Skeletal Radiology

, Volume 16, Issue 2, pp 91–97

The spectrum of skeletal changes associated with long-term administration of 13-cis-retinoic acid

  • Jack P. Lawson
  • Joseph McGuire

DOI: 10.1007/BF00367754

Cite this article as:
Lawson, J.P. & McGuire, J. Skeletal Radiol (1987) 16: 91. doi:10.1007/BF00367754


The roentgenographic changes noted in 13 patients, who had been treated with long-term 13-cis-retinoic acid for inherited scaling disorders, are presented. These patients were aged 13–16 years and had received this therapy for 16–87 months (mean, 58 months). The most pronounced abnormality was osteophyte formation, particularly in the cervical spine. Other changes which were noted included ossification of the anterior longitudinal and atlanto-occipital ligaments, proliferative enthesopathies, diminished bone density, premature fusion of epiphyses, and modeling abnormalities. Six of the 13 patients were asymptomatic and the osseous manifestations of this therapy were identified only by roentgenographic evaluation.

Key words

Retinoid therapyOsteophytosisAnterior longitudinal ligament ossificationProliferative enthesopathyPremature fusion of epiphysesOsteopeniaVitamin A toxicityRetinoid toxicity

Copyright information

© International Skeletal Society 1987

Authors and Affiliations

  • Jack P. Lawson
    • 1
  • Joseph McGuire
    • 2
  1. 1.Department of Diagnostic RadiologyYale University School of MedicineNew HavenUSA
  2. 2.Department of DermatologyYale University School of MedicineNew HavenUSA