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Gemcitabine-based combination regimen in patients with peripheral T-cell lymphoma

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Abstract

This study was conducted to evaluate the efficacy and safety of gemcitabine-based combination regimen in patients with peripheral T-cell lymphoma (PTCL). Between May 2007 and August 2011, 26 consecutive patients with PTCL were enrolled in this study. Of these 26 patients, histology was extranodal NK/T-cell lymphoma, nasal type in 14 (53.9 %), peripheral T-cell lymphoma, not otherwise specified in nine (34.6 %), anaplastic large cell lymphoma, ALK negative in three (11.5 %). The majority of patients had newly diagnosed (65.4 %) and advanced (80.8 %) diseases. Treatment regimen was DIMG (dexamethasone, ifosfamide, methotrexate, and gemcitabine) given to the first 6 patients, and GDP (gemcitabine, dexamethasone, and cisplatin) given to the remaining 20 patients. The median follow-up time was 25 (range 7–60) months. The overall response rate was 88.5 %. Twelve (46.2 %) patients achieved complete remission, 11 (42.3 %) patients achieved partial remission, and 1 (3.8 %) patient had stable disease (SD), two (7.7 %) patients had progressive diseases. The 1- and 2-year progression-free survival rates were 58.7 and 45.9 %, while 1- and 2-year overall survival rates for all patients were 80.6 and 63.7 %, respectively. Adverse events included grade 3 or 4 neutropenia (35.0 %) and thrombocytopenia (15.0 %) from patients treated with GDP. Grade 3 or 4 neutropenia and thrombocytopenia were 100.0 and 66.7 %, respectively, for patients who received DIMG regimen. Our study has demonstrated that the gemcitabine-based combination regimen, especially GDP regimen, is safe and well tolerated with promising clinical activity in patients with PTCLs.

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Authors and Affiliations

  1. Department of Medical Oncology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), No. 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, People’s Republic of China

    Mei Dong, Xiao-hui He, Peng Liu, Yan Qin, Jian-liang Yang, Sheng-yu Zhou, Sheng Yang, Chang-gong Zhang, Lin Gui, Li-qiang Zhou & Yuan-kai Shi

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  1. Mei Dong
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  2. Xiao-hui He
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Correspondence to Yuan-kai Shi.

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Dong, M., He, Xh., Liu, P. et al. Gemcitabine-based combination regimen in patients with peripheral T-cell lymphoma. Med Oncol 30, 351 (2013). https://doi.org/10.1007/s12032-012-0351-4

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