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Update: Modern Approaches to the Treatment of Localized Esophageal Cancer

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Abstract

The optimal treatment strategy for esophageal cancer continues to be a topic of debate. Improvements in chemotherapy drugs, surgical techniques, and radiotherapy planning and delivery have led to the design of treatment approaches that are specific to both the stage of the tumor and the overall performance status of the patient. Surgery continues to be the standard treatment option for localized disease, but multimodality treatments that include radiation and chemotherapy with surgery are increasingly used. The next few years will continue to see improvements in radiation techniques, especially proton beam treatment; the development of additional minimally invasive surgical approaches to minimize postoperative side effects; and the discovery of molecular biomarkers to help specifically target treatment of esophageal cancer in individual patients.

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Authors and Affiliations

  1. Division of Radiation Oncology, Unit 97, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    James Welsh, Anna Likhacheva, Ritsuko Komaki & Zhongxing Liao

  2. University of California, Irvine, University Drive, Irvine, CA, 92697, USA

    Arya Amini

  3. Department of Diagnostic Radiology, Unit 1478, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Jeremy Erasmus J.

  4. Department of Radiation Oncology, Unit 1150, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Daniel Gomez

  5. Department of Gastroenterology, Hepatology, and Nutrition, Unit 1466, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Marta Davila, Jeffrey Lee H. & Manoop S. Bhutani

  6. Department of Thoracic and Cardiovascular Surgery, Unit 1489, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Reza J. Mehran & Wayne L. Hofstetter

  7. Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Jaffer A. Ajani

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  1. James Welsh
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  2. Arya Amini
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  3. Anna Likhacheva
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  4. Jeremy Erasmus J.
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  5. Daniel Gomez
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  7. Reza J. Mehran
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  9. Zhongxing Liao
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  10. Wayne L. Hofstetter
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  11. Jeffrey Lee H.
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  13. Jaffer A. Ajani
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Correspondence to James Welsh.

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Welsh, J., Amini, A., Likhacheva, A. et al. Update: Modern Approaches to the Treatment of Localized Esophageal Cancer. Curr Oncol Rep 13, 157–167 (2011). https://doi.org/10.1007/s11912-011-0158-z

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