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Etanercept: A Review of Its Use in Autoimmune Inflammatory Diseases

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Abstract

With its approval more than 15 years ago, subcutaneous etanercept (Enbrel®) was the first biological disease-modifying antirheumatic drug (bDMARD) and the first tumour necrosis factor inhibitor to be approved for use in rheumatic diseases. Etanercept remains an important cost-effective treatment option in adult patients with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis or plaque psoriasis, and in paediatric patients with juvenile idiopathic arthritis or plaque psoriasis. In all of these populations, etanercept (with or without methotrexate) effectively reduced signs and symptoms, disease activity and disability, and improved health-related quality of life, with these benefits sustained during long-term treatment. The safety profile of etanercept during short- and long-term treatment was consistent with the approved product labelling, with adverse events being of a predictable and manageable nature. The introduction of etanercept and other bDMARDs as therapeutic options for patients with autoimmune rheumatic diseases and spondyloarthropathies revolutionized disease management and these agents continue to have a central role in treatment strategies. This article reviews the extensive clinical experience with etanercept in these patient populations.

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Disclosure

The preparation of this review was not supported by any external funding. During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on this article. Changes resulting from comments received were made by the author on the basis of scientific and editorial merit. Lesley Scott is a salaried employee of Adis/Springer.

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The manuscript was reviewed by: R. Alten, Schlosspark-Klinik, Charite-University Medicine Berlin, Internal Medicine II, Rheumatology, Clinical Immunology, Berlin, Germany; S. Appenzeller, State University of Campinas CEP, Department of Medicine, Sao Paulo, Brazil; M. Bergman, Drexel University College of Medicine, Division of Rheumatology, Department of Medicine, Philadelphia, PA, USA; R. Cimaz, University of Florence, Anna Meyer Children’s Hospital, Florence, Italy; M.J. Puszczewicz, University of Medical Sciences, Department of Rheumatology and Internal Medicine, Poznań, Poland.

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Scott, L.J. Etanercept: A Review of Its Use in Autoimmune Inflammatory Diseases. Drugs 74, 1379–1410 (2014). https://doi.org/10.1007/s40265-014-0258-9

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