Colorectal cancer and solar radiation
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
It has been suggested that sunlight might have a role in the prevention of colorectal cancer via a mechanism involving vitamin D. We used data from nine population-based cancer registries in the United States to analyze incidence rates for colon and rectal cancer during 1973–84 as a function of regional variation in the levels of available solar radiation. Data were restricted to include only those persons born and diagnosed in the same state. Incidence rates of colon and rectal cancer among men tended to increase with decreasing levels of solar radiation. Compared to rates in New Mexico and Utah, for example, rates in the Detroit area (MI), Connecticut, and western Washington were 50 percent to 80 percent higher. Among women, colon cancer rates showed a similar trend, though of smaller magnitude; rates of rectal cancer among women did not vary in relation to levels of available solar radiation.
- Zaridze DG. Environmental etiology of large-bowel cancer. JNCI 1983; 70: 389–400.
- Garland CF, Garland FC. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int J Epidemiol 1980; 9: 227–31.
- Gorham ED, Garland CF, Garland FC. Acid haze air pollution and breast and colon cancer mortality in 20 Canadian cities. Can J Public Health 1989; 80: 96–100.
- Garland CF, Garland FC, Shaw EK, Comstock GW, Helsing KJ, Gorham ED. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study. Lancet 1989; ii: 1176–8.
- Garland C, Shekelle RB, Barrett-Connor E, Criqui MH, Rossof AH, Paul O. Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 1985; i: 307–9.
- Young JL Jr, Percy CL, Asire AJ, eds. Surveillance, Epidemiology, and End Results Program: incidence and mortality data, 1973–1977. NCI Monogr 1981; 57: 1–1082.
- World Health Organization, International Classification of Diseases for Oncology. Geneva, Switzerland: WHO, 1976.
- US Bureau of the Census. Census of Population, 1980 Detailed Population Characteristics. Washington, DC: GPO, 1983; PCD80–1-D.
- Knapp CL, Stoffel TL, Whitaker SD. Insolation Data Manual. Golden, CO: Solar Energy Research Institute, October 1980; SERI/SP-75-789.
- Emerson SS, Emerson JC. Direct standardization of incidence rates in the presence of incomplete data. Western North American Region of the International Biomeytric Society, Annual meeting, Bozeman, MT, June 1990.
- Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol. II. The Design and Analysis of Cohort Studies. Lyon, France: International Agency for Research on Cancer, 1987; IARC Sci. Pub. No. 82.
- Kleinbaum DG, Kupper LL. Applied Regression Analysis and Other Multivariable Methods. Boston, MA: Duxbury Press, 1978.
- Spitz MR, Paolucci MJ, Newell GR. Occurrence of colo-rectal cancer: focus on Texas. Cancer Bull 1988; 40: 187–91.
- Percy C, Stanek E, Gloeckler L. Accuracy of cancer death certificates and its effect on cancer mortality statistics. Am J Public Health 1982; 71: 242–50.
- Morgenstern H. Uses of ecologic analyses in epidemiologic research. Am J Public Health 1982; 72: 1336–44.
- Holick MF, MacLaughlin JA, Clark MB, Holick SA, Potts JT. Photosynthesis of previtamin D3 in human skin and the physiologic consequences. Science 1980; 210: 203–5.
- Wargovich MJ, Eng VWS, Newmark HL, Bruce WR. Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Carcinogenesis 1983; 4: 1205–7.
- Buset M, Lipkin M, Winawer S, Swaroop S, Friedman E. Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res 1986; 46: 5426–30.
- Wargovich MJ, Lointier PH. Calcium and vitamin D modulate mouse colon epithelial proliferation and growth characteristics of a human colon tumor cell line. Can J Physiol Pharmacol 1987; 65: 472–7.
- Lipkin M, Friedman E, Winawer SJ, Newmark H. Colonic epithelial cell proliferation in responders and nonresponders to supplemental dietary calcium. Cancer Res 1989; 49: 248–54.
- Lipkin M, Nemark H. Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. N Engl J Med 1985; 313: 1381–4.
- Manolagas SC. Vitamin D and its relevance to cancer. Anticancer Res 1987; 7: 625–38.
- Lointer P, Wargovich MJ, Saez S, Levin B, Wildríck DM, Boman BM. The role of vitamin D3 in the proliferation of a human colon cancer cell line in vitro. Anticancer Res 1987; 7: 817–22.
- Eisman JA, Barkla DH, Tutton PJM. Suppression of in vivo growth of human cancer solid tumor xenografts by 1,25-dihydroxyvitamin D3. Cancer Res 1987; 47: 21–5.
- Garland CE, Garland FC, Gorham ED. Can colon cancer incidence and death rates be reduced with calcium and vitamin D? Am J Clin Nutr 1991; 54: 193S-201S.
- Haddad JG, Hahn TJ. Natural and synthetic sources of circulating 25-hydroxyvitamin D in man. Nature 1973; 244: 515–7.
- MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest 1985; 76: 1536–8.
- Colorectal cancer and solar radiation
Cancer Causes & Control
Volume 3, Issue 1 , pp 95-99
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers
- Additional Links
- Colorectal neoplasms
- United States
- Industry Sectors