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Response to erlotinib in recurrent glioblastoma multiforme showing coexpression of EGFRvIII and PTEN

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Abstract

Glioblastoma multiforme (GBM) is the most aggressive brain tumour in adults and remains incurable despite multimodal intensive treatment regimens. We present a patient with a recurrent glioblastoma who showed coexpression of the epidermal growth factor receptor mutant variant III (EGFRvIII) and the tumour-suppressor protein PTEN. She was treated with the tyrosine kinase inhibitor erlotinib for four months, achieving a partial response with improvement of neurologic symptoms. A review of the pertinent literature supporting the future use of therapies against epidermal growth factor receptor (EGFR) in highgrade gliomas is also provided.

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Authors and Affiliations

  1. Medical Oncology Department, Hospital Universitario Clínico San Carlos, C/ Profesor Martín Lagos, s/n, ES-28040, Madrid, Spain

    Ana Custodio, Antonio Calles & Pedro Pérez-Segura

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  1. Ana Custodio
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  2. Antonio Calles
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  3. Pedro Pérez-Segura
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Correspondence to Ana Custodio.

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Custodio, A., Calles, A. & Pérez-Segura, P. Response to erlotinib in recurrent glioblastoma multiforme showing coexpression of EGFRvIII and PTEN. Clin Transl Oncol 12, 310–314 (2010). https://doi.org/10.1007/s12094-010-0510-z

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  • DOI: https://doi.org/10.1007/s12094-010-0510-z

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