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Excretion of (sulfated) steroids in the urine and excretion of cholesterol sulfate in the feces of boys with recessive X-linked ichthyosis

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Summary

The excretion of sulfated steroids was investigated in the urine and feces of six boys aged 9 months to 7 years and 10 months who had recessive X-linked ichthyosis. Profiles of urinary total steroids as well as sulfated steroids were normal. Cholesterol sulfate excretion in the urine was not elevated. In the feces 2–20% of total cholesterol was cholesterol sulfate, whereas in the feces of 28 healthy children no cholesterol sulfate was demonstrable. In the 6 patients total cholesterol excretion (500–2,500 μmol/kg feces) was also elevated in comparison with the 28 healthy controls (150–700 μmol/kg feces, mean 365 μmol/kg feces)

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Authors and Affiliations

  1. Department of Neonatology (AM), University of Amsterdam, Academisch Medisch Centrum, Amsterdam, The Netherlandss

    A. Marinkovic-Ilsen

  2. Department of Clinical Biochemistry (AE), Slotervaart Ziekenhuis, Amsterdam, The Netherlandss

    A. van den Ende

  3. Central Laboratory for Clinical Chemistry (BGW), University Hospital, Groningen, The Netherlandss

    B. G. Wolthers

Authors
  1. A. Marinkovic-Ilsen
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  2. A. van den Ende
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  3. B. G. Wolthers
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Marinkovic-Ilsen, A., van den Ende, A. & Wolthers, B.G. Excretion of (sulfated) steroids in the urine and excretion of cholesterol sulfate in the feces of boys with recessive X-linked ichthyosis. Arch Dermatol Res 276, 364–369 (1984). https://doi.org/10.1007/BF00413356

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  • DOI: https://doi.org/10.1007/BF00413356

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