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Serum levels of 25-hydroxyvitamin D are associated with cognitive impairment in type 2 diabetic adults

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Abstract

Hypovitaminosis D is highly prevalent in type 2 diabetes. The aim of this study is to determine the serum levels of 25-hydroxyvitamin D [25(OH)D] in type 2 diabetic patients with and without mild cognitive impairment (MCI), and examine the relationship of 25(OH)D and MCI with other clinical factors. One hundred and sixty-five diabetic patients were enrolled in this study. Among whom, 95 patients were considered as MCI [Montreal Cognitive Assessment score (MoCA) < 26] and the other 70 as no MCI (MoCA ≥ 26). Subjects were assessed clinically. Diabetic patients with MCI had a longer duration of DM, fewer years of education, elevated fasting blood glucose (FBG), resistant index (RI) of carotid, and lower levels of 25(OH)D {[17.35 (13.02–25.92) vs 28.00 (19.67–34.30)] ng/ml, P < 0.001}. The MoCA score was positively correlated with log10[25(OH)D], education year, and inversely correlated with duration of DM, history of hypertension, intima-media thickness (IMT), FBG, max-RI, and min-RI. Log10[25(OH)D] was positively correlated with MoCA score, and inversely correlated with IMT, in multivariate regression analysis adjusted for age, sex, and education year, 25(OH)D (β = 0.210, P = 0.003), history of hypertension (β = −0.191, P = 0.007), IMT (β = −0.194, P = 0.007), and FBG (β = −0.157, P = 0.026) independently predicted MoCA score. In conclusion, our results suggest that levels of serum 25(OH)D are inversely associated with the cognitive impairment in diabetic patients. Vitamin D may be a potential protective factor for cognitive impairment in patients with type 2 diabetes.

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Acknowledgments

This work was supported by a joint research project of Shanghai health bureau (2010Y047, to R. C), Shanghai Pudong New Area health bureau (PWRq2012-09, to R. C), and science committee of Shanghai Pudong New Area (PKJ2010-Y25, to X. J). X. J designed the study and reviewed and edited the manuscript. R.C wrote and edited the manuscript, and researched data. X. Z reviewed and edited the manuscript, Z. G, P. G, B. Z, Z. Z, L. X, Y. Q researched data.

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The authors declare that they have no conflict of interest concerning this article.

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Authors and Affiliations

  1. Department of Endocrinology, Shanghai Pudong New Area People’s Hospital, No.490, South Chuanhuan Road, Shanghai, China

    Rui-hua Chen, Zhe Gu, Pei-li Gu, Bin Zhou, Zhen-hong Zhu, Lin-yan Xu, Yu-feng Zou & Xiao-zhen Jiang

  2. Department of Neurology, Shanghai Pudong New Area People’s Hospital, Shanghai, China

    Xiao-hui Zhao

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  1. Rui-hua Chen
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Correspondence to Xiao-zhen Jiang.

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Chen, Rh., Zhao, Xh., Gu, Z. et al. Serum levels of 25-hydroxyvitamin D are associated with cognitive impairment in type 2 diabetic adults. Endocrine 45, 319–324 (2014). https://doi.org/10.1007/s12020-013-0041-9

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  • DOI: https://doi.org/10.1007/s12020-013-0041-9

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