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Orthopaedic Case of the Month: Recurrent Thigh Pain in a 44-Year-Old Man

  • Orthopaedic Case of the Month
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Clinical Orthopaedics and Related Research®

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References

  1. Akin C, Metcalfe DD. Systemic mastocytosis. Annu Rev Med. 2004;55:419–432.

    Article  PubMed  CAS  Google Scholar 

  2. Austen KF. Systemic mastocytosis. (Comment on N Engl J Med. 1992;32:619–623.) N Engl J Med. 1992;326:639–640.

  3. Azouz EM, Saigal G, Rodriguez MM, Podda A. Langerhans’ cell histiocytosis: pathology, imaging and treatment of skeletal involvement. Pediatr Radiol. 2005;35:103–115.

    Article  PubMed  Google Scholar 

  4. Barete S, Assous N, de Gennes C, Grandpeix C, Feger F, Palmerini F, Dubreuil P, Arock M, Roux C, Launay JM, Fraitag S, Canioni D, Billemont B, Suarez F, Lanternier F, Lortholary O, Hermine O, Frances C. Systemic mastocytosis and bone involvement in a cohort of 75 patients. Ann Rheum Dis. 2010;69:1838–1841.

    Article  PubMed  CAS  Google Scholar 

  5. Castells M, Austen KF. Mastocytosis: mediator-related signs and symptoms. Int Arch Allergy Immunol. 2002;127:147–152.

    Article  PubMed  CAS  Google Scholar 

  6. Castells MC. Extracutaneous mastocytoma. J Allergy Clin Immunol. 2006;117:1513–1515.

    Article  PubMed  Google Scholar 

  7. Chen CC, Andrich MP, Mican JM, Metcalfe DD. A retrospective analysis of bone scan abnormalities in mastocytosis: correlation with disease category and prognosis. J Nucl Med. 1994;35:1471–1475.

    PubMed  CAS  Google Scholar 

  8. Chua SC, O’Connor SR, Wong WL, Ganatra RH. Case report: solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature. Br J Radiol. 2008;81:e110–e114.

    Article  PubMed  CAS  Google Scholar 

  9. Delsignore JL, Dvoretsky PM, Hicks DG, O’Keefe RJ, Rosier RN. Mastocytosis presenting as a skeletal disorder. Iowa Orthop J. 1996;16:126–134.

    PubMed  CAS  Google Scholar 

  10. Garcia-Montero AC, Jara-Acevedo M, Teodosio C, Sanchez ML, Nunez R, Prados A, Aldanondo I, Sanchez L, Dominguez M, Botana LM, Sachez-Jimenez F, Sotlar K, Almeida J, Escribano L, Orfao A. KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood. 2006;108:2366–2372.

    Article  PubMed  CAS  Google Scholar 

  11. Gibson PC, Cooper K. CD117 (KIT): a diverse protein with selective applications in surgical pathology. Adv Anat Pathol. 2002;9:65–69.

    Article  PubMed  Google Scholar 

  12. Gitelis S, Wilkins R, Conrad EU 3rd. Benign bone tumors. J Bone Joint Surg Am. 1995;77:1756–1782.

    Google Scholar 

  13. Kluin-Nelemans HC, Jansen JH, Breukelman H, Wolthers BG, Kluin PM, Kroon HM, Willemze R. Response to interferon alfa-2b in a patient with systemic mastocytosis. N Engl J Med. 1992;326:619–623.

    Article  PubMed  CAS  Google Scholar 

  14. Lewis VO. Hematologic malignancies. In: Damron TA, ed. Oncology and Basic Science (Orthopaedic Surgery Essentials). Philadelphia, PA: Lippincott Williams and Wilkins; 2008:244–250.

    Google Scholar 

  15. Patnaik MM, Rindos M, Kouides PA, Tefferi A, Pardanani A. Systemic mastocytosis: a concise clinical and laboratory review. Arch Pathol Lab Med. 2007;131:784–791.

    PubMed  Google Scholar 

  16. Patterson FR, Rooney MT, Damron TA, Vermont AI, Hutchison RE. Sclerotic lesion of the tibia without involvement of lymph nodes: report of an unusual case of Rosai-Dorfman disease. J Bone Joint Surg Am. 1997; 79:911–916.

    PubMed  CAS  Google Scholar 

  17. Shih HN, Shih LY, Wong YC. Diagnosis and treatment of subacute osteomyelitis. J Trauma. 2005;58:83–87.

    Article  PubMed  Google Scholar 

  18. Shih LY, Dunn P, Leung WM, Chen WJ, Wang PN. Localised plasmacytomas in Taiwan: comparison between extramedullary plasmacytoma and solitary plasmacytoma of bone. Br J Cancer. 1995;71:128–133.

    Article  PubMed  CAS  Google Scholar 

  19. Shulman S, Katzenstein H, Abramowsky C, Broecker J, Wulkan M, Shehata B. Unusual presentation of Rosai-Dorfman disease (RDD) in the bone in adolescents. Fetal Pediatr Pathol. 2011;30:442–447.

    Article  PubMed  Google Scholar 

  20. Simpson JK, Metcalfe DD. Mastocytosis and disorders of mast cell proliferation. Clin Rev Allergy Immunol. 2002;22:175–188.

    Article  PubMed  Google Scholar 

  21. Travis WD, Li CY, Bergstralh EJ, Yam LT, Swee RG. Systemic mast cell disease: analysis of 58 cases and literature review. Medicine (Baltimore). 1988;67:345–368.

    CAS  Google Scholar 

  22. Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB, Marone G, Nunez R, Akin C, Sotlar K, Sperr WR, Wolff K, Brunning RD, Parwaresch RM, Austen KF, Lennert K, Metcalfe DD, Vardiman JW, Bennett JM. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res. 2001;25:603–625.

    Article  PubMed  CAS  Google Scholar 

  23. Valent P, Spanblöchl E, Sperr WR, Sillaber C, Zsebo KM, Agis H, Strobl H, Geissler K, Bettelheim P, Lechner K. Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture. Blood. 1992;80:2237–2245.

    PubMed  CAS  Google Scholar 

  24. Vega F, Chang CC, Medeiros LJ, Udden MM, Cho-Vega JH, Lau CC, Finch CJ, Vilchez RA, McGregor D, Jorgensen JL. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol. 2005;18:806–815.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, University of Cincinnati, Cincinnati, OH, USA

    Adam O. Burzynski MD

  2. Department of Pathology, Upstate Medical University, Syracuse, NY, USA

    Alfredo Luis Valente MD

  3. Department of Orthopaedic Surgery, Upstate Medical University, 4400 University Hospital, 750 East Adams Street, Syracuse, NY, 13210, USA

    Timothy A. Damron MD

Authors
  1. Adam O. Burzynski MD
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  2. Alfredo Luis Valente MD
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  3. Timothy A. Damron MD
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Corresponding author

Correspondence to Timothy A. Damron MD.

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Each author certifies that he or she, or a member of his or her immediate family, has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request.

Each author certifies that his or her institution approved the reporting of this case report, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.

This work was performed at Upstate Medical University.

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Burzynski, A.O., Valente, A.L. & Damron, T.A. Orthopaedic Case of the Month: Recurrent Thigh Pain in a 44-Year-Old Man. Clin Orthop Relat Res 470, 2339–2344 (2012). https://doi.org/10.1007/s11999-012-2361-0

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  • DOI: https://doi.org/10.1007/s11999-012-2361-0

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