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Pathophysiology of restless legs syndrome: Evidence for iron involvement

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Abstract

Neuroimaging, analysis of cerebrospinal fluid, and studies on postmortem tissue are generating data that support the concept that iron availability to the brain is a contributory process to, if not a cause of, restless legs syndrome. These data are reviewed and related to the dopaminergic system because of the use of dopamine agents in treating restless legs syndrome.

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Authors and Affiliations

  1. G.M. Leader Family Laboratory, Department of Neurosurgery, Pennsylvania State University, Milton S. Hershey Medical Center, 500 University Drive, PO Box 850, Hershey, PA, 17033, USA

    James R. Connor

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  1. James R. Connor
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Correspondence to James R. Connor.

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Connor, J.R. Pathophysiology of restless legs syndrome: Evidence for iron involvement. Curr Neurol Neurosci Rep 8, 162–166 (2008). https://doi.org/10.1007/s11910-008-0026-x

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