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Orale Toleranz bei der Maus als Lehrstück für orale Immuntherapie beim Menschen?

Oral tolerance in mice as a model of human immunotherapy?

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Zusammenfassung

Im Mausmodell bewirkt die orale Gabe von Antigen eine systemische Immunsuppression, die als orale Toleranz bezeichnet wird. Die Prozesse, die der Entstehung und Aufrechterhaltung der oralen Toleranz zugrunde liegen, sind in ihren Grundzügen verstanden. Eine Schlüsselrolle spielen hierbei durch die Antigengabe induzierte regulatorische T-Zellen. Derzeit ist unklar, inwieweit Nahrungsmittelallergien als ein Versagen vergleichbarer Prozesse beim Menschen aufgefasst werden dürfen und inwiefern durch orale Immuntherapien bewirkte Prozesse der oralen Toleranzinduktion im Tiermodell ähneln.

Summary

In mice, uptake of antigen via the oral route induces a systemic immunosuppression, known as oral tolerance. The main features of oral tolerance induction are mechanistically well understood and we know that induced regulatory T cells play a key role. Yet, at present it is unclear to what extent human food allergy shall be considered as failure of oral tolerance induction and if oral immunotherapy in humans triggers comparable immunosuppressive pathways.

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Abb. 1

Abbreviations

DC:

Dendritische Zellen

IgE:

Immunglobulin E

iTreg:

Induzierte regulatorische T-Zellen

MadCAM-1:

Mucosal addressin cell adhesion molecule-1

mLN:

Mesenterische Lymphknoten

nTreg:

Natürliche regulatorische T-Zellen

TCR:

T-Zell-Rezeptor

Treg:

Regulatorische T-Zellen

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Authors and Affiliations

  1. Institut für Immunologie, Medizinische Hochschule Hannover, Hannover, Deutschland

    Oliver Pabst

  2. Institut für Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Oliver Pabst

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  1. Oliver Pabst
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Correspondence to Oliver Pabst.

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Der Autor erklärt, dass kein Interessenkonflikt besteht.

*You can find an authorised Englisch version of this article online at http://link.springer.com

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Pabst, O. Orale Toleranz bei der Maus als Lehrstück für orale Immuntherapie beim Menschen?. Allergo J 22, 312–316 (2013). https://doi.org/10.1007/s15007-013-0221-1

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  • DOI: https://doi.org/10.1007/s15007-013-0221-1

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