Abstract
Background
Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs.
Conclusion
We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.
Similar content being viewed by others
References
Kralovics R, Passamonti F, Buser AS et al (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352:1779–1790. doi:10.1056/NEJMoa051113
Kumar S, Sarr MG, Kamath PS (2001) Mesenteric vein thrombosis. N Engl J Med 345:1683–1688. doi:10.1056/NEJMra010076
Baxter EJ, Scott EM, Campbell PJ et al (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365:1054–1061
Ihle JN, Gilliland DG (2007) JAK2: normal function and role in haematopoietic disorders. Curr Opin Gene Dev 17:8–14
Vannuchi AM, Antonioli E, Guglielmelli P et al (2007) Clinical profile of homozygous JAK2 V617F mutation in patients with polycythemia vera or essential thrombocythemia. Blood 110:840–846
Xu X, Zhang Q, Luo J (2007) JAK2 V617F: prevalence in a large Chinese hospital population. Blood 109:339–342. doi:10.1182/blood-2006-03-009472
Patel RK, Lea NC, Heneghan MA et al (2006) Prevalence of the activating JAK2 tyrosine kinase mutation V617F mutation in the Budd-Chiari syndrome. Gastroenterology 130:2031–2038. doi:10.1053/j.gastro.2006.04.008
De Stefano V, Fiorini A, Rossi E et al (2007) Incidence of the JAK2 V617F mutation among patients with splanchnic or cerebral venous thrombosis and without overt chronic myeloproliferative disorders. J Thromb Haemost 5:708–714. doi:10.1111/j.1538-7836.2007.02424.x
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bourke, M.G., Martin, S.T., O’Dwyer, M. et al. Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder. Ir J Med Sci 181, 285–287 (2012). https://doi.org/10.1007/s11845-009-0331-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11845-009-0331-7