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Lenalidomide: Immunomodulatory, antiangiogenic, and clinical activity in solid tumors

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Abstract

Lenalidomide is a novel analog of thalidomide with both immunomodulatory and antiangiogenic properties that are more potent than those same properties in the parent compound. Work in several antiangiogenic model systems has provided early evidence of potential mechanisms of its clinical activity. Recent US Food and Drug Administration approval of lenalidomide for patients with deletion 5q myelodysplastic syndromes and advanced multiple myeloma has provided impetus for further evaluation of this agent in solid tumors.

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Authors and Affiliations

  1. Department of Solid Tumor Oncology, Taussig Cancer Center, The Cleveland Clinic Foundation, 9500 Euclid Avenue, R35, Cleveland, OH, 44195, USA

    Robert Dreicer MD

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  1. Robert Dreicer MD
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Correspondence to Robert Dreicer MD.

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Dreicer, R. Lenalidomide: Immunomodulatory, antiangiogenic, and clinical activity in solid tumors. Curr Oncol Rep 9, 120–123 (2007). https://doi.org/10.1007/s11912-007-0008-1

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  • DOI: https://doi.org/10.1007/s11912-007-0008-1

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