylcysteine. Eur J Respir Dis 61 [Suppl 111]: 45–51
Rodenstein D, De Coster A, Gazzaniga A (1978) Pharmacokinetics of ofal acetylcysteine: Absorption, binding and metabolism in patients with respiratory disorders. Clin Pharmacokinet 3: 247–254
Maddock J (1980) Biological properties of acetylcysteine: Assay development and pharmacokinetic studies. Eur J Respir Dis 61 [Suppl 111]: 52–58
Holdiness MR, Morgan LR, Gillen LE (1986) High-performance liquid chromatographic determination of N-acetylcysteine in human serum following acetaminophen overdosage. J Chromatogr 382: 99–106
Shumaker RC (1988) PKCALC: Program for statistical and pharmacokinetic analysis of data. Drug Metab Rev 17: 331–348
Spriet A, Beiler D (1978) Table to facilitate determination of symmetrical confidence intervals in bioavailability trials with Westlake's method. Eur J Drug Met Pharm 2: 129–132
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De Bernardi di Valserra, M., Mautone, G., Barindelli, E. et al. Bioavailability of suckable tablets of oral N-acetylcysteine in man. Eur J Clin Pharmacol 37, 419–421 (1989). https://doi.org/10.1007/BF00558514
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DOI: https://doi.org/10.1007/BF00558514