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Comparison Between Serum Insulin Levels and Its Resistance With Biochemical, Clinical and Anthropometric Parameters in South Indian Children and Adolescents

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Abstract

There is a rising trend in the prevalence of insulin resistance among obese, overweight children and adolescents. The serum insulin and its correlation with biochemical, clinical and anthropometric parameters were evaluated in 185 children and adolescents (59 control, 52 obese, 49 overweight, 25 congenital heart disease) of age group 10–17 years. The levels of serum insulin were measured by ELISA. Serum insulin levels were found to be significantly increased in children who were obese, overweight and had congenital heart disease, than controls. Serum insulin levels positively correlated with BMI, WHR, and serum C-peptide, serum leptin, total cholesterol, triglycerides, LDL-cholesterol, systolic and diastolic blood pressure. Fasting glucose levels were found to be negatively correlated with serum insulin levels. HDL-cholesterol levels were non-significant among the study groups. We identified nine obese children (five girls and four boys) with the features of metabolic syndrome and 69% of obese and overweight children were identified with insulin resistance. Insulin resistance was strongly associated with metabolic syndrome and its components, especially with central obesity and hypertriglyceridemia.

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References

  1. Castelli WP. Epidemiology of coronary heart disease: the Framingham study. Am J Med. 1984;76:4–12.

    Article  CAS  PubMed  Google Scholar 

  2. Despres JP, Lamarche B, Mauriege P, Cantin B, Dangenias GR, Moor Jani S, Lupin PJ. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Eng J Med. 1996;334(15):952–7.

    Article  CAS  Google Scholar 

  3. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents; the Bogalusa Heart Study. Pediatrics. 1999;103:1175–82.

    Article  CAS  PubMed  Google Scholar 

  4. Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults: the Bogalusa Heart Study. N Engl J Med. 1998;338:1650–6.

    Article  CAS  PubMed  Google Scholar 

  5. Asato Y, Katsuren K, Oshiro T, Kikawa K, Shimabukuro T, Ohta T. Relationship between lipid abnormalities and insulin resistance in Japanese school children. Arterioscler Thromb Vasc Biol. 2006;26:2781–6.

    Article  CAS  PubMed  Google Scholar 

  6. Graham TE, Yang Q, Bluher M, Hammarstedt A, et al. Retinol-binding protein 4 and insulin resistance in lean obese and diabetic subjects. N Engl J Med. 2006;354:2552–63.

    Article  CAS  PubMed  Google Scholar 

  7. Laakso M. How good a marker is insulin level for insulin resistance. Am J Epidemiol. 1993;137:959–65.

    CAS  PubMed  Google Scholar 

  8. Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet. 1992;340:925–9.

    Article  CAS  PubMed  Google Scholar 

  9. Moreno LA, Pineda I, Rodriguez G, Fleta J, Giner A, Juste MG, Sarria A, Bueno M. Leptin and metabolic syndrome in obese and non obese children. Horm Metab Res. 2002;34:394–9.

    Article  CAS  PubMed  Google Scholar 

  10. Hamidi A, Fakhrzadeh H, Moayyeri A, Heshmat R, Ebrahimpour P, Larinjani B. Metabolic syndrome and leptin concentrations in obese children. Indian J Pediatr. 2006;73(7):593–6.

    Article  PubMed  Google Scholar 

  11. Wu D-M, Shen M-H, Chu N-F. Relationship between plasma leptin levels and lipid profiles among school children in Taiwan—The Taipei children heart study. Eur J Epidemiol. 2001;17:911–6.

    Article  CAS  PubMed  Google Scholar 

  12. Steinberger J, Moorehead C, Katch V, Rocchini PAlbert. Relationship between insulin resistance and abnormal lipid profile in obese adolescents. J Pediatr. 1995;126:690–5.

    Article  CAS  PubMed  Google Scholar 

  13. Keskin M, Selimkurtoglu M, Kendirci M, Atabek E, Yazici C. Homeostasis Model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics. 2005;115:500–3.

    Article  Google Scholar 

  14. Chu N-F, Chang J-B, Shieh S-M. Plasma leptin, fatty acids and tumor necrosis factor-receptor and insulin resistance in children. Obes Res. 2003;11:532–40.

    Article  CAS  PubMed  Google Scholar 

  15. Arslanian S, Suprasongsin C. Insulin sensitivity, lipids, body composition in childhood: is “syndromex” present? J Clin Endocrinol Metab. 1996;81:1058–62.

    Article  CAS  PubMed  Google Scholar 

  16. Caprio S, Bronson M, Sherwin RS, Rife F, Tamborlane WV. Co-existence of severe insulin resistance and hyperinsulinemia in pre-adolescent obese children. Diabetologia. 1996;39:1489–97.

    Article  CAS  PubMed  Google Scholar 

  17. Franks PW, Brage S, Luan J, Ekelund U, Rahman M, Farooqui IS, et al. Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity. Obes Res. 2005;13:1476–84.

    Article  CAS  PubMed  Google Scholar 

  18. Jiang X, Srinivasan SR, Berenson GS. Relation of obesity to insulin secretion and clearance in adolescents: the Bogalusa Heart Study. Int J Obes Relat Metab Disord. 1996;20:951–6.

    CAS  PubMed  Google Scholar 

  19. Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, et al. Contribution of androgens to the gender differences in leptin production in obese children and adolescents. J Clin Invest. 1997;100:808–13.

    Article  CAS  PubMed  Google Scholar 

  20. Lundell K-H, Sabel K-G, Eriksson B, Mellgren G. Glucose metabolism and insulin secretion in children with cyanotic congenital heart disease. Acta Pediatr. 2008;86(10):1082–4.

    Article  Google Scholar 

  21. Nagy TR, Gower BA, Trowbridge CA, Degenberg C, Shewchuk RM, Goran MI. Effects of gender, ethnicity, body composition and fat distribution on serum leptin concentrations in children. J Clin Endocrinol Metab. 1997;82:2148–52.

    Article  CAS  PubMed  Google Scholar 

  22. Misra A, Vikram NK, Arya S, Pandey RM, Dhingra V, Chatterjea A, et al. High prevalence of insulin resistance in post pubertal Asian Indian children is associated with adverse truncal body fat patterning, abdominal adiposity and excess body fat. Int J Obes Relat Metab Disord. 2004;28:1217–26.

    Article  CAS  PubMed  Google Scholar 

  23. Falkner B, Hulman S, Kushner H. Insulin-stimulated glucose utilisation and borderline hypertension in young adult blacks. Hypertension. 1993;22:18–25.

    CAS  PubMed  Google Scholar 

  24. Dubey S, Kabra M, Bajpai A, Pandey RM, Hasan M, Gautam RK, Menon PS. Serum leptin levels in obese Indian children: relation to clinical and biochemical parameters. Indian Pediatr. 2007;44:257–62.

    PubMed  Google Scholar 

  25. Defronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14:173–94.

    Article  CAS  PubMed  Google Scholar 

  26. IDF Press Conference. The IDF Consensus world wide definition of the metabolic syndrome. http://www.idf.org/webdata/docs/IDF-Meta-syndrome_definition.pdf. Accessed 3 Feb 2006.

  27. Ramachandran A, Snehalatha C, Mohan V, Battacharyya PK, Viswanathan M. Decreased insulin sensitivity in offspring whose parents both have type 2 diabetes. Diabetes Med. 1990;7:331–4.

    Article  CAS  Google Scholar 

  28. Mieyer P, Faustinelli S, Cowan PA. Identifying children at risk for obesity, type 2 diabetes and cardiovascular disease. Diabetes Spectr. 2005;18:213–20.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, International Centre for Cardio-Thoracic and Vascular Diseases, Dr. K.M. Cherian Heart Foundation, R-30-C, Ambattur Industrial Estate Road, Chennai, 600 101, India

    G. Srinivasa Nageswara Rao, Gurumurthy Prema, Gururajan Priya, Sarasa Barathi Arumugam & R. Saibabu

  2. Department of Cardiology, International Centre for Cardio-Thoracic and Vascular Diseases, Dr. K.M. Cherian Heart Foundation, Mogappair, Chennai, 600 101, India

    V. Kirthivasan & K. M. Cherian

Authors
  1. G. Srinivasa Nageswara Rao
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  2. Gurumurthy Prema
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  3. Gururajan Priya
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  4. Sarasa Barathi Arumugam
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  5. V. Kirthivasan
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  6. R. Saibabu
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  7. K. M. Cherian
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Correspondence to Gurumurthy Prema.

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Srinivasa Nageswara Rao, G., Prema, G., Priya, G. et al. Comparison Between Serum Insulin Levels and Its Resistance With Biochemical, Clinical and Anthropometric Parameters in South Indian Children and Adolescents. Ind J Clin Biochem 26, 22–27 (2011). https://doi.org/10.1007/s12291-010-0069-z

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  • DOI: https://doi.org/10.1007/s12291-010-0069-z

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