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Designer foods and their benefits: A review

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Abstract

Designer foods are normal foods fortified with health promoting ingredients. These foods are similar in appearance to normal foods and are consumed regularly as a part of diet. In this article we have reviewed the global regulatory status and benefits of available designer foods such as designer egg, designer milk, designer grains, probiotics, designer foods enriched with micro and macronutrients and designer proteins. Designer foods are produced by the process of fortification or nutrification. With the advances in the biotechnology, biofortification of foods using technologies such as recombinant DNA technology and fermentation procedures are gaining advantage in the industry. The ultimate acceptability and extensive use of designer foods depend on proper regulation in the market by the regulatory authorities of the country and by creating consumer awareness about their health benefits through various nationwide programs.

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References

  • Abdel-Nour N, Ngadi M (2011) Detection of omega-3 fatty acid in designer eggs using hyperspectral imaging. Int J Food Sci Nutr 62(4):418–422, Epub 2011 Mar 23

    Article  CAS  Google Scholar 

  • Abdollahi Z, Elmadfa I, Djazayeri A, Sadeghian S, Freisling H, Mazandarani FS, Mohamed K (2008) Folate, vitamin B12 and homocysteine status in women of childbearing age: baseline data of folic acid wheat flour fortification in Iran. Ann Nutr Metab 53(2):143–150

    Article  CAS  Google Scholar 

  • Abdulah R, Faried A, Kobayashi K, Yamazaki C, Suradji EW, Ito K, Suzuki K, Murakami M, Kuwano H, Koyama H (2009) Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. BMC Cancer 9:414–425

    Article  CAS  Google Scholar 

  • Achón M, Arrate A, Alonso-Aperte E, Varela-Moreiras G (2011) Plasma folate concentrations after a single dose ingestion of whole and skimmed folic acid fortified milks in healthy subjects. Eur J Nutr 50(2):119–125, Epub 2010 Jun 26

    Article  CAS  Google Scholar 

  • al-Hooti SN, Sidhu JS, al-Saqer JM, al-Othman A (2002) Effect of raw wheat germ addition on the physical texture and objective color of a designer food (pan bread). Nahrung 46(2):68–72

    Article  CAS  Google Scholar 

  • Allen LH, Peerson JM (2009) Maternal Micronutrient Supplementation Study Group. Impact of multiple micronutrient versus iron-folic acid supplements on maternal anemia and micronutrient status in pregnancy. Food Nutr Bull 30(4 Suppl):S527–S532

    Google Scholar 

  • Aller R, De Luis DA, Izaola O, Conde R, Gonzalez Sagrado M, Primo D, De La Fuente B, Gonzalez J (2011) Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial. Eur Rev Med Pharmacol Sci 15(9):1090–1095

    CAS  Google Scholar 

  • Anderson RA, Bryden NA, Planski MM, Richards MP (1989) Chromium supplementation of turkeys: Effects on tissue chromium. J Agric Food Chem 37:131–134

    Article  CAS  Google Scholar 

  • Angeles-Agdeppa I, Capanzana MV, Li-Yu J, Schollum LM, Kruger MC (2010) High-calcium milk prevents overweight and obesity among postmenopausal women. Food Nutr Bull 31(3):381–390

    Google Scholar 

  • Anon (2010) USFDA Center for Food Safety and Applied Nutrition http://www.cfsan.fda.gov/list.html. Accessed on 22 December 2011

  • Arai S (1996) Studies on functional foods in Japan. Bioscie Biotechnol Biochemi 60:9–15

    Article  CAS  Google Scholar 

  • Arslanoglu S, Moro GE, Ziegler EE (2010) Optimization of human milk fortification for preterm infants: new concepts and recommendations. J Perinat Med 38(3):233–238

    Article  CAS  Google Scholar 

  • Arslanoglu S, Moro GE, Ziegler EE (2009) Preterm infants fed fortified human milk receive less protein than they need. J Perinatol 29(7):489–492, Epub 2009 May 14

    Article  CAS  Google Scholar 

  • Asemi Z, Samimi M, Tabasi Z, Talebian P, Azarbad Z, Hydarzadeh Z, Esmaillzadeh A (2011) Effect of daily consumption of probiotic yoghurt on lipid profiles in pregnant women: a randomized controlled clinical trial. J Matern Fetal Neonatal Med 1–5 Ahead of Print.

  • Atalah SE, Araya BM, Rosselot PG, Araya LH, Vera AG, Andreu RR, Barba GC, Rodriguez L (2009) Consumption of a DHA-enriched milk drink by pregnant and lactating women, on the fatty acid composition of red blood cells, breast milk, and in the newborn]. Arch Latinoam Nutr 59(3):271–277

    Google Scholar 

  • Axten LG, Wohlers MW, Wegrzyn T (2008) Using phytochemicals to enhance health benefits of milk: impact of polyphenols on flavor profile. J Food Sci 73(6):H122–H126

    Article  CAS  Google Scholar 

  • Beale AM, Fasulo DA, Craigmill AL (1990) Effects of oral and parenteral selenium supplements on residues in meat, milk and eggs. Rev Environ Contam Toxicol 115:125–150

    Article  CAS  Google Scholar 

  • Bennett DC, Cheng KM (2010) Selenium enrichment of table eggs. Poult Sci 89(10):2166–2172

    Article  CAS  Google Scholar 

  • Bonjour JP, Benoit V, Pourchaire O, Ferry M, Rousseau B, Souberbielle JC (2009) Inhibition of markers of bone resorption by consumption of vitamin D and calcium-fortified soft plain cheese by institutionalised elderly women. Br J Nutr 102(7):962–966, Epub 2009 May 18

    Article  CAS  Google Scholar 

  • Bourre JM, Galea F (2006) An important source of omega-3 fatty acids, vitamins D and E, carotenoids, iodine and selenium: a new natural multi-enriched egg. J Nutr Health Aging 10(5):371–376

    CAS  Google Scholar 

  • Brophy B, Smolenski G, Wheeler T, Wells D, L’Huillier P, Laible G (2003) Cloned transgenic cattle produce milk with higher levels of beta-casein and kappa-casein. Nat Biotechnol 21(2):157–162

    Article  CAS  Google Scholar 

  • Cantor AH, Scott ML (1974) The effect of selenium in the hen’s diet on egg production, hatchability, performance of progeny and selenium concentrations in eggs. Poultry Sci 53(5):1870–1880

    Article  CAS  Google Scholar 

  • Caston L, Leeson S (1990) Research note: Dietary flaxseed and egg composition. Poultry Sci 69:1617–1620

    Article  Google Scholar 

  • Cerrato PL (1999) Using designer margarines to control lipid levels. Registered Nurse 62(10):67–68

    CAS  Google Scholar 

  • Chandra Mohan KV, Devaraj H, Prathiba D, Hara Y, Nagini S (2006) Antiproliferative and apoptosis inducing effect of lactoferrin and black tea polyphenol combination on hamster buccal pouch carcinogenesis. Biochim Biophys Acta 1760(10):1536–1544

    Article  CAS  Google Scholar 

  • Chandra Mohan KV, Hara Y, Abraham SK, Nagini S (2005) Comparative evaluation of the chemopreventive efficacy of green and black tea polyphenols in the hamster buccal pouch carcinogenesis model. Clin Biochem 38(10):879–886

    Article  CAS  Google Scholar 

  • Chang SK (2001) Biotechnology–updates and new developments. Biomed Environ Sci 14(1–2):32–39

    CAS  Google Scholar 

  • Chow J, Klein EY, Laxminarayan R (2010) Cost-effectiveness of “golden mustard” for treating vitamin A deficiency in India. PLoS One 5(8):e12046. doi:10.1371/journal.pone.0012046, 10

    Article  CAS  Google Scholar 

  • Clifton PM, Noakes M, Sullivan D, Erichsen N, Ross D, Annison G, Fassoulakis A, Cehun M, Nestel P (2004) Cholesterol-lowering effects of plant sterol esters differ in milk, yoghurt, bread and cereal. Eur J Clin Nutr 58(3):503–509

    Article  CAS  Google Scholar 

  • Cook; Mark E. (Madison, WI), Aydin; Rahim (Madison, WI), Pariza; Michael W. (Madison, WI). Eggs enriched with conjugated linoleic acid. United States Patent, Appl. No.:09/060, 588

  • Corcoran BM, Stanton C, Fitzgerald G, Ross RP (2008) Life under stress: the probiotic stress response and how it may be manipulated. Curr Pharm Des 14(14):1382–99

    Article  CAS  Google Scholar 

  • Cramer JM, Teran-Garcia M, Jeffery EH (2011) Enhancing sulforaphane absorption and excretion in healthy men through the combined consumption of fresh broccoli sprouts and a glucoraphanin-rich powder. Br J Nutr 13:1–6 [Epub ahead of print]

    Google Scholar 

  • Cruickshank EM (1934) Studies in fat metabolism in fowl. I. Composition of egg fat and depot fat of thr fowl as affected by the ingestion of large amount of different fats. Biochem J 28:965–977

    CAS  Google Scholar 

  • Damianaki A, Bakogeorgou E, Kampa M, Notas G, Hatzoglou A, Panagiotou S, Gemetzi C, Kouroumalis E, Martin PM, Castanas E (2000) Potent inhibitory action of red wine polyphenols on human breast cancer cells. J Cell Biochem 78(3):429–441

    Article  CAS  Google Scholar 

  • Dennehy C (2011) Omega-3 fatty acids and ginger in maternal health: Pharmacology, Efficacy and Safety. J Midwifery & Women’s Health 56(6):584–590

    Article  Google Scholar 

  • De-Regil LM, Suchdev PS, Vist GE, Walleser S, Peña-Rosas JP (2011) Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database of Systematic Reviews 9:CD008959. doi:10.1002/14651858.CD008959.pub2

    Google Scholar 

  • Di Natale C, Coclite E, Di Ventura L, Di Fabio S (2011) Fortification of maternal milk for preterm infants. J Matern Fetal Neonatal Med 1:41–43, Epub 2011 Sep 2

    Article  Google Scholar 

  • Doucet A, Williams M, Gagnon MC, Sasseville M, Beauregard M (2002) Engineering nutritious proteins: improvement of stability in the designer protein MB-1 via introduction of disulfide bridges. J Agric Food Chem 50(1):92–98

    Article  CAS  Google Scholar 

  • EFSA (2002) http://www.efsa.europa.eu. Accessed on 22 December 2011

  • Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V (2011) Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Nutrition. doi:10.1016/j.nut.2011.08.013

  • Elson CO (2006) From cheese to pharma: a designer probiotic for IBD. Clin Gastroenterol Hepatol 4(7):836–867

    Article  Google Scholar 

  • Escurriol V, Cofán M, Serra M, Bulló M, Basora J, Salas-Salvadó J, Corella D, Zazpe I, Martínez-González MA, Ruiz-Gutiérrez V, Estruch R, Ros E (2009) Serum sterol responses to increasing plant sterol intake from natural foods in the Mediterranean diet. Eur J Nutr 48(6):373–82

    Article  CAS  Google Scholar 

  • Eshigina S, Gapparov MM, Mal’tsev GIu, Kulakov SN (2007) Influence of dietary therapy containing sunflower oil fortified with phospholipids on the lipid metabolism in patients with hypertension and obesity. Vopr Pitan 76(1):58–62

    CAS  Google Scholar 

  • Estrada JD, Boeneke C, Bechtel P, Sathivel S (2011) Developing a strawberry yogurt fortified with marine fish oil. J Dairy Sci 94(12):5760–5769

    Article  CAS  Google Scholar 

  • Fabian E, Majchrzak D, Dieminger B, Meyer E, Elmadfa I (2008) Influence of probiotic and conventional yoghurt on the status of vitamins B1, B2 and B6 in young healthy women. Ann Nutr Metab 52(1):29–36, Epub 2008 Jan 30

    Article  CAS  Google Scholar 

  • Fisinin VI, Papazyan TT, Surai PF (2009) Producing selenium-enriched eggs and meat to improve the selenium status of the general population. Crit Rev Biotechnol 29(1):18–28

    Article  CAS  Google Scholar 

  • Flynn A, Moreiras O, Stehle P, Fletcher RJ, Müller DJ, Rolland V (2003) Vitamins and minerals: a model for safe addition to foods. Eur J Nutr 42(2):118–130

    Article  CAS  Google Scholar 

  • Fortier ME, Audet I, Giguère A, Laforest JP, Bilodeau JF, Quesnel H, Matte JJ (2012) Effect of dietary organic and inorganic selenium on antioxidant status, embryo development and reproductive performance in hyperovulatory first-parity gilts. J Anim Sci 90(1):231–40

    Article  CAS  Google Scholar 

  • Friedrich MJ (1999) Genetically enhanced rice to help fight malnutrition. J Am Med Assoc 282(16):1508–1509

    Article  CAS  Google Scholar 

  • FSSAI (2006).Food Safety Satandards Authority of India, New Delhi, India. http://www.fssai.gov.in Accessed on 22 December 2011

  • Gagnon MC, Williams M, Doucet A, Beauregard M (2000) Replacement of tyr62 by trp in the designer protein milk bundle-1 results in significant improvement of conformational stability. FEBS Lett 484(2):144–148

    Article  CAS  Google Scholar 

  • Gale CR, Marriott LD, Martyn CN, Limond J, Inskip HM, Godfrey KM, Law CM, Cooper C, West C, Robinson SM (2010) Group for Southampton women’s survey study: Breastfeeding, the use of docosahexaenoic acid-fortified formulas in infancy and neuropsychological function in childhood. Arch Dis Child 95(3):174–179, Epub 2010 Feb 4

    Article  Google Scholar 

  • Gheita T, Kamel S, Helmy N, El-Laithy N, Monir A (2012) Omega 3 fatty acids in juvenile idiopathic arthritis: effect on cytokines (IL-1 and TNF-α), disease activity and response criteria. Clin Rheumatol 31(2):363–366

    Article  Google Scholar 

  • Gibson RS, Kafwembe E, Mwanza S, Gosset L, Bailey KB, Mullen A, Baisley K, Filteau S (2011) A micronutrient-fortified food enhances iron and selenium status of Zambian infants but has limited efficacy on zinc. J Nutr 141(5):935–943, Epub 2011 Mar 16

    Article  CAS  Google Scholar 

  • Gore C, Custovic A, Tannock GW, Munro K, Kerry G, Johnson K, Peterson C, Morris J, Chaloner C, Murray CS, Woodcock A (2011) Treatment and secondary prevention effects of the probiotics Lactobacillus paracasei or Bifidobacterium lactis on early infant eczema: randomized controlled trial with follow-up until age 3 years. Clin Exp Allergy. doi:10.1111/j.1365-2222.2011.03885.x

  • Granado-Lorencio F, Herrero-Barbudo C, Olmedilla-Alonso B, Blanco-Navarro I, Pérez-Sacristán B (2010) Lutein bioavailability from lutein ester-fortified fermented milk: in vivo and in vitro study. J Nutr Biochem 21(2):133–139, Epub 2009 Feb 6

    Article  CAS  Google Scholar 

  • Green TJ, Skeaff CM, Rockell JE (2010) Milk fortified with the current adequate intake for vitamin D (5 microg) increases serum 25-hydroxyvitamin D compared to control milk but is not sufficient to prevent a seasonal decline in young women. Asia Pac J Clin Nutr 19(2):195–199

    CAS  Google Scholar 

  • Guerra PV, Lima LN, Souza TC, Mazochi V, Penna FJ, Silva AM, Nicoli JR, Guimarães EV (2011) Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind, controlled trial. World J Gastroenterol 17(34):3916–3921

    Article  Google Scholar 

  • Gutierres VO, Pinheiro CM, Assis RP, Vendramini RC, Pepato MT, Brunetti IL (2011) Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes. Br J Nutr 9:1–9

    Google Scholar 

  • Haider BA, Bhutta ZA (2006) Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev 4:CD004905. doi:10.1002/14651858.CD004905.pub2

    Google Scholar 

  • Hakimuddin F, Paliyath G, Meckling K (2006) Treatment of mcf-7 breast cancer cells with a red grape wine polyphenol fraction results in disruption of calcium homeostasis and cell cycle arrest causing selective cytotoxicity. J Agric Food Chem 54(20):7912–7923

    Article  CAS  Google Scholar 

  • Hakimuddin F, Paliyath G, Meckling K (2004) Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells. Breast Cancer Res Treat 85(1):65–79

    Article  CAS  Google Scholar 

  • Hao Q, Lu Z, Dong BR, Huang CQ, Wu T (2011) Probiotics for preventing acute upper respiratory tract infections. Cochrane Database of Systematic Reviews 9:CD006895. doi:10.1002/14651858.CD006895.pub2

    Google Scholar 

  • Hargis PS (1988) Modifying egg cholesterol in the domestic fowl. World Poult Sci J 44:17–29

    Article  Google Scholar 

  • Hargis PS, Van Elswyk ME (1993) Manipulating the fatty acid composition of poultry meat and eggs for the health conscious consumer. World’s Poultry Sci J 49:251–264

    Article  Google Scholar 

  • Health Canada (1998) Health Canada policy paper. http://www.hc-sc.gc.ca. Accessed on 22 December 2011.

  • Hernández ER, Jácome MM, Lee RG, Nakano T, Ozimek L, Guzmán IV (2007) High conjugated linoleic acid (CLA) content in milk and dairy products using a dietary supplementation of sunflower seed in cows. Thrombogenic/atherogenic risk issues. Arch Latinoam Nutr 57(2):173–178

    Google Scholar 

  • Hertrampf E, Cortés F, Erickson JD, Cayazzo M, Freire W, Bailey LB, Howson C, Kauwell GP, Pfeiffer C (2003) Consumption of folic acid-fortified bread improves folate status in women of reproductive age in Chile. J Nutr 133(10):3166–3169

    CAS  Google Scholar 

  • Hoisington D (2002) Opportunities for nutritionally enhanced maize and wheat varieties to combat protein and micronutrient malnutrition. Food Nutr Bull 23(4):376–377

    Google Scholar 

  • Horie K, Horie N, Abdou AM, Yang JO, Yun SS, Chun HN, Park CK, Kim M, Hatta H (2004) Suppressive effect of functional drinking yogurt containing specific egg yolk immunoglobulin on Helicobacter pylori in humans. J Dairy Sci 87(12):4073–4079

    Article  CAS  Google Scholar 

  • Høst A (1991) Importance of the first meal on the development of cow's milk allergy and intolerance. Allergy Proc 12(4):227–232

    Article  Google Scholar 

  • Hotz C, McClafferty B (2007) From harvest to health: challenges for developing biofortified staple foods and determining their impact on micronutrient status. Food Nutr Bull 28(2 Suppl):S271–279

    Google Scholar 

  • Houghton LA, Gray AR, Szymlek-Gay EA, Heath AL, Ferguson EL (2011) Vitamin D-fortified milk achieves the targeted serum 25-hydroxyvitamin D concentration without affecting that of parathyroid hormone in New Zealand toddlers. J Nutr 141(10):1840–1846, Epub 2011 Aug 10

    Article  CAS  Google Scholar 

  • Hsu FC, Wirtz M, Heppel SC, Bogs J, Krämer U, Khan MS, Bub A, Hell R, Rausch T (2011) Generation of Se-fortified broccoli as functional food: impact of Se fertilization on S metabolism. Plant Cell Environ 34(2):192–207. doi:10.1111/j.1365-3040.2010.02235.x. Epub 2010 Nov 11

    Article  CAS  Google Scholar 

  • Hu Y, McIntosh GH, Le Leu RK, Young GP (2010) Selenium-enriched milk proteins and selenium yeast affect selenoprotein activity and expression differently in mouse colon. Br J Nutr 104(1):17–23, Epub 2010 Mar 29

    Article  CAS  Google Scholar 

  • Hyvönen P, Suojala L, Haaranen J, von Wright A, Pyörälä S (2006) Human and bovine lactoferrins in the milk of recombinant human lactoferrin-transgenic dairy cows during lactation. Biotechnol J 1(4):410–412

    Article  CAS  Google Scholar 

  • IFIC (2011) Background on functional foods. http://www.foodinsight.org. Accessed on 22 December 2011

  • IOM/NAS (1994) Opportunities in the nutrition and food sciences: Research challenges and the next generation of investigators. In: Thomas PR, Earl R (eds) Food and Nutrition Board. National Academy Press, Washington

    Google Scholar 

  • Irvine SL, Hummelen R, Hekmat S (2011) Probiotic yogurt consumption may improve gastrointestinal symptoms, productivity, and nutritional intake of people living with human immunodeficiency virus in Mwanza, Tanzania. Nutr Res 31(12):875–881

    Article  CAS  Google Scholar 

  • Jayakanthan K, Shobana Devi R, Regina Mary R, Prabhavathi D, Vidya R, John M, Mahendri NV, Srinivasan P, Ramakrishna BS (2011) Effect of yoghurt containing Bifidobacterium lactis Bb12(R) on faecal excretion of secretory immunoglobulin A and human beta-defensin-2 in healthy adult volunteers. Nutr J 10:138–141

    Article  Google Scholar 

  • Johnston BC, Goldenberg JZ, Vandvik PO, Sun X, Guyatt GH (2011) Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev 9:CD004827. doi:10.1002/14651858.CD004827.pub3

    Google Scholar 

  • Jiang YH, McGeachin RB, Bailey CA (1994) a-tocopherol, ß-carotene and retinol enrichment of chicken eggs. Poultry Sci 73:1137–1143

    Article  CAS  Google Scholar 

  • Jiang Z, Ahn DU, Sim JS (1991) Effect of feeding flaxseed and two types of sunflower seed on fatty acid composition of yolk lipid classes. Poultry Sci 70:2467–2475

    Article  CAS  Google Scholar 

  • Jones PJ, MacDougall DE, Ntanios F, Vanstone CA (1997) Dietary phytosterols as cholesterol-lowering agents in humans. Can J Physiol Pharmacol 75(3):217–227

    Article  CAS  Google Scholar 

  • Johnston KE, Tamura T (2004) Folate content in commercial white and whole wheat sandwich breads. J Agric Food Chem 52(20):6338–6340

    Article  CAS  Google Scholar 

  • Kazimierczuk K, Cova L, Ndeboko B, Szczyrk U, Targosz A, Brzozowski T, Sirko A (2005) Genetic immunization of ducks for production of antibodies specific to Helicobacter pylori UreB in egg yolks. Acta Biochimica Polonica 52(1):261–266

    CAS  Google Scholar 

  • Kalaivani M, Sabitha R, Kalaiselvan V, Rajasekaran A (2010) Health benefits and clinical impact of major nutrient, Red yeast rice: A review. Food Bioprocess Technol 3(3):333–339

    Article  CAS  Google Scholar 

  • Karatzas CN (2003) Designer milk from transgenic clones. Nat Biotechnol 21(2):138–139

    Article  CAS  Google Scholar 

  • Karatzas CN, Turner JD (1997) Toward altering milk composition by genetic manipulation: current status and challenges. J Dairy Sci 80(9):2225–2232

    Article  CAS  Google Scholar 

  • Kandhro GA, Kazi TG, Sirajuddin KNF, Kazi N, Afridi HI, Baig JA, Shah AQ, Wadhwa SK, Khan S, Arain MB (2011) Effects of selenium supplementation on iodine and thyroid hormone status in a selected population with goitre in Pakistan. Clin Lab 57(7–8):575–585

    CAS  Google Scholar 

  • Raes K, Huyghebaert G, De Smet S, Nollet L, Arnouts S, Demeyer D (2002) The deposition of conjugated linoleic acids in eggs of laying hens fed diets varying in fat level and fatty acid profile. J Nutr 132(2):182–189

    CAS  Google Scholar 

  • Khush GS (2002) The promise of biotechnology in addressing current nutritional problems in developing countries. Food Nutr Bull 23(4):354–357

    Google Scholar 

  • Kim J, Ko Y, Park YK, Kim NI, Ha WK, Cho Y (2010) Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition 26(9):902–909

    Article  CAS  Google Scholar 

  • Kjeldsen-Kragh J, Lund JA, Riise T, Finnanger B, Haaland K, Finstad R, Mikkelsen K, Førre O (1992) Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis. J Rheumatol 19(10):1531–1536

    CAS  Google Scholar 

  • Kruger MC, Schollum LM, Kuhn-Sherlock B, Hestiantoro A, Wijanto P, Li-Yu J, Agdeppa I, Todd JM, Eastell R (2010) The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia. Bone 46(3):759–767

    Article  CAS  Google Scholar 

  • Kuntz S, Wenzel U, Daniel H (1999) Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr 38(3):133–142

    Article  CAS  Google Scholar 

  • Latté KP, Appel KE, Lampen A (2011) Health benefits and possible risks of broccoli - An overview. Food Chem Toxicol 49(12):3287–3309

    Article  CAS  Google Scholar 

  • Lee YS, Kang EY, Park MN, Choi YY, Jeon JW, Yun SS (2008) Effects of sn-2 palmitic acid-fortified vegetable oil and fructooligosaccharide on calcium metabolism in growing rats fed casein based diet. Nutr Res Pract 2(1):3–7

    Article  CAS  Google Scholar 

  • Lien TF, Chen SY, Shiau SP, Froman DP, Hu CY (1996) Chromium picolinate reduces laying hen serum and egg yolk cholesterol. The Professional Anim Scientist 12:77–80

    Google Scholar 

  • Lopez-Huertas E (2010) Health effects of oleic acid and long chain omega-3 fatty acids (EPA and DHA) enriched milks. A review of intervention studies. Pharmacol Res 61(3):200–207, Epub 2009 Nov 6

    Article  CAS  Google Scholar 

  • Lorea Baroja M, Kirjavainen PV, Hekmat S, Reid G (2007) Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clin Exp Immunol 149(3):470–479

    Article  CAS  Google Scholar 

  • Lugasi A (2009) Foods fortified with phytosterins: Their role in decreasing serum cholesterol level, their European community authorization and requirements for placing them on the market. Orv Hetil 150(11):483–496

    Article  Google Scholar 

  • Maggio L, Costa S, Gallini F (2009) Human milk fortifiers in very low birth weight infants. Early Hum Dev 85(10 Suppl):S59–S61

    Article  Google Scholar 

  • Magdalena Franczyk-Z˙ aro’w, Renata B. Kostogrys, Beata Szymczyk, Jacek Jawien, Mariusz Gajda,Tadeusz Cichocki, Leszek Wojnar, Stefan Chlopicki and Paweł M. Pisulewski (2008) Functional effects of eggs, naturally enriched with conjugated linoleic acid,on the blood lipid profile, development of atherosclerosis and composition of atherosclerotic plaque in apolipoprotein E and low-density lipoprotein receptor double-knockout mice (apoE/LDLR2/2) British Journal of Nutrition 99: 49–58

  • Malekshahi ZV, Gargari SL, Rasooli I, Ebrahimizadeh W (2011) Treatment of Helicobacter pylori infection in mice with oral administration of egg yolk-driven anti-UreC immunoglobulin. Microb Pathog 51(5):366–372

    Article  CAS  Google Scholar 

  • Martins EC, Krebs VL (2009) Effects of the use of fortified raw maternal milk on very low birth weight infants. J Pediatr (Rio J) 85(2):157–162

    Google Scholar 

  • Martin-Bautista E, Muñoz-Torres M, Fonolla J, Quesada M, Poyatos A, Lopez-Huertas E (2010) Improvement of bone formation biomarkers after 1-year consumption with milk fortified with eicosapentaenoic acid, docosahexaenoic acid, oleic acid, and selected vitamins. Nutr Res 30(5):320–326

    Article  CAS  Google Scholar 

  • McCowen KC, Ling PR, Decker E, Djordjevic D, Roberts RF, Coupland JN, Bistrian BR (2010) A simple method of supplementation of omega-3 polyunsaturated fatty acids: use of fortified yogurt in healthy volunteers. Nutr Clin Pract 25(6):641–645

    Article  Google Scholar 

  • McPherson RA, Hardy G (2011) Clinical and nutritional benefits of cysteine-enriched protein supplements. Curr Opin Clin Nutr Metab Care 14(6):562–568

    Article  CAS  Google Scholar 

  • Meier AH, Wilson JM (1997) Method of altering the contents of eggs. Patent:5665375. http://www.freepatentsonline.com/5665375.html

  • Meyer AL, Elmadfa I, Herbacek I, Micksche M (2007) Probiotic, as well as conventional yogurt, can enhance the stimulated production of proinflammatory cytokines. J Hum Nutr Diet 20(6):590–598

    Article  CAS  Google Scholar 

  • Mohan KV, Letchoumy PV, Hara Y, Nagini S (2008) Combination chemoprevention of hamster buccal pouch carcinogenesis by bovine milk lactoferrin and black tea polyphenols. Cancer Invest 26(2):193–201

    Article  CAS  Google Scholar 

  • Mukhtar H, Ahmad N (2000) Tea polyphenols: prevention of cancer and optimizing health. Am J Clin Nutr 71(6):1698S–1702S, discussion 1703S-1704S

    CAS  Google Scholar 

  • Mussner MJ, Parhofer KG, Von Bergmann K, Schwandt P, Broedl U, Otto C (2002) Effects of phytosterol ester-enriched margarine on plasma lipoproteins in mild to moderate hypercholesterolemia are related to basal cholesterol and fat intake. Metabolism 51(2):189–194

    Article  CAS  Google Scholar 

  • Napier JA, Graham IA (2010) Tailoring plant lipid composition: designer oilseeds come of age. Curr Opin Plant Biol 13(3):330–337, Epub 2010 Feb 23

    Article  CAS  Google Scholar 

  • Navarro-Alarcon M, Cabrera-Vique C (2008) Selenium in food and the human body: a review. Sci Total Environ 400(1–3):115–141, Epub 2008 Jul 26

    Article  CAS  Google Scholar 

  • NFHS (2007) International Institute for Population Sciences (IIPS) and ORC Macro (2007): National Family Health Survey-3, 2005–06. Volume-I, International Institute of Population Sciences, Mumbai, India

    Google Scholar 

  • Nikooyeh B, Neyestani TR, Farvid M, Alavi-Majd H, Houshiarrad A, Kalayi A, Shariatzadeh N, Gharavi A, Heravifard S, Tayebinejad N, Salekzamani S, Zahedirad M (2011) Daily consumption of vitamin D− or vitamin D + calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: a randomized clinical trial. Am J Clin Nutr 93(4):764–771, Epub 2011 Feb 2

    Article  CAS  Google Scholar 

  • Nomura S, Suzuki H, Masaoka T, Kurabayashi K, Ishii H, Kitajima M, Nomoto K, Hibi T (2005) Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils. Helicobacter 10(1):43–52

    Article  CAS  Google Scholar 

  • Odamaki T, Sugahara H, Yonezawa S, Yaeshima T, Iwatsuki K, Tanabe S, Tominaga T, Togashi H, Benno Y, Xiao JZ (2012) Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota. Anaerobe 18(1):14–18

    Article  Google Scholar 

  • Pariza MW (1992) Designer foods: effects on development of cancer. J Natl Cancer Inst Monogr 12:105–107

    Google Scholar 

  • Pathak P, Kapil U, Kapoor SK, Saxena R, Kumar A, Gupta N, Dwivedi SN, Singh R, Singh P (2004) Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana. Indian J Pediatr 71(11):1007–1014

    Article  Google Scholar 

  • Paton AW, Morona R, Paton JC (2006) Designer probiotics for prevention of enteric infections. Nat Rev Microbiol 4(3):193–200

    Article  CAS  Google Scholar 

  • Penny M, Kris-Etherton WilliamS Harris, Appel JL (2002) Fish consumption, fish oil, omega-3 fatty acids and cardiovascular disease. Circulation 106:2747–2757. doi:10.1161/01.CIR.0000038493.65177.94

    Article  Google Scholar 

  • Polagruto JA, Wang-Polagruto JF, Braun MM, Lee L, Kwik-Uribe C, Keen CL (2006) Cocoa flavanol-enriched snack bars containing phytosterols effectively lower total and low-density lipoprotein cholesterol levels. J Am Diet Assoc 106(11):1804–13

    Article  CAS  Google Scholar 

  • Potrykus I (2003) Nutritionally enhanced rice to combat malnutrition disorders of the poor. Nutr Rev 61(6 Pt 2):S101–104

    Article  Google Scholar 

  • Prinz C, Hafsi N, Voland P (2003) Helicobacter pylori virulence factors and the host immune response: implications for therapeutic vaccination. Trends Microbiol 11:134–138

    Article  CAS  Google Scholar 

  • Raileanu I, Diosady LL (2006) Vitamin A stability in salt triple fortified with iodine, iron, and vitamin A. Food Nutr Bull 27(3):252–259

    Google Scholar 

  • Rajasekaran A, Kalaivani M (2009) Anti-diabetic activity of aqueous extract of Monascus purpureus fermented rice in high cholesterol diet fed-streptozotocin-induced diabetic rats. Published online in Asian J Scientific Res 4:180–189

    Google Scholar 

  • Rajasekaran A, Kalaivani M (2011) Hypolipidemic and antioxidant activity of aqueous extract of Monascus purpureus fermented Indian rice in high cholesterol diet fed rats. Turk J Med Sci 41(1):25–32

    Google Scholar 

  • Reali A, Greco F, Fanaro S, Atzei A, Puddu M, Moi M, Fanos V (2010) Fortification of maternal milk for very low birth weight (VLBW) pre-term neonates. Early Hum Dev 86(1):33–36, Epub 2010 Apr 18

    Article  CAS  Google Scholar 

  • Rich-Edwards JW, Ganmaa D, Kleinman K, Sumberzul N, Holick MF, Lkhagvasuren T, Dulguun B, Burke A, Frazier AL (2011) Randomized trial of fortified milk and supplements to raise 25-hydroxyvitamin D concentrations in schoolchildren in Mongolia. Am J Clin Nutr 94(2):578–584, Epub 2011 Jun 22

    Article  CAS  Google Scholar 

  • Riediger ND, Azordegan N, Harris-Janz S, Ma DW, Suh M, Moghadasian MH (2009) Designer oils low in n-6:n-3 fatty acid ratio beneficially modifies cardiovascular risks in mice. Eur J Nutr 48(5):307–314, Epub 2009 Mar 31

    Article  CAS  Google Scholar 

  • Riediger ND, Othman R, Fitz E, Pierce GN, Suh M, Moghadasian MH (2008) Low n-6:n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice. Eur J Nutr 47(3):153–60

    Article  CAS  Google Scholar 

  • Rivera JA, Shamah T, Villalpando S, Monterrubio E (2010) Effectiveness of a large-scale iron-fortified milk distribution program on anemia and iron deficiency in low-income young children in Mexico. Am J Clin Nutr 91(2):431–439

    Article  CAS  Google Scholar 

  • Romeo J, Wärnberg J, García-Mármol E, Rodríguez-Rodríguez M, Diaz LE, Gomez-Martínez S, Cueto B, López-Huertas E, Cepero M, Boza JJ, Fonollá J, Marcos A (2011) Daily consumption of milk enriched with fish oil, oleic acid, minerals and vitamins reduces cell adhesion molecules in healthy children. Nutr Metab Cardiovasc Dis 21(2):113–120

    Article  CAS  Google Scholar 

  • Roe IH, Nam SU, Yang MR, Myung NH, Kim JT, Shin JH (2002) The promising effect of egg yolk antibody IgY on the treatment of Helicobacter pylori-associated gastric diseases. Kor J Gastroenterol 39:260–268

    Google Scholar 

  • Roth C, Magnus P, Schjølberg S, Stoltenberg C, Surén P, McKeague IW, Davey Smith G, Reichborn-Kjennerud T, Susser E (2011) Folic acid supplements in pregnancy and severe language delay in children. J Am Med Assoc 306(14):1566–1573

    Article  CAS  Google Scholar 

  • Roush JK, Dodd CE, Fritsch DA, Allen TA, Jewell DE, Schoenherr WD, Richardson DC, Leventhal PS, Hahn KA (2010) Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. J Am Vet Med Assoc 236(1):59–66

    Article  CAS  Google Scholar 

  • Ruggiero P, Peppoloni S, Berti D, Rappuoli R, Giudice GD (2002) New strategies for the prevention and treatment of Helicobacter pylori infection. Expert Opin Investig Drugs 11:1127–1138

    Article  CAS  Google Scholar 

  • Sabikhi L (2007) Designer milk. Adv Food Nutr Res 53:161–198

    Article  CAS  Google Scholar 

  • Satoh K, Kimura K, Taniguchi Y, Yoshida Y, Kihira K, Takimoto T, Kawata H, Saifuku K, Ido K, Takemoto T, Ota Y, Tada M, Karita M, Sakaki N, Hoshihara Y (1996) Distribution of inflammation and atrophy in the stomach of Helicobacter pylori-positive and -negative patients with chronic gastritis. Am J Gastroenterol 91:963–969

    CAS  Google Scholar 

  • Sautter C, Poletti S, Zhang P, Gruissem W (2006) Biofortification of essential nutritional compounds and trace elements in rice and cassava. Proc Nutr Soc 65(2):153–159

    Article  CAS  Google Scholar 

  • Sazawal S, Dhingra U, Dhingra P, Hiremath G, Sarkar A, Dutta A, Menon VP, Black RE (2010) Micronutrient fortified milk improves iron status, anemia and growth among children 1–4 years: a double masked, randomized, controlled trial. PLoS One 5(8):e12167. doi:10.1371/journal.pone.0012167

    Article  CAS  Google Scholar 

  • Scheideler SE, Froning G, Cuppett S (1997) Studies of Consumer Acceptance of High Omega-3 Fatty Acid Enriched Eggs. J Appl Poultry Res 6:137–146

    CAS  Google Scholar 

  • Seki S, Hidaka I, Kojima K, Yoshino H, Aoyama T, Okazaki M, Kondo K (2003) Effects of phytosterol ester-enriched vegetable oil on plasma lipoproteins in healthy men. Asia Pac J Clin Nutr 12(3):282–291

    CAS  Google Scholar 

  • Semba RD, Moench-Pfanner R, Sun K, de Pee S, Akhter N, Rah JH, Campbell AA, Badham J, Bloem MW, Kraemer K (2010) Iron-fortified milk and noodle consumption is associated with lower risk of anemia among children aged 6–59 mo in Indonesia. Am J Clin Nutr 92(1):170–176, Epub 2010 May 5

    Article  CAS  Google Scholar 

  • Servili M, Rizzello CG, Taticchi A, Esposto S, Urbani S, Mazzacane F, Di Maio I, Selvaggini R, Gobbetti M, Di Cagno R (2011) Functional milk beverage fortified with phenolic compounds extracted from olive vegetation water, and fermented with functional lactic acid bacteria. Int J Food Microbiol 147(1):45–52

    Article  CAS  Google Scholar 

  • Seshadri S (2001) Prevalence of micronutrient deficiency particularly of iron, zinc and folic acid in pregnant women in South East Asia. Br J Nutr 85(Suppl 2):S87–S92

    Article  CAS  Google Scholar 

  • SFDA State Food and Drug Administration, China. http://www.sfda.com. Accessed on 22 December 2011

  • Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A, Gharavi A, Kalayi A, Shariatzadeh N, Zahedirad M, Khalaji N, Haidari H (2011) Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. BMC Med 9:125–134

    Article  CAS  Google Scholar 

  • Shin JH, Roe IH, Kim HG (2004) Production of anti-Helicobacter pylori urease-specific immunoglobulin in egg yolk using an antigenic epitope of H. pylori urease. J Med Microbiol 53(Pt 1):31–34

    Article  CAS  Google Scholar 

  • Shin JH, Nam SW, Kim JT, Yoon JB, Bang WG, Roe IH (2003) Identification of immunodominant Helicobacter pylori proteins with reactivity to H. pylori-specific egg-yolk immunoglobulin. J Med Microbiol 52(Pt 3):217–222

    Article  CAS  Google Scholar 

  • Sim JS (1998) Designer eggs and their nutritional and functional significance. World Rev Nutr Diet 83:89–101

    Article  CAS  Google Scholar 

  • Sim SJ, Sunwoo HH (2002) Designer eggs: Nutritional and functional significance. In : Watson RR (ed) Egg and health promotion, 1st edn.Wiley-Blackwell, pp19–35.

  • Simopoulos AP (2000) Human requirement for n-3 polyunsaturated fatty acids. Poult Sci 79:961–970

    CAS  Google Scholar 

  • Sittig LJ, Herzing LB, Xie H, Batra KK, Shukla PK, Redei EE (2011) Excess folate during adolescence suppresses thyroid function with permanent deficits in motivation and spatial memory. Genes Brain Behav Nov 3. doi:10.1111/j.1601-183X.2011.00749.x

  • Sleator RD (2010) Probiotics—a viable therapeutic alternative for enteric infections especially in the developing world. Discov Med 10(51):119–124

    Google Scholar 

  • Sleator RD, Hill C (2008) New frontiers in probiotic research. Lett Appl Microbiol 46(2):143–147

    Article  CAS  Google Scholar 

  • Sookwong P, Nakagawa K, Nakajima S, Amano Y, Toyomizu M, Miyazawa T (2008) Tocotrienol content in hen eggs: its fortification by supplementing the feed with rice bran scum oil. Biosci Biotechnol Biochem 72(11):3044–3047, Epub 2008 Nov 7

    Article  CAS  Google Scholar 

  • Stuetz W, Carrara VI, McGready R, Lee SJ, Erhardt JG, Breuer J, Biesalski HK, Nosten FH (2011) Micronutrient status in lactating mothers before and after introduction of fortified flour: cross-sectional surveys in Maela refugee camp. Eur J Nutr. doi:10.1007/s00394-011-0226-z

  • Suárez M, Romero MP, Motilva MJ (2010) Development of a phenol-enriched olive oil with phenolic compounds from olive cake. J Agric Food Chem 58(19):10396–10403

    Article  CAS  Google Scholar 

  • Sunawang UB, Hidayat A, Kusharisupeni S (2009) Preventing low birth weight through maternal multiple micronutrient supplementation: a cluster-randomized, controlled trial in Indramayu, West Java. Food Nutr Bull 30(4 Suppl):S488–S495

    CAS  Google Scholar 

  • Surai PF, Sparks NHC (2001) Designer eggs: from improvement of egg composition to functional food. Trends Food Sci Technol 12(1):7–16

    Article  CAS  Google Scholar 

  • Surai PF, MacPherson A, Speake BK, Sparks NH (2000) Designer egg evaluation in a controlled trial. Eur J Clin Nutr 54(4):298–305

    Article  CAS  Google Scholar 

  • Trabulsi J, Capeding R, Lebumfacil J, Ramanujam K, Feng P, McSweeney S, Harris B, DeRusso P (2011) Effect of an α-lactalbumin-enriched infant formula with lower protein on growth. Eur J Clin Nutr 65(2):167–174, Epub 2010 Nov 10

    Article  CAS  Google Scholar 

  • Tseng KC, Fang TJ, Chiang S-S, Liu C-F, Wu C-L, Pan T-M (2012) Immunomodulatory activities and antioxidant properties of polysaccharides from Monascus-fermented products in vitro. J Sci Food Agric 92(7):1483–1489

    Google Scholar 

  • UNICEF (2005) Micronutrients - Iodine, Iron and Vitamin A. http://www.unicef.org/nutrition/index_iodine.html. Accessed on 22 December 2011

  • Van der Hee RM, Miret S, Slettenaar M, Duchateau GS, Rietveld AG, Wilkinson JE, Quail PJ, Berry MJ, Dainty JR, Teucher B, Fairweather-Tait SJ (2009) Calcium absorption from fortified ice cream formulations compared with calcium absorption from milk. J Am Diet Assoc 109(5):830–835

    Article  CAS  Google Scholar 

  • Wagner KH, Blauensteiner D, Schmid I, Elmadfa I (2005) The role of fortified foods–situation in Austria. Forum Nutr 57:84–90

    Article  Google Scholar 

  • Weisburger JH, Rivenson A, Aliaga C, Reinhardt J, Kelloff GJ, Boone CW, Steele VE, Balentine DA, Pittman B, Zang E (1998) Effect of tea extracts, polyphenols, and epigallocatechin gallate on azoxymethane-induced colon cancer. Proc Soc Exp Biol Med 217(1):104–108

    CAS  Google Scholar 

  • Wu TY, Tsai CC, Hwang YT, Chiu TH (2011) Effect of antioxidant activity and functional properties of chingshey purple sweet potato fermented milk by Lactobacillus acidophilus, L. delbrueckii subsp. lactis, and L. gasseri Strains. J Food Sci Dec 19. doi:10.1111/j.1750-3841.2011.02507.x

  • Xu J, Zhou X, Deng Q, Huang Q, Yang J, Huang F (2011) Rapeseed oil fortified with micronutrients reduces atherosclerosis risk factors in rats fed a high-fat diet. Lipids Health Dis 13(10):96

    Article  CAS  Google Scholar 

  • Yan L, Kerr PS (2002) Genetically engineered crops: their potential use for improvement of human nutrition. Nutr Rev 60(5 Pt 1):135–141

    Article  Google Scholar 

  • Yeom G, Yun DM, Kang YW, Kwon JS, Kang IO, Kim SY (2011) Clinical efficacy of facial masks containing yoghurt and Opuntia humifusa Raf. (F-YOP). J Cosmet Sci 62(5):505–514

    CAS  Google Scholar 

  • Zachariassen G, Faerk J, Grytter C, Esberg BH, Hjelmborg J, Mortensen S, Thybo Christesen H, Halken S (2011) Nutrient enrichment of mother’s milk and growth of very preterm infants after hospital discharge. Pediatrics 127(4):e995–e1003, Epub 2011 Mar 14

    Article  Google Scholar 

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Rajasekaran, A., Kalaivani, M. Designer foods and their benefits: A review. J Food Sci Technol 50, 1–16 (2013). https://doi.org/10.1007/s13197-012-0726-8

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