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Clinical characteristics of human immunodeficiency virus-associated Hodgkin lymphoma patients in Japan

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Abstract

The incidence of Hodgkin lymphoma (HL) is paradoxically increasing in the combination anti-retroviral therapy (cART) era. However, there has been no nationwide survey of human immunodeficiency virus (HIV)-associated HL (HIV-HL) in Japan. We retrospectively examined the clinical characteristics and outcomes of 19 newly diagnosed HIV-HL patients at 11 HIV/AIDS and hematology regional hospitals in Japan between 1991 and 2010. At the time of HL diagnosis, 79 % of patients were receiving cART. All the patients, but one received HL diagnoses in the cART era. The median CD4+ cell count at HIV-HL diagnosis was 169/μl. Mixed-cellularity classical Hodgkin lymphoma was the most common subtype occurring in 68 % of the patients; 89 % of the patients were positive for Epstein–Barr virus. Of these 19 patients, 84 % were in advanced stages, with bone marrow involvement observed in 47 % of the patients; 58 % had extranodal sites. All the treated patients were given cART concurrent with HL therapy. The complete remission rate of the treated patients was 87 %. The median OS of the entire cohort was 17 months. These results suggest that the characteristics of HIV-HL in Japan are more aggressive than those of non-HIV-associated HL in Japan, but standard chemotherapy is effective and feasible.

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Acknowledgments

We are indebted to Mr. Roderick J. Turner, Associate Professor Edward F. Barroga and Professor J. Patrick Barron, Chairman of the Department of International Medical Communications of Tokyo Medical University, for their editorial review of the English manuscript.

Conflict of interest

This study was supported in part by a Health and Labour Sciences Research Grant from the Ministry of Health, Labour, and Welfare of Japan (grant number: H22-AIDS-I-002).

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Authors and Affiliations

  1. Department of Laboratory Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Mihoko Yotsumoto & Katsuyuki Fukutake

  2. Division of Hematology, National Center for Global Health and Medicine, Tokyo, Japan

    Shotaro Hagiwara

  3. Division of Infectious Disease, Tokyo Metropolitan Cancer and Infectious Disease Center, Komagome Hospital, Tokyo, Japan

    Atsushi Ajisawa

  4. AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan

    Junko Tanuma

  5. Department of Infectious Disease, National Hospital Organization Osaka National Hospital, Osaka, Japan

    Tomoko Uehira

  6. Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan

    Hirokazu Nagai

  7. Division of Internal Medicine, Nagano Prefectural Foundation of Agricultural Cooperative for Health and Welfare, Saku Central Hospital, Nagano, Japan

    Yuko Fujikawa

  8. Division of Chemotherapy, Hachinohe City Hospital, Aomori, Japan

    Shunichi Maeda

  9. Division of Internal Medicine, Matsumoto Medical Center, Nagano, Japan

    Kiyoshi Kitano

  10. Department of Hematology, The Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan

    Nobuyoshi Arima

  11. Center for Infectious Diseases, Nara Medical University Hospital, Nara, Japan

    Kenji Uno

  12. Division of Hematology, Kyoto First Red Cross Hospital, Kyoto, Japan

    Toshiki Iwai

  13. Division of Infectious Disease, Musashino Red Cross Hospital, Tokyo, Japan

    Igen Hongo

  14. Division of Pathology, Toranomon Hospital, Tokyo, Japan

    Yasunori Ota

  15. Center for AIDS Research, Kumamoto University, Kumamoto, Japan

    Seiji Okada

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  1. Mihoko Yotsumoto
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  2. Shotaro Hagiwara
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Correspondence to Mihoko Yotsumoto.

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Yotsumoto, M., Hagiwara, S., Ajisawa, A. et al. Clinical characteristics of human immunodeficiency virus-associated Hodgkin lymphoma patients in Japan. Int J Hematol 96, 247–253 (2012). https://doi.org/10.1007/s12185-012-1127-5

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  • DOI: https://doi.org/10.1007/s12185-012-1127-5

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