Skip to main content

Advertisement

SpringerLink
Log in

Angiomatoid Fibrous Histiocytoma: Pleomorphic Variant Associated with Multiplication of EWSR1-CREB1 Fusion Gene

  • Communication
  • Published:
Pathology & Oncology Research

Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor which exceptionally occurs in visceral organs or bones. Histologically this is a bland, monomorphic tumor and only occasionally shows pleomorphism. Vast majority of the soft tissue cases share the same translocation and the resulting EWSR1-CREB1 gene fusion as background pathogenetic alteration. Here we report a 10-year-old boy with subcutaneous tumor of the right shoulder. Histological, immunohistochemical and FISH analyses of the case revealed pleomorphic phenotype, characteristic immunophenotype and multiplication of the EWSR1-CREB1 fusion gene in the nuclei of the tumor cells. The possible explanation of the fusion gene multiplication, its relation to the morphology and the clinical outcome are discussed in the context of the published literature.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Enzinger FM (1979) Angiomatoid malignant fibrous histiocytoma: a distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm. Cancer 44(6):2147–2157

    Article  PubMed  CAS  Google Scholar 

  2. Fletcher CDM (1991) Angiomatoid “malignant fibrous histiocytoma”: an immunohistochemical study indicative of myoid differentiation. Hum Pathol 22(6):563–568

    Article  PubMed  CAS  Google Scholar 

  3. Fanburg-Smith JC, Miettinen M (1999) Angiomatoid “malignant” fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. Hum Pathol 30(11):1336–1343

    Article  PubMed  CAS  Google Scholar 

  4. Tanas MR, Rubin BP, Montgomery EA et al (2010) Utility of FISH in the diagnosis of angiomatoid fibrous histiocytoma: a series of 18 cases. Mod Pathol 23:93–97

    Article  PubMed  CAS  Google Scholar 

  5. Waters BL, Panagopoulos I, Allen EF (2000) Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF genes induced by a chromosomal translocation involving bands 12q13 and 16p11. Cancer Genet Cytogenet 121:109–116

    Article  PubMed  CAS  Google Scholar 

  6. Hallor KH, Micci F, Meis-Kindblom JM et al (2007) Fusion genes in angiomatoid fibrous histiocytoma. Cancer Lett 251(1):158–163

    Article  PubMed  CAS  Google Scholar 

  7. Antonescu CR, Dal Cin P, Nafa K et al (2007) EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. Genes Chromosomes Cancer 46(12):1051–1060

    Article  PubMed  CAS  Google Scholar 

  8. Rossi S, Szuhai K, Ijszenga M et al (2007) EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res 13(24):7322–7328

    Article  PubMed  CAS  Google Scholar 

  9. Costa MJ, Weiss SW (1990) Angiomatoid malignant fibrous histiocytoma. A follow-up study of 108 cases with evaluation of possible histologic predictors of outcome. Am J Surg Pathol 14(12):1126–1132

    Article  PubMed  CAS  Google Scholar 

  10. Weinreb I, Rubin BP, Goldblum JR (2008) Pleomorphic angiomatoid fibrous histiocytoma: a case confirmed by fluorescence in situ hybridization analysis for EWSR1 rearrangement. J Cutan Pathol 35(9):855–860

    Article  PubMed  Google Scholar 

  11. Matsumura T, Yamaguchi T, Tochigi N et al (2010) Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridization. J Clin Pathol 63(2):124–128

    Article  PubMed  CAS  Google Scholar 

  12. Moura RD, Wang X, Lonzo ML et al (2011) Reticular angiomatoid “malignant” fibrous histiocytoma-a case report with cytogenetics and molecular genetic analyses. Hum Pathol 42(9):1359–1363

    Article  PubMed  Google Scholar 

  13. Mangham DC, Williams A, Lalam RK et al (2010) Angiomatoid fibrous histiocytoma of bone: a calcifying sclerosing variant mimicking osteosarcoma. Am J Surg Pathol 34:279–285

    Article  PubMed  Google Scholar 

  14. Ren L, Guo SP, Zhou XG et al (2009) Angiomatoid fibrous histiocytoma. First report of primary pulmonary origin. Am J Surg Pathol 33:1570–1574

    Article  PubMed  Google Scholar 

  15. Dunham C, Hussong J, Seiff M et al (2008) Primary intracerebral angiomatoid fibrous histiocytoma. Report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes. Am J Surg Pathol 32:478–484

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

We would like to thank Horváth Eszter Beáta, Department of Pathology, II. Diagnostic Laboratory, for her technical assistance provided in this study.

Conflict of interest statement

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology, II. Diagnostic Laboratory, Faculty of Medicine, Clinical Center, Pécs University, Rákóczi út 2., 7623, Pécs, Hungary

    Tamás Tornóczky

  2. Department of Pathology, Balassa János County Hospital, Szekszárd, Hungary

    Barna Bogner

  3. Department of Anatomic and Surgical Pathology, University of Chicago, Chicago, IL, USA

    Thomas Krausz

  4. Department of Pediatrics, Oncohaematology Division, Faculty of Medicine, Clinical Center, Pécs University, Pécs, Hungary

    Gábor Ottóffy

  5. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

    Károly Szuhai

Authors
  1. Tamás Tornóczky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Barna Bogner
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thomas Krausz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gábor Ottóffy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Károly Szuhai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tamás Tornóczky.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tornóczky, T., Bogner, B., Krausz, T. et al. Angiomatoid Fibrous Histiocytoma: Pleomorphic Variant Associated with Multiplication of EWSR1-CREB1 Fusion Gene. Pathol. Oncol. Res. 18, 545–548 (2012). https://doi.org/10.1007/s12253-011-9468-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-011-9468-6

Keywords

Search

Navigation