Skip to main content

Advertisement

Log in

Potential role of repetitive transcranial magnetic stimulation in obesity

  • Brief Report
  • Published:
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity Aims and scope Submit manuscript

Abstract

Background

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique with mild side effects. Some forms of obesity may arise from eating disorders and recent data suggest that rTMS treatment could have beneficial effects in eating disorders.

Purpose

The purpose of this comprehensive review is to hypothesize that rTMS may play a role in obesity.

Materials and methods

Articles were selected based on a search on medline using the terms “rTMS”, “food craving”, “eating disorders”, “addiction”, and “obesity”. They were published between 1995 and 2013.

Results

Repetitive transcranial magnetic stimulation has been evaluated in the treatment of bulimia nervosa. It appears that it exerts its effect via the reduction of the level of craving for food. Obesity is being recognized as one of the endpoints of food addiction and craving. Besides, rTMS and transcranial direct current stimulation are brain stimulation techniques being used in the treatment of psychoactive substance addiction.

Conclusions

Repetitive transcranial magnetic stimulation, through the reduction of food craving may be a potential treatment for a subset of individuals suffering from obesity. Further studies with a higher number of subjects are still needed to confirm the effects of rTMS on obesity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Mishra BR, Sarkar S, Praharaj SK et al (2011) Repetitive transcranial magnetic stimulation in psychiatry. Ann Indian Acad Neurol 14(4):245–251

    Article  PubMed Central  PubMed  Google Scholar 

  2. Fitzgerald PB, Brown TL, Marston NAU et al (2003) Transcranial magnetic stimulation in the treatment of depression. Arch Gen Psychiatry 60:1002–1008

    Article  PubMed  Google Scholar 

  3. Tsai SJ (2005) Repetitive transcranial magnetic stimulation: a possible novel therapeutic approach to eating disorders. Med Hypotheses 65:1176–1178

    Article  PubMed  Google Scholar 

  4. Ahn HM, Kim SE, Kim SH (2013) The effects of high-frequency rTMS over the left dorsolateral prefrontal cortex on reward responsiveness. Brain Stimul 6(3):310–314

    Article  PubMed  Google Scholar 

  5. Volkow N, Wang G, Tomasi D, Baler R (2013) The addictive dimensionality of obesity. Biol Psychiatry 73(9):811–818

    Article  PubMed  Google Scholar 

  6. Volkow N, Wang G, Fowler J et al (2008) Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology. Philos Trans R Soc Lond B Biol Sci 363(1507):3191–3200

    Article  PubMed Central  PubMed  Google Scholar 

  7. Pedram P, Wadden D, Amini P et al (2013) Food addiction: its prevalence and significant association with obesity in the general population. PLoS One 8(9):e74832

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Gold MS, Byars JA, Frost-Pineda K (2004) Occupational exposure and addictions for physicians: case studies and theoretical implications. Psychiatr Clin North Am 27:745–753

    Article  PubMed  Google Scholar 

  9. Warren MW, Gold MS (2007) The relationship between obesity and drug use. Am J Psychiatry 164:1268–1269

    Article  PubMed  Google Scholar 

  10. Kenny PJ, Voren G, Johnson PM (2013) Dopamine D2 receptors and striatopallidal transmission in addiction and obesity. Curr Opin Neurobiol 23(4):535–538

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Salamone JD, Cousins MS, Snyder BJ (1997) Behavioral functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis. Neurosci Biobehav Rev 21:341–359

    Article  CAS  PubMed  Google Scholar 

  12. Von Deneen KM, Liu Y (2011) Obesity as an addiction: why do the obese eat more? Maturitas 68:342–345

    Article  Google Scholar 

  13. Scharmuller W, Ubel S, Ebner F, Schienle A (2012) Appetite regulation during food cue exposure: a comparison of normal-weight and obese women. Neurosci Lett 518(2):106–110

    Article  PubMed  Google Scholar 

  14. Filbey FM, Myers US, Dewitt S (2012) Reward circuit function in high BMI individuals with compulsive overeating: similarities with addiction. Neuroimage 63(4):1800–1806

    Article  PubMed  Google Scholar 

  15. Svetlak M, Psenicova K (2012) Food craving symptoms in older school age children and its relation to body-mass index. Vnitr Lek 58(2):110–117

    CAS  PubMed  Google Scholar 

  16. Avena NM, Rada P, Hoebel BG (2008) Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev 32:20–39

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Wurtman RJ, Wurtman JJ (1995) Brain serotonin, carbohydrate-craving, obesity and depression. Obes Res 3:477S–480S

    Article  PubMed  Google Scholar 

  18. Berthoud HR, Lenard NR, Shin AC (2011) Food reward, hyperphagia, and obesity. Am J Physiol Regul Integr Comp Physiol 300(6):R1266–R1277

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Hausmann A, Mangweth B, Walpoth M et al (2004) Repetitive transcranial magnetic stimulation (rTMS) in the double-blind treatment of a depressed patient suffering from bulimia nervosa: a case report. Int J Neuropsychopharmacol 7:371–373

    Article  PubMed  Google Scholar 

  20. Van den Eynde F, Claudino AM, Mogg A et al (2010) Repetitive transcranial magnetic stimulation reduces cue-induced food craving in bulimic disorders. Biol Psychiatry 67:793–795

    Article  PubMed  Google Scholar 

  21. Walpoth M, Hoertnagl C, Mangweth-Matzek B et al (2008) Repetitive transcranial magnetic stimulation in bulimia nervosa: preliminary results of a single-centre, randomised, double-blind, sham-controlled trial in female outpatients. Psychother Psychosom 77:57–60

    Article  CAS  PubMed  Google Scholar 

  22. Van den Eynde F, Broadbent H, Guillaume S et al (2012) Handedness, repetitive transcranial magnetic stimulation and bulimic disorders. Eur Psychiatry 27(4):290–293

    Article  PubMed  Google Scholar 

  23. Claudino AM, Van den Eynde F, Stahl D et al (2011) Repetitive transcranial magnetic stimulation reduces cortisol concentrations in bulimic disorders. Psychol Med 41(6):1329–1336

    Article  CAS  PubMed  Google Scholar 

  24. Uher R, Yoganathan D, Mogg A et al (2005) Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving. Biol Psychiatry 58:840–842

    Article  PubMed  Google Scholar 

  25. Barth KS, Rydin-Gray S, Kose S et al (2011) Food cravings and the effects of left prefrontal repetitive transcranial magnetic stimulation using an improved sham condition. Front Psychiatry 2:9

    PubMed Central  PubMed  Google Scholar 

  26. Feil J, Zangen A (2010) Brain stimulation in the study and treatment of addiction. Neurosci Biobehav Rev 34:559–574

    Article  PubMed  Google Scholar 

  27. Wing VC, Barr MS, Wass CE et al (2013) Brain stimulation methods to treat tobacco addiction. Brain Stimul 6(3):221–230

    Article  PubMed  Google Scholar 

  28. De Ridder D, Vanneste S, Kovacs S et al (2011) Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study. Neurosci Lett 496(1):5–10

    Article  PubMed  Google Scholar 

  29. Barr MS, Farzan F, Wing VC et al (2011) Repetitive transcranial magnetic stimulation and drug addiction. Int Rev Psychiatry 23(5):454–466

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rami Bou Khalil.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bou Khalil, R., El Hachem, C. Potential role of repetitive transcranial magnetic stimulation in obesity. Eat Weight Disord 19, 403–407 (2014). https://doi.org/10.1007/s40519-013-0088-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40519-013-0088-x

Keywords

Navigation