Abstract
Animal models are a useful tool to study pathomechanisms and therapeutic targets in biomedical research. In the last decade the investigation of different humanized mouse models became important in research. The existence of human immune cells in immunodeficient mice allows the bridging between rodent model and human immune system. The method of choice to characterize these humanized mice is flow cytometry. Here, we explain facts about human immune cells in mice and show how to detect them.
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Franziska Lange, Johanna Scholbach, Anja Rodewohl und Margarethe Köberle (v. l. n. r.)
Die Arbeitsgruppenleiterin Dr. Franziska Lange, die Doktorandin Johanna Scholbach sowie die wissenschaftlichen Mitarbeiterinnen Anja Rodewohl und Margarethe Köberle arbeiten seit 2010 am Projekt „humanisierte Maus“ des Fraunhofer-Instituts für Zelltherapie und Immunologie, Leipzig. Im Vordergrund stehen die Charakterisierung des Mausmodells sowie die wissenschaftliche Nutzung im Krankheitsmodell.
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Scholbach, J., Köberle, M., Rodewohl, A. et al. Detektion von menschlichen Immunzellen in der humanisierten Maus. Biospektrum 19, 37–40 (2013). https://doi.org/10.1007/s12268-013-0269-1
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DOI: https://doi.org/10.1007/s12268-013-0269-1