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BCR-ABL Translocation in Pediatric Acute Lymphoblastic Leukemia in Southern India

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Abstract

Cytogenetics and polymerase chain reaction (PCR) based assays provide important information regarding biologically defined and prognostically relevant subgroups in acute leukemias. We utilized karyotyping and molecular analysis by reverse transcriptase PCR for the BCR-ABL translocation, in addition to morphological study, cytochemistry and immunophenotyping, to study 24 cases of pediatric acute lymphoblastic leukemia (ALL). Our objective was to determine the frequency of the BCRABL translocation in childhood ALL from southern India. Karyotyping showed one case of hyperdiploidy, one case of t (12; 21) translocation and one case of 46, XY-21+mar. The BCR-ABL translocation was found in 8.3% of these cases. One of these was a cryptic translocation, the karyotype being normal. BCR-ABL positivity in ALL is associated with aggressive disease and has been shown to be a poor prognostic factor, especially in children.

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Authors and Affiliations

  1. Department of Pathology, Dr. A. L. Mudaliar Post-graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600113, India

    D. Sugapriya, S. Preethi & P. Shanthi

  2. Department of Genetics, Dr. A. L. Mudaliar Post-graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600113, India

    N. Chandra & G. Jeyaraman

  3. Department of Medical Biochemistry, Dr. A. L. Mudaliar Post-graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600113, India

    P. Sachdanandam

  4. Department of Hematology Oncology, Institute of Child Health and Hospital for Children, Egmore, Chennai, 60008, India

    S. Thilagavathy & S. Venkatadesilalu

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  1. D. Sugapriya
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  2. S. Preethi
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  3. P. Shanthi
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  4. N. Chandra
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  5. G. Jeyaraman
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  6. P. Sachdanandam
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  7. S. Thilagavathy
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  8. S. Venkatadesilalu
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Correspondence to P. Shanthi.

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Sugapriya, D., Preethi, S., Shanthi, P. et al. BCR-ABL Translocation in Pediatric Acute Lymphoblastic Leukemia in Southern India. Indian J Hematol Blood Transfus 28, 37–41 (2012). https://doi.org/10.1007/s12288-011-0096-9

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  • DOI: https://doi.org/10.1007/s12288-011-0096-9

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