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Relationship Between Amounts of Daily Cigarette Consumption and Abdominal Obesity Moderated by CYP2A6 Genotypes in Chinese Male Current Smokers

  • Original Article
  • Published:
Annals of Behavioral Medicine

Abstract

Background

Cigarette smoking is an important risk factor for abdominal obesity. However, the degree to which the CYP2A6 genotype moderates the relationship between smoking and abdominal obesity has not been established.

Purpose

This study aims to investigate whether or not the relationship between smoking quantity and abdominal obesity is influenced by CYP2A6 genotypes.

Methods

Nine hundred fifty-four male current smokers were selected. A venous specimen was collected to test serum cotinine and CYP2A6 genotype, and all smokers were divided into heavy (>15 cigarettes/day) and light smokers (≤15 cigarettes/day).

Results

Heavy smoking increased the risk of abdominal obesity (odds ratio (OR) = 1.57; 95% CI, 1.13–2.19) compared with light smoking. Furthermore, heavy smoking had a positive interactive effect with CYP2A6 poor metabolizer genotype on abdominal obesity (OR = 3.90; 95% CI, 1.25–12.18). Moreover, CYP2A6 poor metabolizer genotypes were associated with slower nicotine metabolism.

Conclusions

Heavy smoking may increase the risk of abdominal obesity—particularly in smokers with CYP2A6 poor metabolizer genotypes.

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Acknowledgments

This study was funded by the Guangzhou Health Bureau (2005-Zda-001). National Institute on Drug Abuse/National Institutes of Health grants K08-014276 and R21-027331. We also acknowledge the financial support from the Centre for Addiction and Mental Health (RFT QZ) and Canadian Institutes for Health Research MOP86471. This study was completed with the assistance of the following units: Disease Prevention and Control Center of Haizhu District and Baiyun District, the Health Inspection Institute of Huangpu District, the Sixth Affiliated Hospital of Sun Yat-sen University, and the Health Care Center of Huayin Community, Jinyang Community, Longteng Community, and the Department of Health Education of Liwan Hospital.

Conflicts of interest statement

Dr. Tyndale owns shares and participates in Nicogen Research Inc., a company focused on novel smoking cessation treatment approaches. No Nicogen funds were used in this work, and no other Nicogen participants reviewed the manuscript. Dr. Tyndale has also consulted for Novartis. All other authors have no conflicts of interests to declare.

Author information

Authors and Affiliations

  1. Department of Biostatistics and Epidemiology, School of Public Health, Sun Yat-Sen University, 74, Zhongshan Road 2, Guangzhou, China

    Tao Liu Ph.D., Hui Wang Ph.D. & Wei-Qing Chen Ph.D.

  2. Center for Education in Family and Community Medicine, 1215 Welch Road, Modular G, Stanford, CA, 94305, USA

    Sean P. David MD

  3. The Center for Addiction and Mental Health and the Departments of Pharmacology and Toxicology and Psychiatry, University of Toronto, Toronto, ON, M5S 1A8, Canada

    Rachel F. Tyndale Ph.D. & Qian Zhou Ph.D.

  4. Department of Nephrology, The First Affiliated Hospital of Sun Yat-Sen University, 58, Zhongshan Road 2, Guangzhou, China

    Xue-Qing Yu Ph.D. & Wei Chen Ph.D.

  5. Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, 74, Zhongshan Road 2, Guangzhou, China

    Tao Liu Ph.D., Hui Wang Ph.D. & Wei-Qing Chen Ph.D.

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  1. Tao Liu Ph.D.
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  2. Sean P. David MD
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  7. Qian Zhou Ph.D.
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  8. Wei-Qing Chen Ph.D.
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Correspondence to Wei-Qing Chen Ph.D..

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Liu, T., David, S.P., Tyndale, R.F. et al. Relationship Between Amounts of Daily Cigarette Consumption and Abdominal Obesity Moderated by CYP2A6 Genotypes in Chinese Male Current Smokers. ann. behav. med. 43, 253–261 (2012). https://doi.org/10.1007/s12160-011-9318-5

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  • DOI: https://doi.org/10.1007/s12160-011-9318-5

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