Abstract
While hepatocellular carcinoma (HCC) is a relatively common tumour with an annual incidence in the EU of 8 cases/100,000 inhabitants, bile tract carcinoma (BTC) is much less common, with an incidence of 4 cases per 100,000 inhabitants per year. In both cases, when planning treatment it is essential to perform accurate staging, evaluate hepatic functional reserve and performance status, and obtain the opinion of the patient. The only curative treatment is surgery. However, several interventional radiological techniques can help to achieve local disease control and the alleviation of symptoms. In addition, sorafenib (HCC) and chemotherapy (BTC) may contribute to prolong survival in patients with disseminated disease. Therefore, the therapeutic strategy should always be discussed and planned within a multidisciplinary tumour board.
Similar content being viewed by others
References
Ferlay J, Parkin DM, Pisani P (2010) GLOBOCAN 2009:cancer incidence and mortality worldwide: IARC Cancer Base No. 10. International Agency for Research on Cancer, Lyon, France. http://globocan.iarc.fr
Zhang BH, Yang BH, Tang ZY (2004) Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol 130:417–422
Forner A, Ayuso C, Real MI et al (2009) Diagnosis and treatment of hepatocellular carcinoma. Med Clin 132:272–286
Jelic S, Sotiropoulos GC (2010) Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 21[Suppl 5]:v59–v64
NCCN (2010) Hepatobiliary Cancers. NCCN Practice Guidelines in Oncology v.1.2010
Bruix J, Sherman M (2005) Management of hepatocellular carcinoma. Hepatology 42:1208–1236
Dong J, Roberts LR (20100 Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol 7:448–458
Llovet J, Bru C, Bruix J (1999) Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 19:329–338
Forner A, Reig ME, Rodríguez-Lope C et al (2010) Current strategy for staging and treatment: the CCLC update and future prospects. Semin Liver Dis 1:61–74
Thomas MB, Jaffe D, Choti MM et al (2010) Hepatocellular carcinoma: consensus recomendations of the National Cancer Institute Clinical Trials Planning Meeting. J Clin Oncol 28:3994–4005
Llovet JM, Ricci S, Mazzaferro V et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359:378–390
Cheng AL, Kang YK, Chen Z et al (2009) Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomized, double-blind, placebo-controlled trial. Lancet Oncol 10:25–34
Peck-Radosavljevic M, Greten TF, Lammer J et al (2010) Consensus on the current use of sorafenib for the treatment of hepatocellular carcinoma. Eur J Gastroenterol Hepatol 22:391–398
Eckel F, Brunner T, Jelic S (2010) Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol [Suppl 6]:v65–v69
Aljiffry M, Wlash MJ, Molinari M (2009) Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990–2009. World J Gastroenterol 15:4240–4262
Blechacz B, Gores GJ (2008) Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 48:308–321
Miyakawa S, Ishihara S, Takada T et al (2008) Flowchart for the management of biliary tract and ampullary carcinomas. J Hepatobiliary Pancreat Surg 15:7–14
Mosconi S, Beretta GD, Labianca R et al (2009) Cholangiocarcinoma. Crit Rev Oncol Hematol 69:259–270
Glimelius B, Hoffman K, Sjöden PO et al (1996) Chemotherapy improves survival and quality of life in advanced pancreatic and biliary cancer. Ann Oncol 7:593–600
Valle J, Wasan H, Palmer DH et al (2010) Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med 362:1273–1281
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Feliu, J., Sastre, J., Maurel, J. et al. Hepatocellular and biliary tract carcinomas: SEOM clinical guidelines. Clin Transl Oncol 13, 536–544 (2011). https://doi.org/10.1007/s12094-011-0694-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12094-011-0694-x