Résumé
Des données cliniques et des témoignages de patients qui indiquent une efficacité du baclofène dans le traitement de l’alcoolisme se sont multipliés au cours de ces deux dernières années, mais beaucoup de prescripteurs sont toujours très réticents à l’utiliser. Pourtant, l’alcoolisme est une maladie mortelle pour laquelle n’existe aucun traitement véritablement efficace, en dehors du baclofène. Dans cet article, l’auteur rapporte son expérience de prescripteur de baclofène, avec une analyse des obstacles potentiels susceptibles de limiter son efficacité. Une approche des mécanismes biologiques par lesquels pourrait agir le baclofène est aussi proposée.
Abstract
Clinical data and patients’ accounts have provided accumulating evidence supporting the efficacy of baclofen in the treatment of alcoholism. However, alcohologists remain reluctant to prescribe baclofen. It should be remembered that alcoholism is a lethal illness for which no efficacious treatment exists, except baclofen. The author of the present paper relates his experience with the prescription of baclofen, and analyses the potential obstacles that may limit its efficacy. A biological approach of the mechanisms by which baclofen may act is also proposed.
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de Beaurepaire, R. Traitement de l’alcoolisme par le baclofène. Psychiatr Sci Hum Neurosci 9, 1–6 (2011). https://doi.org/10.1007/s11836-010-0159-2
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DOI: https://doi.org/10.1007/s11836-010-0159-2