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Bacterial Infections of the Central Nervous System

  • CENTRAL NERVOUS SYSTEM (J LYONS, SECTION EDITOR)
  • Published:
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Abstract

Bacterial CNS infections comprise a wide spectrum of diseases, which may be acquired outside or inside the hospital, affect immunocompetent or immunocompromised patients, and be associated with trauma or procedures, as well as other exposures.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Kramer AH, Bleck TP. Neurocritical care of patients with central nervous system infections. Curr Infect Dis Rep. 2007;9(4):308–14.

    PubMed  Google Scholar 

  2. Diringer MN, Reaven NL, Funk SE, Uman GC. Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med. 2004;32(7):1489–95.

    PubMed  Google Scholar 

  3. Tunkel AR, Scheld WM. Acute meningitis. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. Philadelphia: Elsevier; 2005. p. 1083–126.

    Google Scholar 

  4. Diringer MN, Zazulia AR. Osmotic therapy: fact and fiction. Neurocrit Care. 2004;1(2):219–33.

    PubMed  CAS  Google Scholar 

  5. Angstwurm K, Reuss S, Freyer D, et al. Induced hypothermia in experimental pneumococcal meningitis. J Cereb Blood Flow Metab. 2000;20(5):834–8.

    PubMed  CAS  Google Scholar 

  6. Cuthbertson BH, Dickson R, Mackenzie A. Intracranial pressure measurement, induced hypothermia and barbiturate coma in meningitis associated with intractable raised intracranial pressure. Anaesthesia. 2004;59(9):908–11.

    PubMed  CAS  Google Scholar 

  7. Schwab S, Junger E, Spranger M, et al. Craniectomy: an aggressive treatment approach in severe encephalitis. Neurology. 1997;48(2):412–7.

    PubMed  CAS  Google Scholar 

  8. Claassen J, Mayer SA, Kowalski RG, et al. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62(10):1743–8.

    PubMed  CAS  Google Scholar 

  9. Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children: a meta-analysis. Pediatr Infect Dis J. 1993;12(5):389–94.

    PubMed  CAS  Google Scholar 

  10. Grimwood K, Anderson P, Anderson V, et al. Twelve year outcomes following bacterial meningitis: further evidence for persisting effects. Arch Dis Child. 2000;83(2):111–6.

    PubMed  CAS  Google Scholar 

  11. Short WR, Tunkel AR. Changing epidemiology of bacterial meningitis in the United States. Curr Infect Dis Rep. 2000;2(4):327–31.

    PubMed  Google Scholar 

  12. van de Beek D, de Gans J, Tunkel AR, Wijdicks EF. Community-acquired bacterial meningitis in adults. N Engl J Med. 2006;354(1):44–53.

    PubMed  Google Scholar 

  13. van de Beek D, de Gans J, Spanjaard L, et al. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004;351(18):1849–59.

    PubMed  Google Scholar 

  14. •• Thigpen MC, Whitney CG, Messonnier NE, et al. Bacterial meningitis in the United States, 1998–2007. N Engl J Med. 2011;364(21):2016–25. This article provides an updated overview over epidemiology and pathogens of bacterial meningitis in the US over the past decade.

  15. Quagliarello V, Scheld WM. Bacterial meningitis: pathogenesis, pathophysiology, and progress. N Engl J Med. 1992;327(12):864–72.

    PubMed  CAS  Google Scholar 

  16. Tunkel AR. Bacterial meningitis. Philadelphia: Williams & Wilkins; 2001.

    Google Scholar 

  17. Grandgirard D, Leib SL. Strategies to prevent neuronal damage in paediatric bacterial meningitis. Curr Opin Pediatr. 2006;18(2):112–8.

    PubMed  Google Scholar 

  18. Curtis S, Stobart K, Vandermeer B, et al. Clinical features suggestive of meningitis in children: a systematic review of prospective data. Pediatrics. 2010;126(5):952–60.

    PubMed  Google Scholar 

  19. Flores-Cordero JM, Amaya-Villar R, Rincón-Ferrari MD, et al. Acute community-acquired bacterial meningitis in adults admitted to the intensive care unit: clinical manifestations, management and prognostic factors. Intensive Care Med. 2003;29(11):1967–73.

    PubMed  Google Scholar 

  20. Wang KW, Chang WN, Chang HW, et al. The significance of seizures and other predictive factors during the acute illness for the long-term outcome after bacterial meningitis. Seizure. 2005;14(8):586–92.

    PubMed  Google Scholar 

  21. Wang KW, Chang WN, Chang HW, et al. Clinical relevance of hydrocephalus in bacterial meningitis in adults. Surg Neurol. 2005;64(1):61–5. discussion 66.

    PubMed  Google Scholar 

  22. Weisfelt M, van de Beek D, Spanjaard L, et al. Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol. 2006;5(2):123–9.

    PubMed  Google Scholar 

  23. • Jim KK, Brouwer MC, van der Ende A, van de Beek D. Cerebral abscesses in patients with bacterial meningitis. J Infect. 2012;64(2):236–8. In this article, the most recent comprehensive analysis of features and occurrence of brain abscess in the setting of bacterial meningitis can be reviewed.

  24. Bhimraj A. Acute community-acquired bacterial meningitis in adults: an evidence-based review. Cleve Clin J Med. 2012;79(6):393–400.

    PubMed  Google Scholar 

  25. Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev. 2010;23(3):467–92.

    PubMed  CAS  Google Scholar 

  26. Michael B, Menezes BF, Cunniffe J, et al. Effect of delayed lumbar punctures on the diagnosis of acute bacterial meningitis in adults. Emerg Med J. 2010;27(6):433–8.

    PubMed  Google Scholar 

  27. Durand ML, Calderwood SB, Weber DJ, et al. Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med. 1993;328(1):21–8.

    PubMed  CAS  Google Scholar 

  28. Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39(9):1267–84.

    PubMed  Google Scholar 

  29. Huy NT, Thao NT, Diep DT, et al. Cerebrospinal fluid lactate concentration to distinguish bacterial from aseptic meningitis: a systemic review and meta-analysis. Crit Care. 2010;14(6):R240.

    PubMed  Google Scholar 

  30. • Sakushima K, Hayashino Y, Kawaguchi T, et al. Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis. J Infect. 2011;62(4):255–62. This article offers a comprehensive analysis and review of data available regarding laboratory distinction of different forms of meningitis by testing CSF lactate.

  31. Brouwer MC, Thwaites GE, Tunkel AR, van de Beek D. Dilemmas in the diagnosis of acute community-acquired bacterial meningitis. Lancet. 2012;380(9854):1684–92.

    PubMed  Google Scholar 

  32. Linder A, Akesson P, Brink M, et al. Heparin-binding protein: a diagnostic marker of acute bacterial meningitis. Crit Care Med. 2011;39(4):812–7.

    PubMed  CAS  Google Scholar 

  33. Stahel PF, Nadal D, Pfister HW, et al. Complement C3 and factor B cerebrospinal fluid concentrations in bacterial and aseptic meningitis. Lancet. 1997;349(9069):1886–7.

    PubMed  CAS  Google Scholar 

  34. Dubos F, Korczowski B, Aygun DA, et al. Serum procalcitonin level and other biological markers to distinguish between bacterial and aseptic meningitis in children: a European multicenter case cohort study. Arch Pediatr Adolesc Med. 2008;162(12):1157–63.

    PubMed  Google Scholar 

  35. Proulx N, Frechette D, Toye B, et al. Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis. QJM. 2005;98(4):291–8.

    PubMed  CAS  Google Scholar 

  36. Auburtin M, Wolff M, Charpentier J, et al. Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. Crit Care Med. 2006;34(11):2758–65.

    PubMed  CAS  Google Scholar 

  37. de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002;347(20):1549–56.

    PubMed  Google Scholar 

  38. van de Beek D, Farrar JJ, de Gans J, et al. Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. Lancet Neurol. 2010;9(3):254–63.

    PubMed  Google Scholar 

  39. Assiri AM, Alasmari FA, Zimmerman VA, et al. Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: a meta-analysis. Mayo Clin Proc. 2009;84(5):403–9.

    PubMed  CAS  Google Scholar 

  40. Vardakas KZ, Matthaiou DK, Falagas ME. Adjunctive dexamethasone therapy for bacterial meningitis in adults: a meta-analysis of randomized controlled trials. Eur J Neurol. 2009;16(6):662–73.

    PubMed  CAS  Google Scholar 

  41. Lindvall P, Ahlm C, Ericsson M, et al. Reducing intracranial pressure may increase survival among patients with bacterial meningitis. Clin Infect Dis. 2004;38(3):384–90.

    PubMed  Google Scholar 

  42. McIntyre PB, O’Brien KL, Greenwood B, van de Beek D. Effect of vaccines on bacterial meningitis worldwide. Lancet. 2012;380(9854):1703–11.

    PubMed  Google Scholar 

  43. Baltas I, Tsoulfa S, Sakellariou P, et al. Posttraumatic meningitis: bacteriology, hydrocephalus, and outcome. Neurosurgery. 1994;35(3):422–6. discussion 426–7.

    PubMed  CAS  Google Scholar 

  44. Bullock MR, Chesnut R, Ghajar J, et al. Surgical management of depressed cranial fractures. Neurosurgery. 2006;58(3 Suppl):S56–60. discussion Si–iv.

    PubMed  Google Scholar 

  45. Tunkel AR, Turtz AR. Post-traumatic infections of the central nervous system. In: Evans RW, editor. Neurology and trauma. New York: Oxford Uniersity Press; 2006. p. 628–38.

    Google Scholar 

  46. van de Beek D, Drake JM, Tunkel AR. Nosocomial bacterial meningitis. N Engl J Med. 2010;362(2):146–54.

    PubMed  Google Scholar 

  47. Ratilal B, Costa J, Sampaio C, Pappamikail L. Antibiotic prophylaxis for preventing meningitis in patients with basilar skull fractures. Cochrane Database of Systematic Reviews 2011, Issue 8. Art. No.: CD004884. doi:10.1002/14651858.CD004884.pub3.

  48. Mathisen GE, Johnson JP. Brain abscess. Clin Infect Dis. 1997;25(4):763–79. quiz 780–1.

    PubMed  CAS  Google Scholar 

  49. Nathoo N, Nadvi SS, Narotam PK, van Dellen JR. Brain abscess: management and outcome analysis of a computed tomography era experience with 973 patients. World Neurosurg. 2011;75(5–6):716–26. discussion 612–7.

    PubMed  Google Scholar 

  50. Tsou TP, Lee PI, Lu CY, et al. Microbiology and epidemiology of brain abscess and subdural empyema in a medical center: a 10-year experience. J Microbiol Immunol Infect. 2009;42(5):405–12.

    PubMed  Google Scholar 

  51. Gadgil N, Chamoun RB, Gopinath SP. Intraventricular brain abscess. J Clin Neurosci. 2012;19(9):1314–6.

    PubMed  Google Scholar 

  52. Lambo A, Nchimi A, Khamis J, et al. Primary intraventricular brain abscess. Neuroradiology. 2003;45(12):908–10.

    PubMed  CAS  Google Scholar 

  53. Manzar N, Manzar B, Kumar R, Bari ME. The study of etiologic and demographic characteristics of intracranial brain abscess: a consecutive case series study from Pakistan. World Neurosurg. 2011;76(1–2):195–200. discussion 79–83.

    PubMed  Google Scholar 

  54. Carpenter J, Stapleton S, Holliman R. Retrospective analysis of 49 cases of brain abscess and review of the literature. Eur J Clin Microbiol Infect Dis. 2007;26(1):1–11.

    PubMed  CAS  Google Scholar 

  55. Xiao F, Tseng MY, Teng LJ, et al. Brain abscess: clinical experience and analysis of prognostic factors. Surg Neurol. 2005;63(5):442–9. discussion 449–50.

    PubMed  Google Scholar 

  56. Mampalam TJ, Rosenblum ML. Trends in the management of bacterial brain abscesses: a review of 102 cases over 17 years. Neurosurgery. 1988;23(4):451–8.

    PubMed  CAS  Google Scholar 

  57. • Arlotti M, Grossi P, Pea F, et al. Consensus document on controversial issues for the treatment of infections of the central nervous system: bacterial brain abscesses. Int J Infect Dis. 2010;14 Suppl 4:S79–92. This article provides a consensus guideline approach to the topic of treatment of brain abscess.

  58. Bayston R, de Louvois J, Brown EM, et al. Use of antibiotics in penetrating craniocerebral injuries. Infection in Neurosurgery Working Party of British Society for Antimicrobial Chemotherapy. Lancet. 2000;355(9217):1813–7.

    PubMed  CAS  Google Scholar 

  59. Lee TH, Chang WN, Su TM, et al. Clinical features and predictive factors of intraventricular rupture in patients who have bacterial brain abscesses. J Neurol Neurosurg Psychiatry. 2007;78(3):303–9.

    PubMed  Google Scholar 

  60. Kourbeti IS, Jacobs AV, Koslow M, et al. Risk factors associated with postcraniotomy meningitis. Neurosurgery. 2007;60(2):317–25. discussion 325–6.

    PubMed  Google Scholar 

  61. McClelland 3rd S, Hall WA. Postoperative central nervous system infection: incidence and associated factors in 2111 neurosurgical procedures. Clin Infect Dis. 2007;45(1):55–9.

    PubMed  Google Scholar 

  62. Korinek AM, Baugnon T, Golmard JL, et al. Risk factors for adult nosocomial meningitis after craniotomy: role of antibiotic prophylaxis. Neurosurgery. 2006;59(1):126–33. discussion 126–33.

    PubMed  Google Scholar 

  63. Leib SL, Boscacci R, Gratzl O, Zimmerli W. Predictive value of cerebrospinal fluid (CSF) lactate level versus CSF/blood glucose ratio for the diagnosis of bacterial meningitis following neurosurgery. Clin Infect Dis. 1999;29(1):69–74.

    PubMed  CAS  Google Scholar 

  64. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52(3):e18–55.

    PubMed  Google Scholar 

  65. Lozier AP, Sciacca RR, Romagnoli MF, et al. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery. 2008;62 Suppl 2:688–700.

    PubMed  Google Scholar 

  66. Lozier AP, Sciacca RR, Romagnoli MF, Connolly Jr ES. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery. 2002;51(1):170–81. discussion 181–2.

    PubMed  Google Scholar 

  67. Lyke KE, Obasanjo OO, Williams MA, et al. Ventriculitis complicating use of intraventricular catheters in adult neurosurgical patients. Clin Infect Dis. 2001;33(12):2028–33.

    PubMed  CAS  Google Scholar 

  68. Mayhall CG, Archer NH, Lamb VA, et al. Ventriculostomy-related infections. A prospective epidemiologic study. N Engl J Med. 1984;310(9):553–9.

    PubMed  CAS  Google Scholar 

  69. Hoefnagel D, Dammers R, Ter Laak-Poort MP, et al. Risk factors for infections related to external ventricular drainage. Acta Neurochir (Wien). 2008;150(3):209–14. discussion 214.

    PubMed  CAS  Google Scholar 

  70. Chi H, Chang KY, Chang HC, et al. Infections associated with indwelling ventriculostomy catheters in a teaching hospital. Int J Infect Dis. 2010;14(3):e216–9.

    PubMed  Google Scholar 

  71. Tse T, Cheng K, Wong K, et al. Ventriculostomy and infection: a 4-year-review in a local hospital. Surg Neurol Int. 2010;1:47.

    PubMed  Google Scholar 

  72. Holloway KL, Barnes T, Choi S, et al. Ventriculostomy infections: the effect of monitoring duration and catheter exchange in 584 patients. J Neurosurg. 1996;85(3):419–24.

    PubMed  CAS  Google Scholar 

  73. Arabi Y, Memish ZA, Balkhy HH, et al. Ventriculostomy-associated infections: incidence and risk factors. Am J Infect Control. 2005;33(3):137–43.

    PubMed  Google Scholar 

  74. Stenehjem E, Armstrong WS. Central nervous system device infections. Infect Dis Clin North Am. 2012;26(1):89–110.

    PubMed  Google Scholar 

  75. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309–32.

    PubMed  Google Scholar 

  76. Ross D, Rosegay H, Pons V. Differentiation of aseptic and bacterial meningitis in postoperative neurosurgical patients. J Neurosurg. 1988;69(5):669–74.

    PubMed  CAS  Google Scholar 

  77. Schade RP, Schinkel J, Roelandse FW, et al. Lack of value of routine analysis of cerebrospinal fluid for prediction and diagnosis of external drainage-related bacterial meningitis. J Neurosurg. 2006;104(1):101–8.

    PubMed  Google Scholar 

  78. Pfausler B, Beer R, Engelhardt K, et al. Cell index – a new parameter for the early diagnosis of ventriculostomy (external ventricular drainage)-related ventriculitis in patients with intraventricular hemorrhage? Acta Neurochir (Wien). 2004;146(5):477–81.

    PubMed  CAS  Google Scholar 

  79. Wong GK, Poon WS, Ip M. Use of ventricular cerebrospinal fluid lactate measurement to diagnose cerebrospinal fluid infection in patients with intraventricular haemorrhage. J Clin Neurosci. 2008;15(6):654–5.

    PubMed  CAS  Google Scholar 

  80. Sundbarg G, Nordstrom CH, Söderström S. Complications due to prolonged ventricular fluid pressure recording. Br J Neurosurg. 1988;2(4):485–95.

    PubMed  CAS  Google Scholar 

  81. Camacho EF, Boszczowski I, Basso M, et al. Infection rate and risk factors associated with infections related to external ventricular drain. Infection. 2011;39(1):47–51.

    PubMed  CAS  Google Scholar 

  82. Scheithauer S, Burgel U, Bickenbach J, et al. External ventricular and lumbar drainage-associated meningoventriculitis: prospective analysis of time-dependent infection rates and risk factor analysis. Infection. 2010;38(3):205–9.

    PubMed  CAS  Google Scholar 

  83. Ntziora F, Falagas ME. Linezolid for the treatment of patients with central nervous system infection. Ann Pharmacother. 2007;41(2):296–308.

    PubMed  CAS  Google Scholar 

  84. Kethireddy S, Andes D. CNS pharmacokinetics of antifungal agents. Expert Opin Drug Metab Toxicol. 2007;3(4):573–81.

    PubMed  CAS  Google Scholar 

  85. Tangden T, Enblad P, Ullberg M, Sjölin J. Neurosurgical gram-negative bacillary ventriculitis and meningitis: a retrospective study evaluating the efficacy of intraventricular gentamicin therapy in 31 consecutive cases. Clin Infect Dis. 2011;52(11):1310–6.

    PubMed  Google Scholar 

  86. Elvy J, Porter D, Brown E. Treatment of external ventricular drain-associated ventriculitis caused by Enterococcus faecalis with intraventricular daptomycin. J Antimicrob Chemother. 2008;61(2):461–2.

    PubMed  CAS  Google Scholar 

  87. Kim BN, Peleg AY, Lodise TP, et al. Management of meningitis due to antibiotic-resistant Acinetobacter species. Lancet Infect Dis. 2009;9(4):245–55.

    PubMed  CAS  Google Scholar 

  88. Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49(1):1–45.

    PubMed  CAS  Google Scholar 

  89. Korinek AM, Fulla-Oller L, Boch AL, et al. Morbidity of ventricular cerebrospinal fluid shunt surgery in adults: an 8-year study. Neurosurgery. 2011;68(4):985–94. discussion 994–5.

    PubMed  Google Scholar 

  90. Conen A, Walti LN, Merlo A, et al. Characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period. Clin Infect Dis. 2008;47(1):73–82.

    PubMed  Google Scholar 

  91. Laxmi S, Tunkel AR. Healthcare-associated bacterial meningitis. Curr Infect Dis Rep. 2011;13(4):367–73.

    PubMed  Google Scholar 

  92. Whitehead WE, Kestle JR. The treatment of cerebrospinal fluid shunt infections. Results from a practice survey of the American Society of Pediatric Neurosurgeons. Pediatr Neurosurg. 2001;35(4):205–10.

    PubMed  CAS  Google Scholar 

  93. Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006;355(26):2725–32.

    PubMed  CAS  Google Scholar 

  94. •• Leverstein-van Hall MA, Hopmans TE, van der Sprenkel JW, et al. A bundle approach to reduce the incidence of external ventricular and lumbar drain-related infections. J Neurosurg. 2010;112(2):345–53. This article features the changes in occurrence of EVD related infections with introduction of infection control by using a bundle approach.

  95. Korinek AM, Reina M, Boch AL, et al. Prevention of external ventricular drain-related ventriculitis. Acta Neurochir (Wien). 2005;147(1):39–45. discussion 45–6.

    PubMed  Google Scholar 

  96. Alleyne Jr CH, Hassan M, Zabramski JM. The efficacy and cost of prophylactic and perioprocedural antibiotics in patients with external ventricular drains. Neurosurgery. 2000;47(5):1124–7. discussion 1127–9.

    PubMed  Google Scholar 

  97. Poon WS, Ng S, Wai S. CSF antibiotic prophylaxis for neurosurgical patients with ventriculostomy: a randomised study. Acta Neurochir Suppl. 1998;71:146–8.

    PubMed  CAS  Google Scholar 

  98. Ratilal B, Costa J, Sampaio C. Antibiotic prophylaxis for surgical introduction of intracranial ventricular shunts. Cochrane Database of Systematic Reviews 2006, Issue 3. Art. No.: CD005365. doi:10.1002/14651858.CD005365.pub2.

  99. Zabramski JM, Whiting D, Darouiche RO, et al. Efficacy of antimicrobial-impregnated external ventricular drain catheters: a prospective, randomized, controlled trial. J Neurosurg. 2003;98(4):725–30.

    PubMed  Google Scholar 

  100. Abla AA, Zabramski JM, Jahnke HK, et al. Comparison of two antibiotic-impregnated ventricular catheters: a prospective sequential series trial. Neurosurgery. 2011;68(2):437–42. discussion 442.

    PubMed  Google Scholar 

  101. Harrop JS, Sharan AD, Ratliff J, et al. Impact of a standardized protocol and antibiotic-impregnated catheters on ventriculostomy infection rates in cerebrovascular patients. Neurosurgery. 2010;67(1):187–91. discussion 191.

    PubMed  Google Scholar 

  102. Stevens EA, Palavecino E, Sherertz RJ, et al. Effects of antibiotic-impregnated external ventricular drains on bacterial culture results: an in vitro analysis. J Neurosurg. 2010;113(1):86–92.

    PubMed  Google Scholar 

  103. Fichtner J, Guresir E, Seifert V, Raabe A. Efficacy of silver-bearing external ventricular drainage catheters: a retrospective analysis. J Neurosurg. 2010;112(4):840–6.

    PubMed  Google Scholar 

  104. Baer ET. Post-dural puncture bacterial meningitis. Anesthesiology. 2006;105(2):381–93.

    PubMed  Google Scholar 

  105. Governale LS, Fein N, Logsdon J, Black PM. Techniques and complications of external lumbar drainage for normal pressure hydrocephalus. Neurosurgery. 2008;63(4 Suppl 2):379–84. discussion 384.

    PubMed  Google Scholar 

  106. Piek J, Bock WJ. Continuous monitoring of cerebral tissue pressure in neurosurgical practice – experiences with 100 patients. Intensive Care Med. 1990;16(3):184–8.

    PubMed  CAS  Google Scholar 

  107. Gelabert-Gonzalez M, Ginesta-Galan V, Sernamito-García R, et al. The Camino intracranial pressure device in clinical practice. Assessment in a 1000 cases. Acta Neurochir (Wien). 2006;148(4):435–41.

    PubMed  CAS  Google Scholar 

  108. Martinez-Manas RM, Santamarta D, de Campos JM, Ferrer E. Camino intracranial pressure monitor: prospective study of accuracy and complications. J Neurol Neurosurg Psychiatry. 2000;69(1):82–6.

    PubMed  CAS  Google Scholar 

  109. May AK, Fleming SB, Carpenter RO, et al. Influence of broad-spectrum antibiotic prophylaxis on intracranial pressure monitor infections and subsequent infectious complications in head-injured patients. Surg Infect (Larchmt). 2006;7(5):409–17.

    PubMed  Google Scholar 

  110. Poca MA, Sahuquillo J, Arribas M, et al. Fiberoptic intraparenchymal brain pressure monitoring with the Camino V420 monitor: reflections on our experience in 163 severely head-injured patients. J Neurotrauma. 2002;19(4):439–48.

    PubMed  Google Scholar 

  111. Shapiro S, Bowman R, Callahan J, Wolfla C. The fiberoptic intraparenchymal cerebral pressure monitor in 244 patients. Surg Neurol. 1996;45(3):278–82.

    PubMed  CAS  Google Scholar 

  112. Stoikes NF, Magnotti LJ, Hodges TM, et al. Impact of intracranial pressure monitor prophylaxis on central nervous system infections and bacterial multi-drug resistance. Surg Infect (Larchmt). 2008;9(5):503–8.

    PubMed  Google Scholar 

  113. Morton R, Lucas 2nd TH, Ko A, et al. Intracerebral abscess associated with the Camino intracranial pressure monitor: case report and review of the literature. Neurosurgery. 2012;71(1):E193–8.

    PubMed  Google Scholar 

  114. Fily F, Haegelen C, Tattevin P, et al. Deep brain stimulation hardware-related infections: a report of 12 cases and review of the literature. Clin Infect Dis. 2011;52(8):1020–3.

    PubMed  Google Scholar 

  115. Vergani F, Landi A, Pirillo D, et al. Surgical, medical, and hardware adverse events in a series of 141 patients undergoing subthalamic deep brain stimulation for Parkinson disease. World Neurosurg. 2010;73(4):338–44.

    PubMed  Google Scholar 

  116. Gorgulho A, Juillard C, Uslan DZ, et al. Infection following deep brain stimulator implantation performed in the conventional versus magnetic resonance imaging-equipped operating room. J Neurosurg. 2009;110(2):239–46.

    PubMed  Google Scholar 

  117. Anderson DJ, Kaye KS, Classen D, et al. Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29 Suppl 1:S51–61.

    PubMed  Google Scholar 

  118. Zuger A. Tuberculosis. In: Scheld WM, Whitley RJ, Marra CM, editors. Infections of the central nervous system. Philadelphia: Lippincott Williams & Wilkins; 2004. p. 441–60.

    Google Scholar 

  119. Chatterjee S. Brain tuberculomas, tubercular meningitis, and post-tubercular hydrocephalus in children. J Pediatr Neurosci. 2011;6 Suppl 1:S96–S100.

    PubMed  Google Scholar 

  120. Pehlivanoglu F, Yasar KK, Sengoz G. Tuberculous meningitis in adults: a review of 160 cases. ScientificWorldJournal. 2012;2012:169028.

    PubMed  Google Scholar 

  121. Kalita J, Misra UK, Ranjan P. Predictors of long-term neurological sequelae of tuberculous meningitis: a multivariate analysis. Eur J Neurol. 2007;14(1):33–7.

    PubMed  CAS  Google Scholar 

  122. Sinner SW. Approach to the diagnosis and management of tuberculous meningitis. Curr Infect Dis Rep. 2010;12(4):291–8.

    PubMed  Google Scholar 

  123. Moghtaderi A, Alavi-Naini R, Izadi S, Cuevas LE. Diagnostic risk factors to differentiate tuberculous and acute bacterial meningitis. Scand J Infect Dis. 2009;41(3):188–94.

    PubMed  Google Scholar 

  124. Katrak SM, Shembalkar PK, Bijwe SR, Bhandarkar LD. The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection. J Neurol Sci. 2000;181(1–2):118–26.

    PubMed  CAS  Google Scholar 

  125. Lammie GA, Hewlett RH, Schoeman JF, Donald PR. Tuberculous cerebrovascular disease: a review. J Infect. 2009;59(3):156–66.

    PubMed  Google Scholar 

  126. Kalita J, Misra UK, Nair PP. Predictors of stroke and its significance in the outcome of tuberculous meningitis. J Stroke Cerebrovasc Dis. 2009;18(4):251–8.

    PubMed  Google Scholar 

  127. Thwaites GE, Chau TT, Stepniewska K, et al. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet. 2002;360(9342):1287–92.

    PubMed  CAS  Google Scholar 

  128. Katti MK. Pathogenesis, diagnosis, treatment, and outcome aspects of cerebral tuberculosis. Med Sci Monit. 2004;10(9):RA215–29.

    PubMed  Google Scholar 

  129. Rafi W, Venkataswamy MM, Nagarathna S, et al. Role of IS6110 uniplex PCR in the diagnosis of tuberculous meningitis: experience at a tertiary neurocentre. Int J Tuberc Lung Dis. 2007;11(2):209–14.

    PubMed  CAS  Google Scholar 

  130. Pai M, Flores LL, Pai N, et al. Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 2003;3(10):633–43.

    PubMed  CAS  Google Scholar 

  131. Wasay M, Kheleani BA, Moolani MK, et al. Brain CT and MRI findings in 100 consecutive patients with intracranial tuberculoma. J Neuroimaging. 2003;13(3):240–7.

    PubMed  Google Scholar 

  132. Thwaites GE, Tran TH. Tuberculous meningitis: many questions, too few answers. Lancet Neurol. 2005;4(3):160–70.

    PubMed  Google Scholar 

  133. American Thoracic Society; CDC; Infectious Diseases Society of America. Treatment of tuberculosis. MMWR Recomm Rep. 2003;52(RR-11):1–77.

    Google Scholar 

  134. Blumberg HM, Burman WJ, Chaisson RE, et al. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med. 2003;167(4):603–62.

    PubMed  Google Scholar 

  135. Takahashi T, Ogawa K, Sawada S, et al. A case of refractory tuberculous meningitis markedly improved by intrathecal administration of isoniazid (INH). Rinsho Shinkeigaku. 2003;43(1–2):20–5.

    PubMed  Google Scholar 

  136. Prasad K, Singh MB. Corticosteroids for managing tuberculous meningitis. Cochrane Database of Systematic Reviews 2008, Issue 1. Art. No.: CD002244. doi:10.1002/14651858.CD002244.pub3.

  137. Torok ME, Yen NT, Chau TT, et al. Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV) – associated tuberculous meningitis. Clin Infect Dis. 2011;52(11):1374–83.

    PubMed  Google Scholar 

  138. Brancusi F, Farrar J, Heemskerk D. Tuberculous meningitis in adults: a review of a decade of developments focusing on prognostic factors for outcome. Future Microbiol. 2012;7(9):1101–16.

    PubMed  CAS  Google Scholar 

  139. Tan EK, Chee MW, Chan LL, Lee YL. Culture positive tuberculous meningitis: clinical indicators of poor prognosis. Clin Neurol Neurosurg. 1999;101(3):157–60.

    PubMed  CAS  Google Scholar 

  140. Rajshekhar V. Management of hydrocephalus in patients with tuberculous meningitis. Neurol India. 2009;57(4):368–74.

    PubMed  Google Scholar 

  141. Torok ME, Nguyen DB, Tran TH, et al. Dexamethasone and long-term outcome of tuberculous meningitis in Vietnamese adults and adolescents. PLoS One. 2011;6(12):e27821.

    PubMed  CAS  Google Scholar 

  142. Mamelak AN, Obana WG, Flaherty JF, Rosenblum ML. Nocardial brain abscess: treatment strategies and factors influencing outcome. Neurosurgery. 1994;35(4):622–31.

    PubMed  CAS  Google Scholar 

  143. Lee GY, Daniel RT, Brophy BP, Reilly PL. Surgical treatment of nocardial brain abscesses. Neurosurgery. 2002;51(3):668–71. discussion 671–2.

    PubMed  Google Scholar 

  144. Beaman BL, Beaman L. Nocardia species: host-parasite relationships. Clin Microbiol Rev. 1994;7(2):213–64.

    PubMed  CAS  Google Scholar 

  145. Barnicoat MJ, Wierzbicki AS, Norman PM. Cerebral nocardiosis in immunosuppressed patients: five cases. Q J Med. 1989;72(268):689–98.

    PubMed  CAS  Google Scholar 

  146. Uttamchandani RB, Daikos GL, Reyes RR, et al. Nocardiosis in 30 patients with advanced human immunodeficiency virus infection: clinical features and outcome. Clin Infect Dis. 1994;18(3):348–53.

    PubMed  CAS  Google Scholar 

  147. Lerner PI. Nocardiosis. Clin Infect Dis. 1996;22(6):891–903. quiz 904–5.

    PubMed  CAS  Google Scholar 

  148. Torres OH, Domingo P, Pericas R, et al. Infection caused by Nocardia farcinica: case report and review. Eur J Clin Microbiol Infect Dis. 2000;19(3):205–12.

    PubMed  CAS  Google Scholar 

  149. Cianfoni A, Calandrelli R, De Bonis P, et al. Nocardia brain abscess mimicking high-grade necrotic tumor on perfusion MRI. J Clin Neurosci. 2010;17(8):1080–2.

    PubMed  Google Scholar 

  150. Hall WA, Martinez AJ, Dummer JS, Lunsford LD. Nocardial brain abscess: diagnostic and therapeutic use of stereotactic aspiration. Surg Neurol. 1987;28(2):114–8.

    PubMed  CAS  Google Scholar 

  151. Wallace Jr RJ, Steele LC, Sumter G, Smith JM. Antimicrobial susceptibility patterns of Nocardia asteroides. Antimicrob Agents Chemother. 1988;32(12):1776–9.

    PubMed  CAS  Google Scholar 

  152. Kilincer C, Hamamcioglu MK, Simsek O, et al. Nocardial brain abscess: review of clinical management. J Clin Neurosci. 2006;13(4):481–5.

    PubMed  Google Scholar 

  153. Geiseler PJ, Andersen BR. Results of therapy in systemic nocardiosis. Am J Med Sci. 1979;278(3):188–94.

    PubMed  CAS  Google Scholar 

  154. Smego Jr RA, Moeller MB, Gallis HA. Trimethoprim-sulfamethoxazole therapy for Nocardia infections. Arch Intern Med. 1983;143(4):711–8.

    PubMed  Google Scholar 

  155. Obana WG, Rosenblum ML. Surgery for intracranial infections. In: Post KD, Friedman ED, McCormick P, editors. Postoperative complications in intracranial neurosurgery. New York: Thieme; 1993. p. 146–56.

    Google Scholar 

  156. US Department of Health and Human Services. Sexually transmitted disease surveillance. Atlanta, Georgia: Centers for Disease Control and Prevention; 2008. p. 2009.

    Google Scholar 

  157. Ciesielski CA. Sexually transmitted diseases in men who have sex with men: an epidemiologic review. Curr Infect Dis Rep. 2003;5(2):145–52.

    PubMed  Google Scholar 

  158. Hook 3rd EW, Marra CM. Acquired syphilis in adults. N Engl J Med. 1992;326(16):1060–9.

    PubMed  Google Scholar 

  159. Tramont EC. Treponema pallidum (Syphilis). In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. Orlando, FL: Churchill Livingstone; 2005. p. 2768–84.

    Google Scholar 

  160. Simon RP. Neurosyphilis. Arch Neurol. 1985;42(6):606–13.

    PubMed  CAS  Google Scholar 

  161. Kent ME, Romanelli F. Reexamining syphilis: an update on epidemiology, clinical manifestations, and management. Ann Pharmacother. 2008;42(2):226–36.

    PubMed  CAS  Google Scholar 

  162. Ghanem KG. Review: Neurosyphilis: a historical perspective and review. CNS Neurosci Ther. 2010;16(5):e157–68.

    PubMed  Google Scholar 

  163. Asdaghi N, Muayqil T, Scozzafava J, et al. The re-emergence in Canada of meningovascular syphilis: 2 patients with headache and stroke. CMAJ. 2007;176(12):1699–700.

    PubMed  Google Scholar 

  164. Merritt HH. The early clinical and laboratory manifestations of syphilis of the central nervous system. New Engl J Med. 1940;223:446–50.

    Google Scholar 

  165. Gurses C, Bilgic B, Topçular B, et al. Clinical and magnetic resonance imaging findings of HIV-negative patients with neurosyphilis. J Neurol. 2007;254(3):368–74.

    PubMed  Google Scholar 

  166. Harris DE, Enterline DS, Tien RD. Neurosyphilis in patients with AIDS. Neuroimaging Clin N Am. 1997;7(2):215–21.

    PubMed  CAS  Google Scholar 

  167. • Chahine LM, Khoriaty RN, Tomford WJ, Hussain MS. The changing face of neurosyphilis. Int J Stroke. 2011;6(2):136–43. In this article, an updated view on neurosyphilis in the era of AIDS and HIV is provided, outlining the outdated prior presentations and featuring the new presentations of neurosyphilis.

  168. Gaa J, Weidauer S, Sitzer M, et al. Cerebral vasculitis due to Treponema pallidum infection: MRI and MRA findings. Eur Radiol. 2004;14(4):746–7.

    PubMed  Google Scholar 

  169. Flint AC, Liberato BB, Anziska Y, et al. Meningovascular syphilis as a cause of basilar artery stenosis. Neurology. 2005;64(2):391–2.

    PubMed  CAS  Google Scholar 

  170. Vatz KA, Scheibel RL, Keiffer SA, Ansari KA. Neurosyphilis and diffuse cerebral angiopathy: a case report. Neurology. 1974;24(5):472–6.

    PubMed  CAS  Google Scholar 

  171. Holmes MD, Brant-Zawadzki MM, Simon RP. Clinical features of meningovascular syphilis. Neurology. 1984;34(4):553–6.

    PubMed  CAS  Google Scholar 

  172. Szilak I, Marty F, Helft J, Soeiro R. Neurosyphilis presenting as herpes simplex encephalitis. Clin Infect Dis. 2001;32(7):1108–9.

    PubMed  CAS  Google Scholar 

  173. Romberg EH. Pupillary disturbances in tabes. Z Gesamte Neurol Psy. 1939;165:369–72.

    Google Scholar 

  174. Musher DM, Hamill RJ, Baughn RE. Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment. Ann Intern Med. 1990;113(11):872–81.

    PubMed  CAS  Google Scholar 

  175. Ghanem KG, Moore RD, Rompalo AM, et al. Neurosyphilis in a clinical cohort of HIV-1-infected patients. AIDS. 2008;22(10):1145–51.

    PubMed  Google Scholar 

  176. Marra CM, Maxwell CL, Smith SL, et al. Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features. J Infect Dis. 2004;189(3):369–76.

    PubMed  Google Scholar 

  177. Walter T, Lebouche B, Miailhes P, et al. Symptomatic relapse of neurologic syphilis after benzathine penicillin G therapy for primary or secondary syphilis in HIV-infected patients. Clin Infect Dis. 2006;43(6):787–90.

    PubMed  CAS  Google Scholar 

  178. Bordon J, Martinez-Vazquez C, Alvarez M, et al. Neurosyphilis in HIV-infected patients. Eur J Clin Microbiol Infect Dis. 1995;14(10):864–9.

    PubMed  CAS  Google Scholar 

  179. Berger JR. Neurosyphilis in human immunodeficiency virus type 1-seropositive individuals. A prospective study. Arch Neurol. 1991;48(7):700–2.

    PubMed  CAS  Google Scholar 

  180. Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines. MMWR Recomm Rep. 2006;55(RR-11):1–94.

    PubMed  Google Scholar 

  181. Centers for Disease Control and Prevention (CDC). Symptomatic early neurosyphilis among HIV-positive men who have sex with men – four cities, United States, January 2002-June 2004. MMWR Morb Mortal Wkly Rep. 2007;56(25):625–8.

    Google Scholar 

  182. Golden MR, Marra CM, Holmes KK. Update on syphilis: resurgence of an old problem. JAMA. 2003;290(11):1510–4.

    PubMed  CAS  Google Scholar 

  183. Smith G, Holman RP. The prozone phenomenon with syphilis and HIV-1 co-infection. South Med J. 2004;97(4):379–82.

    PubMed  Google Scholar 

  184. Davis LE, Schmitt JW. Clinical significance of cerebrospinal fluid tests for neurosyphilis. Ann Neurol. 1989;25(1):50–5.

    PubMed  CAS  Google Scholar 

  185. Marshall DW, Brey RL, Cahill WT, et al. Spectrum of cerebrospinal fluid findings in various stages of human immunodeficiency virus infection. Arch Neurol. 1988;45(9):954–8.

    PubMed  CAS  Google Scholar 

  186. Marra CM, Maxwell CL, Collier AC, et al. Interpreting cerebrospinal fluid pleocytosis in HIV in the era of potent antiretroviral therapy. BMC Infect Dis. 2007;7:37.

    PubMed  Google Scholar 

  187. Bartt R. Listeria and atypical presentations of Listeria in the central nervous system. Semin Neurol. 2000;20(3):361–73.

    PubMed  CAS  Google Scholar 

  188. Southwick FS, Purich DL. Intracellular pathogenesis of listeriosis. N Engl J Med. 1996;334(12):770–6.

    PubMed  CAS  Google Scholar 

  189. Embil JA, Ewan EP, MacDonald SW. Surveillance of Listeria monocytogenes in human and environmental specimens in Nova Scotia, 1974 to 1981. Clin Invest Med. 1984;7(4):325–7.

    PubMed  CAS  Google Scholar 

  190. Armstrong D. Listeria monocytogenes. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and practice of infectious diseases. New York: Churchill Livingstone; 1995. p. 1880–5.

    Google Scholar 

  191. Disson O, Lecuit M. Targeting of the central nervous system by Listeria monocytogenes. Virulence. 2012;3(2):213–21.

    PubMed  Google Scholar 

  192. McLauchlin J. Human listeriosis in Britain, 1967–85, a summary of 722 cases. 2. Listeriosis in non-pregnant individuals, a changing pattern of infection and seasonal incidence. Epidemiol Infect. 1990;104(2):191–201.

    PubMed  CAS  Google Scholar 

  193. Mylonakis E, Hohmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes. 33 years’ experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore). 1998;77(5):313–36.

    CAS  Google Scholar 

  194. Schuchat A, Robinson K, Wenger JD, et al. Bacterial meningitis in the United States in 1995. Active Surveillance Team. N Engl J Med. 1997;337(14):970–6.

    PubMed  CAS  Google Scholar 

  195. Skogberg K, Syrjanen J, Jahkola M, et al. Clinical presentation and outcome of listeriosis in patients with and without immunosuppressive therapy. Clin Infect Dis. 1992;14(4):815–21.

    PubMed  CAS  Google Scholar 

  196. Watson GW, Fuller TJ, Elms J, Kluge RM. Listeria cerebritis: relapse of infection in renal transplant patients. Arch Intern Med. 1978;138(1):83–7.

    PubMed  CAS  Google Scholar 

  197. Grotta J, Nelson W, Matocha J. Listeria encephalitis. Arch Neurol. 1981;38(3):200.

    PubMed  CAS  Google Scholar 

  198. Harris JO, Marquez J, Swerdloff MA, Magana IA. Listeria brain abscess in the acquired immunodeficiency syndrome. Arch Neurol. 1989;46(3):250.

    PubMed  CAS  Google Scholar 

  199. Dee RR, Lorber B. Brain abscess due to Listeria monocytogenes: case report and literature review. Rev Infect Dis. 1986;8(6):968–77.

    PubMed  CAS  Google Scholar 

  200. Chu JY, Montanera W, Willinsky RA. Listeria spinal cord abscess – clinical and MRI findings. Can J Neurol Sci. 1996;23(3):220–3.

    PubMed  CAS  Google Scholar 

  201. Armstrong RW, Fung PC. Brainstem encephalitis (rhombencephalitis) due to Listeria monocytogenes: case report and review. Clin Infect Dis. 1993;16(5):689–702.

    PubMed  CAS  Google Scholar 

  202. Heck EF. Listeria monocytogenes. In: Vinken PJ, Bruyn GW, Klawans HL, editors. Handbook of clinical neurology. Amsterdam: Elsevier Scientific; 1978. p. 77–95.

    Google Scholar 

  203. Uldry PA, Kuntzer T, Bogousslavsky J, et al. Early symptoms and outcome of Listeria monocytogenes rhombencephalitis: 14 adult cases. J Neurol. 1993;240(4):235–42.

    PubMed  CAS  Google Scholar 

  204. Salgado MJ, Damani NN, Llewellyn CG, et al. Magnetic resonance imaging of abscesses of the brain stem and cerebellum complicating Listeria monocytogenes rhombencephalitis. Can Assoc Radiol J. 1996;47(6):431–3.

    PubMed  CAS  Google Scholar 

  205. Lavetter A, Leedom JM, Mathies Jr AW, Ivler D, et al. Meningitis due to Listeria monocytogenes. A review of 25 cases. N Engl J Med. 1971;285(11):598–603.

    PubMed  CAS  Google Scholar 

  206. Quagliarello VJ, Scheld WM. Treatment of bacterial meningitis. N Engl J Med. 1997;336(10):708–16.

    PubMed  CAS  Google Scholar 

  207. Rapp MF, Pershadsingh HA, Long Jr JW, Pickens JM. Ampicillin-resistant Listeria monocytogenes meningitis in a previously healthy 14-year-old athlete. Arch Neurol. 1984;41(12):1304.

    PubMed  CAS  Google Scholar 

  208. Levitz RE, Quintiliani R. Trimethoprim-sulfamethoxazole for bacterial meningitis. Ann Intern Med. 1984;100(6):881–90.

    PubMed  CAS  Google Scholar 

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Busl, K.M., Bleck, T.P. Bacterial Infections of the Central Nervous System. Curr Infect Dis Rep 15, 612–630 (2013). https://doi.org/10.1007/s11908-013-0384-7

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