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Behavioral effects of amphetamine in a group of rhesus monkeys with lesions of dorsolateral frontal cortex

  • Animal Studies
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Abstract

Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal and frontally lesioned animals. The frontal monkeys showed a dramatic increase in hyperactivity while normal monkeys showed a variable motor response to the drug. Conspecific social interactions were disrupted by amphetamine in normal as well as lesioned animals. A functional system featuring the caudate nucleus and dorsolateral frontal cortex is presented. In addition, the possible influence of these areas on the balance of behavior modulated by limbic structures is explored. Changes in catecholamine levels are also hypothesized.

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References

  • Blum J., Chow, K., Blum, R.: Delayed response performance of monkeys with frontal removals after excitant and sedative drugs. J. Neurophysiol. 14, 197–202 (1951)

    Google Scholar 

  • Crowley, T. J., Stynes, A. J., Hydinger, M., Kaufman, I. C.: Ethanol, methamphetamine, pentobarbitol, morphine, and monkey social behavior. Arch. gen. Psychiat. 31, 829–839 (1974)

    Google Scholar 

  • Davis, G. D.: Caudate lesions and spontaneous locomotion in the monkey. Neurology (Minneap.) 8, 135–139 (1958)

    Google Scholar 

  • Devito, J. L., Smith, O. A.: Subcortical projections of the prefrontal lobe of the monkey. J. comp. Neurol. 123, 412–424 (1964)

    Google Scholar 

  • Fox, M. W.: Psychopathology in man and lower animals. J. Amer. vet. med. Ass. 159, 66–77 (1971)

    Google Scholar 

  • Ibuka, N.: The differential effect of methamphetamine upon visual exploratory behavior and spontaneous motor activity in rhesus monkeys (Macaca mulatta). Jap. Psychol. Res. 13, 26–33 (1971)

    Google Scholar 

  • Johnson, T. N., Rosvold, H. E., Mishkin, M.: Projections from behaviorally-defined sectors of the prefrontal cortex to basal ganglia, septum and diencephalon on the monkey. Exp. Neurol. 21, 20–34 (1968)

    Google Scholar 

  • Jonas, W., Scheel-Krüger, J.: Arch. inter. Pharmacodyn. 177, 379 (1969)

    Google Scholar 

  • Kievit, J., Kuypers, H. G. J. M.: Basal forebrain and hypothalamic connections to frontal and parietal cortex in the rhesus monkey. Science 187, 660–662 (1975)

    Google Scholar 

  • Kjellberg, B., Randrup, A.: Various forms of stereotyped, abnormal behavior induced by amphetamine in non-human primates. Acta physiol. scand., Suppl. 65, 330 (1969)

    Google Scholar 

  • Kjellberg, B., Randrup, A.: Stereotypy with selective stimulation of certain items of behavior observed in amphetamine-treated monkeys (Cercopitheus). Pharmakopsychiat. Neuro-Psychopharmakol 5, 1–12 (1972)

    Google Scholar 

  • Kurtsin, I. T.: Physiological mechanisms of behavior disturbances and cortico-vascular interrelations in animals. In: Abnormal behavior in animals. M. W. Fox, ed., pp. 77–106. Philadelphia, Pal: Saunders 1968

    Google Scholar 

  • Laties, V. G., Weiss, B.: Performance enhancement by the amphetamines: A new appraisal. In: Neuropsychopharmacology. H. Brill, J. O. Cole, P. Deniker, H. Hippisu, and P. B. Bradley, eds., pp. 800–808. Amsterdam: Excerpta Medica Foundation 1967

    Google Scholar 

  • Machiyama, Y., Utena, H., Kikuchi, M.: Behavioral disorders in Japanese monkeys produced by the long-term administration of methamphetamine. Proc. Japan Acad. 46, 738–743 (1970)

    Google Scholar 

  • Miller, M. H.: Dorsolateral frontal lobe lesions and behavior in the macaque: Dissociation of threat and aggression. Accepted for publication Physiology and Behavior 1975

  • Pandya, D. N., Kuypers, H. G. J. M.: Cortico-cortical connections in the rhesus monkey. Brain Res. 13, 13–36 (1969)

    Google Scholar 

  • Randrup, A., Munkvad, I.: Influence of amphetamines on animal behavior. Stereotypy, functional impairment and possible animal-human correlation. Psychiat. Neurol. Neurochir. 75, 193–202 (1972)

    Google Scholar 

  • Van Rossum, J. M.: Psychopharmacology of amphetamines. Psychiat. Neurol. Neurochir. (Amst.) 75, 165–178 (1972)

    Google Scholar 

  • Wallach, M. B.: Drug induced stereotyped behavior: Similarities and differences. In: Neuropsychopharmacology of monoamines and their regulatory enzymes. E. Usdin, ed., pp. 241–260. New York: Raven Press 1974

    Google Scholar 

  • Weiss, B., Laties, V. G.: Enhancement of human performance by caffeine and the amphetamines. Pharmacol. Rev. 14, 1–36 (1962)

    Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, College of Medicine and Dentistry of New Jersey-Rutgers Medical School, 08854, Piscataway, New Jersey, U.S.A.

    Michael H. Miller

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  1. Michael H. Miller
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Miller, M.H. Behavioral effects of amphetamine in a group of rhesus monkeys with lesions of dorsolateral frontal cortex. Psychopharmacology 47, 71–74 (1976). https://doi.org/10.1007/BF00428704

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  • DOI: https://doi.org/10.1007/BF00428704

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