Abstract
Male Wistar rats were treated orally with D-l-amphetamine sulphate in a dose of 3 mg/kg daily during 9 months. An increase of locomotor activity during the first 3 months was observed, while in the following 6 months locomotor activity was similar to the control group. The estimations of noradrenaline and 5-hydroxytryptamine levels in 9 discrete areas of brain, after 9 months of amphetamine treatment showed no changes in 5-HT level, but a significant decrease of the noradrenaline level in the pons. Withdrawal of amphetamine from rats treated for 9 months with this drug caused an inhibition of locomotor activity and a decrease of noradrenaline and 5-hydroxytryptamine level in the cerebellum.
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Herman, Z.S., Trzeciak, H., Chruściel, T.L. et al. The influence of prolonged amphetamine treatment and amphetamine withdrawal on brain biogenic amine content and behaviour in the rat. Psychopharmacologia 21, 74–81 (1971). https://doi.org/10.1007/BF00403998
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DOI: https://doi.org/10.1007/BF00403998