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Novel antioxidants in anthracycline cardiotoxicity

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Abstract

It has been suggested nitroxides and their amine precursors prevent incidence of damage caused by superoxide and hydroxyl radicals formed during the oxidative metabolism of doxorubicin (DOX) and daunorubicin (DAU). Both doxorubicin and daunorubicin have been associated with cardiac toxicity in both adults and children. The authors herein suggest that cardioprotective molecules modified by nitroxides and their secondary amine precursors can prevent or diminish the anthracycline-induced cardiomyopathy by accumulating in cardiomiocytes.

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Acknowledgment

This work was supported Hungarian National Research Fund OTKAT048334 and OTKA T042951.

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Authors and Affiliations

  1. Department of Organic and Medicinal Chemistry, University of Pécs, P.O. Box 99, 7602, Pecs, Hungary

    Kálmán Hideg & Tamás Kálai

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  1. Kálmán Hideg
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  2. Tamás Kálai
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Correspondence to Kálmán Hideg.

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Hideg, K., Kálai, T. Novel antioxidants in anthracycline cardiotoxicity. Cardiovasc Toxicol 7, 160–164 (2007). https://doi.org/10.1007/s12012-007-0019-z

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