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Novel 2,2′-bipyridine palladium(II) complexes with glycine derivatives: synthesis, characterization, cytotoxic assays and DNA-binding studies

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Abstract

The two water-soluble designed palladium(II) complexes, [Pd(bpy)(pip-Ac)]NO3 and [Pd(bpy)(mor-Ac)]NO3, (where bpy is 2,2′-bipyridine, pip-Ac is 1-piperidineacetato and mor-Ac is 4-morpholineacetato) have been synthesized and characterized by elemental analyses, molar conductivity measurements and spectroscopic methods (FT-IR, 1H NMR, UV–Vis). The complexes have been tested for in vitro cytotoxic activity against human breast cancer cell line, T47D. The binding of these complexes with DNA has been investigated by absorption spectroscopy, fluorescence titration spectra, EB displacement and gel chromatography. The results suggest that the complexes can bind to DNA cooperatively through a static mechanism at low concentrations (~0.57 μM). The thermodynamic parameters indicated that the van der Waals and hydrogen binding might play a major role in the interaction of these complexes with DNA.

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Acknowledgments

We are grateful for the financial support of the Materials and Energy Research Center, the University of Sistan and Baluchestan and of the University of Tehran.

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Authors and Affiliations

  1. Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran

    Maryam Saeidifar

  2. Department of Chemistry, University of Sistan and Baluchestan, Zahedan, Iran

    Hassan Mansouri-Torshizi

  3. Department of Biological Sciences, Tarbiat Moallem University, Tehran, Iran

    Adele Divsalar

  4. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

    Ali Akbar Saboury

Authors
  1. Maryam Saeidifar
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  2. Hassan Mansouri-Torshizi
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  3. Adele Divsalar
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Correspondence to Maryam Saeidifar.

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Saeidifar, M., Mansouri-Torshizi, H., Divsalar, A. et al. Novel 2,2′-bipyridine palladium(II) complexes with glycine derivatives: synthesis, characterization, cytotoxic assays and DNA-binding studies. J IRAN CHEM SOC 10, 1001–1011 (2013). https://doi.org/10.1007/s13738-013-0237-1

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