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Biased immunoglobulin genes rearrangement in mantle cell lymphoma: Hints to identify the normal B-cell counterpart

  • Published:
Clinical Oncology and Cancer Research

Abstract

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, originating from naïve B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain (IgH) genes rearrangement for their importance in suggesting the MCL normal counterpart B-cell. Some new data suggesting an antigen selection process were also presented in this review.

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Authors and Affiliations

  1. Laboratory of Experimental Oncology, Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland

    Hui-lai Zhang, Francesco Bertoni & Franco Cavalli

  2. Department of Lymphoma, Tianjin Medical University Cancer Hospital and Institute, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China

    Hui-lai Zhang, Hua-qing Wang & Xi-shan Hao

  3. Division of Hematology, Department of Clinical and Experimental Medicine & Centro Interdisciplinare di Biotecnologie per la Ricerca Medica Applicata, “Amedeo Avogadro” University of Eastern Piedmont, Novara, Italy

    Daniela Capello

  4. Department of Pathology, State Hospital, St.Gallen, Switzerland

    Sergio B. Cogliatti

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  1. Hui-lai Zhang
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  2. Hua-qing Wang
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  6. Francesco Bertoni
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Correspondence to Hua-qing Wang.

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Zhang, Hl., Wang, Hq., Hao, Xs. et al. Biased immunoglobulin genes rearrangement in mantle cell lymphoma: Hints to identify the normal B-cell counterpart. Clin. Oncol. Cancer Res. 8, 65–70 (2011). https://doi.org/10.1007/s11805-011-0561-0

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  • DOI: https://doi.org/10.1007/s11805-011-0561-0

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