Skip to main content
SpringerLink
Log in

A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin

  • Original Article
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

Ischemia-modified albumin (IMA) is a novel marker of tissue ischemia. Nowadays, IMA is accepted as a marker of oxidative stress. In this study, we aimed at establishing an association between IMA and hyperglycemia, blood pressure, lipid parameters, microvascular complications, hsCRP, and microalbuminuria in type 2 diabetes patients without overt macrovascular disease and acute ischemia. Fifty type 2 diabetes mellitus patients without a history of macrovascular disease or end-stage renal disease were enrolled into the study. Age-matched 30 healthy individuals were also included in the study as a control group. Plasma IMA (0.329 ± 0.046 and 0.265 ± 0.045 AbsU; P < 0.0001) and hsCRP levels (0.51 ± 0.36 and 0.32 ± 0.17 mg/dl; P < 0.0001) were significantly higher in the diabetic group compared to healthy controls. IMA level was significantly correlated with hsCRP (r = 0.76; P < 0.0001), HbA1c (r = 0.72; P < 0.0001), microalbuminuria (r = 0.40; P = 0.004), systolic blood pressure (r = 0.28; P = 0.049), diastolic blood pressure (r = 0.44; P = 0.005), and HOMA-IR (r = 0.42; P = 0.005) levels in the entire diabetic subjects. In the diabetic patients group, presence of microalbuminuria was associated with a higher plasma IMA level (0.355 ± 0.035 and 0.265 ± 0.0045 AbsU; P < 0.0001, patients with microalbuminuria and control subjects, respectively). In the type 2 diabetes patients with nephropathy, IMA level (0.355 ± 0.035 and 0.311 ± 0.046 AbsU; P = 0.002) was determined higher compared to the diabetes patients without nephropathy. Diabetic patients without an overt cardiovascular disease still have a higher serum IMA level compared to healthy controls. The correlation of high plasma IMA levels with high hsCRP and microalbuminuria levels in diabetic subjects indicates the presence of a chronic ischemic process. Therefore, elevated IMA levels may indicate an underlying subclinical vascular disease in type 2 diabetes mellitus patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. P. Libby, Circulation 91, 2844–2850 (1995)

    CAS  PubMed  Google Scholar 

  2. P. Libby, P.M. Ridker, Circulation 100, 1148–1150 (1999)

    CAS  PubMed  Google Scholar 

  3. R. Ross, N. Engl. J. Med. 340, 115–126 (1999)

    Article  CAS  PubMed  Google Scholar 

  4. F.B. Hu, M.J. Stampfer, S.M. Haffner, C.G. Solomon, W.C. Willett, J.E. Manson, Diabetes Care 25, 1129–1134 (2002)

    Article  PubMed  Google Scholar 

  5. J.J. de, J.M. Dekker, A. Kooy, P.J. Kostense, G. Nijpels, R.J. Heine, L.M. Bouter, C.D. Stehouwer, Arterioscler. Thromb. Vasc. Biol. 26, 1086–1093 (2006)

    Article  Google Scholar 

  6. C.E. Mogensen, P.L. Poulsen, Curr. Opin. Nephrol. Hypertens. 3, 248–256 (1994)

    Article  CAS  PubMed  Google Scholar 

  7. F. Perticone, R. Ceravolo, A. Pujia, G. Ventura, S. Iacopino, A. Scozzafava, A. Ferraro, M. Chello, P. Mastroroberto, P. Verdecchia, G. Schillaci, Circulation 104, 191–196 (2001)

    CAS  PubMed  Google Scholar 

  8. N. Rifai, P.M. Ridker, Clin. Chem. 47, 403–411 (2001)

    CAS  PubMed  Google Scholar 

  9. P.J. Sadler, A. Tucker, J.H. Viles, Eur J. Biochem. 220, 193–200 (1994)

    Article  CAS  PubMed  Google Scholar 

  10. P.O. Collinson, D.C. Gaze, J. Clin. Pathol. 61, 1025–1028 (2008)

    Article  CAS  PubMed  Google Scholar 

  11. J. Dusek, J. St’asek, M. Tichy, J. Bis, J. Gregor, J. Vojacek, V. Masin, P. Polansky, M. Brtko, D. Cernohorsky, Clin. Chim. Acta. 367, 77–80 (2006)

    Article  CAS  PubMed  Google Scholar 

  12. H. Abboud, J. Labreuche, E. Meseguer, P.C. Lavallee, O. Simon, J.M. Olivot, M. Mazighi, M. Dehoux, J. Benessiano, P.G. Steg, P. Amarenco, Cerebrovasc. Dis. 23, 216–220 (2007)

    Article  CAS  PubMed  Google Scholar 

  13. R. Sharma, D.C. Gaze, D. Pellerin, R.L. Mehta, H. Gregson, C.P. Streather, P.O. Collinson, S.J. Brecker, Am. J. Kidney Dis. 47, 493–502 (2006)

    Article  CAS  PubMed  Google Scholar 

  14. R. Sharma, D.C. Gaze, D. Pellerin, R.L. Mehta, H. Gregson, C.P. Streather, P.O. Collinson, S.J. Brecker, Clin. Sci. (Lond.) 113, 25–32 (2007)

    Article  CAS  Google Scholar 

  15. S. Turedi, A. Gunduz, A. Mentese, S.C. Karahan, S.E. Yilmaz, O. Eroglu, I. Nuhoglu, I. Turan, M. Topbas, Am. J. Emerg. Med. 25, 770–773 (2007)

    Article  PubMed  Google Scholar 

  16. D. Borderie, Y. Allanore, C. Meune, J.Y. Devaux, O.G. Ekindjian, A. Kahan, Clin. Chem. 50, 2190–2193 (2004)

    Article  CAS  PubMed  Google Scholar 

  17. M. Senes, N. Kazan, O. Coskun, O. Zengi, L. Inan, D. Yucel, Ann. Clin. Biochem. 44, 43–47 (2007)

    Article  CAS  PubMed  Google Scholar 

  18. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, R.C. Turner, Diabetologia 28, 412–419 (1985)

    Article  CAS  PubMed  Google Scholar 

  19. D. Bar-Or, E. Lau, J.V. Winkler, J. Emerg. Med. 19, 311–315 (2000)

    Article  CAS  PubMed  Google Scholar 

  20. S. Turedi, A. Gunduz, A. Mentese, B. Dasdibi, S.C. Karahan, A. Sahin, G. Tuten, M. Kopuz, A. Alver, J. Resusc. doi:10.1016/j.resuscitation.2009.06.007

  21. M. Kalousova, A. Zak, J. Soukupova, S. Stipek, I.M. Malbohan, T. Zima, Cas. Lek. Cesk. 144, 385–389 (2005)

    CAS  PubMed  Google Scholar 

  22. E.R. Stadtman, B.S. Berlett, Drug Metab. Rev. 30, 225–243 (1998)

    Article  CAS  PubMed  Google Scholar 

  23. S.C. Satchell, J.E. Tooke, Diabetologia 51, 714–725 (2008)

    Article  CAS  PubMed  Google Scholar 

  24. T. Munzel, C. Sinning, F. Post, A. Warnholtz, E. Schulz, Ann. Med. 40, 180–196 (2008)

    Article  PubMed  Google Scholar 

  25. G. Lippi, M. Montagnana, G.C. Guidi, Int. J. Cardiol. 108, 410–411 (2006)

    Article  PubMed  Google Scholar 

  26. A. Piwowar, M. Knapik-Kordecka, M. Warwas, Dis. Markers 24, 311–317 (2008)

    CAS  PubMed  Google Scholar 

  27. P.M. Ridker, E. Danielson, F.A. Fonseca, J. Genest, A.M. Gotto Jr., J.J. Kastelein, W. Koenig, P. Libby, A.J. Lorenzatti, J.G. Macfadyen, B.G. Nordestgaard, J. Shepherd, J.T. Willerson, R.J. Glynn, N. Engl. J. Med. 359, 2195–2207 (2008)

    Article  CAS  PubMed  Google Scholar 

  28. A.S. Ametov, T.I. Demidova, S.A. Kosykh, Klin. Med. (Mosk) 83, 62–68 (2005)

    CAS  Google Scholar 

  29. J.A. Suwaidi, S. Hamasaki, S.T. Higano, R.A. Nishimura, D.R. Holmes Jr., A. Lerman, Circulation 101, 948–954 (2000)

    CAS  PubMed  Google Scholar 

Download references

Acknowledgments

Part of this study was presented in 41st Annual Meeting of EASD (Athens–2005) printed as an abstract in Diabetologia 48(S1): A409;2005.

Author information

Authors and Affiliations

  1. Canakkale Onsekiz Mart Universitesi, Tip Fakultesi, Endokrinoloji ve Metabolizma Hastaliklari BD, 17100, Çanakkale, Turkey

    Kubilay Ukinc

  2. Department of Biochemistry, Karadeniz Technical University, Trabzon, Turkey

    Selcuk Eminagaoglu & Caner Karahan

  3. Department of Endocrinology and Metabolism, Karadeniz Technical University, Trabzon, Turkey

    Halil Onder Ersoz, Cihangir Erem, Arif Bayram Hacihasanoglu & Mustafa Kocak

Authors
  1. Kubilay Ukinc
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Selcuk Eminagaoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Halil Onder Ersoz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Cihangir Erem
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Caner Karahan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Arif Bayram Hacihasanoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mustafa Kocak
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kubilay Ukinc.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ukinc, K., Eminagaoglu, S., Ersoz, H.O. et al. A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin. Endocr 36, 425–432 (2009). https://doi.org/10.1007/s12020-009-9236-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-009-9236-5

Keywords

Search

Navigation